A5047396648- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Dental materials and restorations
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Silk-based biomaterials and applications
- Additive Manufacturing and 3D Printing Technologies
- Advanced Sensor and Energy Harvesting Materials
- Graphene and Nanomaterials Applications
- Laser-Ablation Synthesis of Nanoparticles
- Biopolymer Synthesis and Applications
- Medical and Biological Ozone Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Mesenchymal stem cell research
- Liver physiology and pathology
- Cellular Mechanics and Interactions
- Advanced Nanomaterials in Catalysis
- Bone and Dental Protein Studies
- Bone health and osteoporosis research
- Orthopaedic implants and arthroplasty
- Orthodontics and Dentofacial Orthopedics
- Proteoglycans and glycosaminoglycans research
University of Manchester
2015-2025
Henry Royce Institute
2022-2025
Smith College
2016
University of Memphis
2016
Texas A&M University
2016
John Wiley & Sons (United States)
2016
Syracuse University
2016
University of Patras
2015
Imperial College London
2005-2014
NIHR Imperial Biomedical Research Centre
2006-2014
Abstract Nature has evolved mechanisms to create a diversity of specialized materials through nanoscale organization. Inspired by nature, hybrid are designed with highly tailorable properties, which achieved careful control their interactions. These novel materials, based on silica‐gelatin system, have the potential serve as platform technology for human tissue regeneration. Covalent interactions between inorganic and organic constituents essential enable precise mechanical dissolution...
Clinical protocols utilize bone marrow to seed synthetic and decellularized allogeneic grafts for enhancement of scaffold remodeling fusion. Marrow-derived cytokines induce host neovascularization at the graft surface, but hypoxic conditions cause cell death core. Addition cellular components that generate an extensive primitive plexus-like vascular network would perfuse entire upon anastomosis could potentially yield significantly higher-quality grafts. We used a mouse model develop...
Nanocomposite scaffolds of bioactive glass foams containing tailor made rare earth oxide (i.e. nanoceria) additives were demonstrated to enhance the production collagen by HMSCs (Human Mesenchymal Stem Cells) compared without nanoceria. The addition osteogenic supplements was not required for this occur. Two different preparations nanoceria successfully incorporated in 3-D foam and with nanoparticles had individual particle sizes 3–5 nm while agglomerate size varied from 5–15 nm. Preliminary...
Abstract Spherical monodispersed bioactive particles are potential candidates for nanocomposite synthesis or as injectable that could be internalized by cells the local sustained delivery of inorganic therapeutic ions ( e.g., calcium strontium). Particles also likely to released from porous glass and sol–gel hybrid scaffolds they degrade; thus, it is vital investigate their interaction with cells. (mono‐SMBG), diameters 215 ± 20 nm synthesized using a modified Stöber process. Confocal...
Oxygen tension is a known regulator of mesenchymal stem cell (MSC) plasticity, differentiation, proliferation, and recruitment to sites injury. Materials capable affecting the MSC oxygen-sensing pathway, independently environmental oxygen pressure, are therefore immense interest tissue engineering (TE) regenerative medicine community. In this study, we describe evaluation effect hypoxia inducible factor (HIF)-stabilizing bioactive glasses (BGs) on human MSCs. The dissolution products from...
Triple-negative breast cancers are extremely aggressive with limited treatment options because of the reduced response cancerous cells to hormonal therapy. Here, monodispersed zinc-containing mesoporous silica nanoparticles (MSNPs-Zn) were produced as a tuneable biodegradable platform for delivery therapeutic zinc ions into cells. We demonstrate that internalized by cells, and dose window was identified in which MSNPs-Zn toxic cancer but not healthy epithelial (MCF-10a) or murine...
Abstract Here, we report on a rapid, noninvasive biophotonics system using Raman spectroscopy to detect real‐time biochemical changes in foetal osteoblasts (FOBs) following exposure 45S5 Bioglass® (BG)‐conditioned media. Bio‐Raman spectroscopy, combined with multivariate statistical analysis techniques (principal component and least squares analysis), was able noninvasively identify differences FOBs cultured for different time periods between exposed/or not BG‐conditioned Gene protein...
