James W. Hamilton

ORCID: 0000-0002-9318-9548
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About
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Research Areas
  • Metabolism, Diabetes, and Cancer
  • Refrigeration and Air Conditioning Technologies
  • Parathyroid Disorders and Treatments
  • Media Studies and Communication
  • Pancreatic function and diabetes
  • Neuropeptides and Animal Physiology
  • Cellular transport and secretion
  • Social Media and Politics
  • Tribology and Lubrication Engineering
  • Genetic Syndromes and Imprinting
  • Psychotherapy Techniques and Applications
  • Mechanical Failure Analysis and Simulation
  • Acoustic Wave Phenomena Research
  • Vehicle Noise and Vibration Control
  • Southeast Asian Sociopolitical Studies
  • French Literature and Criticism
  • Hydraulic and Pneumatic Systems
  • Turbomachinery Performance and Optimization
  • Digital Games and Media
  • Cinema and Media Studies
  • Receptor Mechanisms and Signaling
  • Engineering Applied Research
  • Polyamine Metabolism and Applications
  • Mechanical Engineering and Vibrations Research
  • Bone health and treatments

Stanford University
2024

University of Georgia
2003-2021

University of Manchester
2019

Manchester University
2019

The Huntington Library, Art Museum, and Botanical Gardens
2019

SUNY Geneseo
1998-2018

Grady Memorial Hospital
2003-2018

University of California, San Diego
2008-2017

College of the Holy Cross
2013-2015

New Jersey City University
2014

1. Images of Large and Small Employers 2. The Economic Backdrop 3. Generating New Jobs 4. Wages: Bigger Means More 5. Who Benefits? 6. Total Package 7. Employer Size Unions 8. Political Resources 9. Influence 10. A Fuller Picture Notes References Index

10.2307/1060050 article EN Southern Economic Journal 1991-07-01

We have compared the amino acid and carbohydrate compositions, partial sequences, immunological crossreactivity, physical properties of secretory protein I parathyroid gland chromogranin A adrenal gland. This comparison indicates that these proteins are similar molecules. Because is present in granules containing parathormone cosecreted with hormone, because contained within chromaffin and, likewise, secreted catecholamines, observations raise possibility this class plays a general role...

10.1073/pnas.79.19.6056 article EN Proceedings of the National Academy of Sciences 1982-10-01

Calcemic fraction-A (CF-A) is a biologically active, hypercalcemic and bone resorptive peptide, which was detected in, isolated from, bovine parathyroid glands [Hamilton et al. (1971) Endocrinology 89, 1440-1447]. It has been further purified, its relationship to hormone clarified. The peptide present in fresh at concentration of about 3 mug/g (parathyroid hormone, 100 mug/g). contains 109 amino acids (hormone, 84), each equal or greater molar ratio than the hormone. Its molecular weight,...

10.1073/pnas.69.6.1521 article EN Proceedings of the National Academy of Sciences 1972-06-01

Abstract Bovine parathyroid gland slices were incubated in vitro buffers containing concentrations of calcium the range 0.5 mm to 2.0 and magnesium 0.2 1.7 either a 3H- or 14C-amino acid. After incubation, radioactive hormone was isolated from both tissue incubation medium by combination methods including gel filtration ion exchange chromatography. The isolation, localization, quantification present at various stages purification assisted adding samples, prior processing, small amounts...

10.1016/s0021-9258(18)62218-5 article EN cc-by Journal of Biological Chemistry 1971-05-01

Abstract Purified cathepsin B from porcine parathyroid glands was allowed to act upon radioactive bovine parathormone and proparathormone at various ratios of enzyme substrate for different times. The reaction products were isolated by ion exchange chromatography analyzed gel electrophoresis, amino acid composition, sequence analysis, bioassay. cleaved between residues 36 37 yielding a major carboxyl fragment appeared cleave the same locus. fragments degraded further removal small peptides...

10.1016/s0021-9258(17)30026-1 article EN cc-by Journal of Biological Chemistry 1979-06-01

Proparathyroid hormone (proPTH) and parathyroid (PTH) have been separated from rat gland extracts by a combination of methods including chemical fractionation, gel nitration ion exchange chromatography. The 2 peptides were shown to be similar bovine proPTH PTH, respectively, in their immunoreactivity, molecular weight size elution position during In radioisotope incorporation studies, they exhibited precursorproduct relationship comparable that observed for the prohormone hormone. After 13...

10.1210/endo-93-4-915 article EN Endocrinology 1973-10-01

This article summarizes and analyzes the dilemma of alternative media as it has been theorized in selected statements literatures mass communication. It locates source this theoretical assumptions about their resulting inability to escape seeming tradeoff between political effectiveness organizational/cultural massification. concludes by suggesting an way conceptualizing that instead leading efforts build mirror images mainstream organizations with all limitations, makes possible greater...

10.1177/0196859900024004002 article EN Journal of Communication Inquiry 2000-10-01

This article confronts a foundational problematic in Western-inflected scholarship on media and democracy by investigating the emergence, structure, operation of OhmyNews, Korean primarily online publication that hybridizes features both commercial ostensibly ‘alternative’ media. After an analysis informed social historical context politics, economics, society past 40 years, concludes OhmyNews is unique response to enabling conditions, its are inextricably part progressive nature. While...

10.1177/0163443706065028 article EN Media Culture & Society 2006-06-20

Chromogranin-A (CgA) is a ubiquitous protein which colocalizes in secretory granules of multiple endocrine tissues and cosecretes with peptide hormones from these tissues. Although the function CgA has remained unknown, there been recent interest its potential role as prohormone for smaller, biologically active peptides. We isolated characterized 26-kDa N-terminal fragment natural breakdown product bovine parathyroid storage. A similar, if not identical, secreted by glands. The elutes on...

10.1210/endo-129-6-3381 article EN Endocrinology 1991-12-01

We describe a simple cloning procedure for alpha 2u-globulin that requires neither enrichment of mRNA nor purification specific probe screening recombinant colonies. Total adult male liver poly(A)+RNA was used as template cloning, and the subsequent colonies were screened by comparing hybridization to radioactive cDNA probes prepared from hepatic female mRNA, respectively. Almost all selected "male-specific" clones later shown contain sequences. This cloned has been specifically hybridize...

10.1073/pnas.78.6.3478 article EN Proceedings of the National Academy of Sciences 1981-06-01

Bovine parathyroid gland slices were incubated in Krebs' buffer with [3H]leucine order to assess the biosynthesis and secretion of hormone (PTH). After incubation participate structures tissue extracted sodium deoxycholate yield primarily newly synthesized (radioactive) PTH extract preexisting granule residue. In pulse-chase experiments radioactive entered fraction at a time when total was declining, which indicates that some newly-synthesized packaged into these granules. The specific...

10.1210/endo-97-1-178 article EN Endocrinology 1975-07-01

Proparathyroid hormone (calcemic fraction-A) is a biosynthetic precursor of parathyroid in bovine glands. Limited amounts the isolated prohormone have been obtained for purpose initial structural studies. The results automated sequence analysis on two separate preparations indicate that N-terminal region consists Lys-Ser-Val-Lys-Lys-Arg followed by exactly corresponding to residues 1 34 hormone. Also observed was minor (about 12% total) which lysine absent. These data suggest more than one...

10.1073/pnas.71.3.653 article EN Proceedings of the National Academy of Sciences 1974-03-01

Dispersed porcine parathyroid cells were incubated with radioactive amino acid at 0.5 and 3.0 nw calcium, after which proteins of the medium analyzed. In addition to parathormone secretory protein-I, a carboxylterminal immunoactive fragment peak was detected that could be separated from intact hormone by differential precipitation 8–25% trichloroacetic acid. The components this analyzed for molecular size, peptides resulting tryptic digestion, sequences Edman degradation. results showed two...

10.1210/endo-107-1-164 article EN Endocrinology 1980-07-01

This paper explores details behind the phenomenal increase in global crude oil production over last century and a half implications if that trend should be reversed.I document key feature of growth has been exploitation new geographic areas rather than application better technology to existing sources, suggest end era could come soon.The economic dislocations historically followed temporary supply disruptions are reviewed, possible experience for what transition look like explored.

10.3386/w17759 preprint EN 2012-01-01
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