Abstract This study investigates the cellular response of fetal osteoblasts to bioactive resorbable composite films consisting a poly‐ D , L ‐lactide (PDLLA) matrix and glass 45S5 Bioglass® (BG) particles at three different concentrations (0% (PDLLA), 5% (P/BG5), 40% (P/BG40)). Using scanning electron microscopy (SEM) we observed that cells were less spread elongated on PDLLA P/BG5, whereas P/BG40 but with multiple protrusions spreading over BG particles. Vinculin immunostaining revealed...
Bone grafts are commonly used to regenerate bone in defect sites resulting from disease or trauma but there is clinical need for artificial materials that will be readily available and reduce pain recovery time the patient. Current graft include bioactive ceramics glasses, which too brittle defects experience cyclic load. The synthesis of a new nanocomposite material described has potential being tough off-the-shelf can have enough flexibility press-fit into place. poly(γ-glutamic...
It is well known that bone has excellent mechanical properties through its hierarchical structure and design of new materials should take inspiration from structure, especially those will be used as synthetic grafts. However it not yet been possible to mimic the complex structure. Here we present organic–inorganic hybrid scaffolds produced by a sol–gel foaming process with aim producing trabecular nanocomposite Poly(γ-glutamic acid) (γ-PGA) was chosen organic component because polypeptide...
Abstract Current materials used for bone regeneration are usually bioactive ceramics or glasses. Although they bond to bone, brittle. There is a need new that can combine bioactivity with toughness and controlled biodegradation. Sol‐gel hybrids have the potential do this through their nanoscale interpenetrating networks (IPN) of inorganic organic components. Poly(γ‐glutamic acid) (γ‐PGA) was introduced into sol‐gel process produce hybrid γ‐PGA silica. Calcium an important element but calcium...
Alginate fibrous materials have been applied as wound dressing to enhance healing due its nontoxic, biodegradable, and hemostatic nature. Conventional nonwoven fabrication tactics, however, showed weakness in inflammation, degradation stability mechanical properties. Herein, the wet-spun alginate fibers were prepared by a novel wheel spinning technique, then knitted into dressing. Benefiting from optimized wet parameters agglomeration of multimers, endowed with elevated performances...
Abstract In cell‐free scaffold tissue engineering (TE), an essential prerequisite is the design to promote cellular activities and formation. The success greatly dependent upon nature of including composition, topography, mechanical performance. Recent TE approaches use textile technologies create biomimetic functional scaffolds similar extracellular matrix (ECM). hierarchical architecture fiber yarn fabric allows precise size‐to‐scale design. Moreover, offer a high degree manufacturing...
Electrospinning allows the production of fibrous networks for tissue engineering, drug delivery and wound healing in healthcare. It enables constructs with large surface area a morphology that closely resembles extracellular matrix many tissues. A structure not only promotes cell attachment formation, but could also lead to very interesting mechanical properties. Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) is biodegradable polyester exhibits (>400%) elongation before...
The acute wound healing process requires a quick and short-stage vascular endothelial growth factor (VEGF) supply, especially, in the early-stage of injury. To date, research has rarely met demand for controlled VEGF release. Herein, novel wheel spinning technique was introduced to fabricate alginate (Alg)/silk fibroin (SF) composite fiber loading achieving controllable In turn, it demonstrated that parameter Alg/SF material morphological combination significantly influence release behavior...
Self-assembling peptide hydrogels (SAPH) are a popular biomaterial due to their biocompatibility with wide range of cell types, synthetic design, structural properties that provide more accurate 3D microenvironment, and potential for cell- and/or drug-delivery system. Mimicking solid tumors in vitro using is one method testing anti-cancer drug efficacy observing cancerous cell-ECM interactions within In this study, SAPH, PeptiGel®Alpha1, was used model the breast tumor microenvironment....