A5083705396- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Peripheral Artery Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Health and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cancer, Lipids, and Metabolism
- Coronary Interventions and Diagnostics
- Genetic Associations and Epidemiology
- Cardiovascular Effects of Exercise
- Pharmaceutical Economics and Policy
- Venous Thromboembolism Diagnosis and Management
Baylor College of Medicine
2016-2025
Michael E. DeBakey VA Medical Center
2016-2025
Houston Methodist
2014-2024
The University of Texas Health Science Center at Houston
2008-2023
Houston Methodist Sugar Land Hospital
2020-2023
German Center for Diabetes Research
2023
University Medical Center of the Johannes Gutenberg University Mainz
2023
German Cancer Research Center
2023
Helmholtz Zentrum München
2023
Center for Environmental Health
2023
Inflammation is linked to adverse outcomes in acute coronary syndromes. Myeloperoxidase, an abundant leukocyte enzyme, elevated culprit lesions that have fissured or ruptured patients with sudden death from cardiac causes. Numerous lines of evidence suggest mechanistic links between myeloperoxidase and both inflammation cardiovascular disease.
Background— We evaluated whether cardiac troponin T (cTnT) measured with a new highly sensitive assay was associated incident coronary heart disease (CHD), mortality, and hospitalization for failure (HF) in general population of participants the Atherosclerosis Risk Communities (ARIC) Study. Methods Results— Associations between increasing cTnT levels CHD, HF were Cox proportional hazards models adjusted traditional CHD risk factors, kidney function, high-sensitivity C-reactive protein,...
Abstract Aims The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model estimate 5- 10-year cardiovascular disease (CVD) in individuals aged over 70 years four geographical regions. Methods results Sex-specific competing risk-adjusted models for estimating CVD (CVD mortality, myocardial infarction, or stroke) were derived 65 without pre-existing atherosclerotic from Cohort Norway (28 503 individuals, 10 089 events). Models included age, smoking status,...
The study sought to determine the 99th percentile upper reference limit for high-sensitivity cardiac troponin T assay (hs-cTnT) in 3 large independent cohorts. presently recommended 14 ng/l cut point diagnosis of myocardial infarction using hs-cTnT was derived from small studies presumably healthy individuals, with relatively little phenotypic characterization. Data were included well-characterized population-based studies: Dallas Heart Study (DHS), Atherosclerosis Risk Communities (ARIC)...
<h3>Importance</h3> Secretory phospholipase A<sub>2</sub>(sPLA<sub>2</sub>) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA<sub>2</sub>inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect cardiovascular outcomes is unknown. <h3>Objective</h3> To determine the of sPLA<sub>2</sub>inhibition with outcomes. <h3>Design, Setting, Participants</h3> A double-blind, randomized, multicenter trial at 362 academic community...
Background— On the basis of studies with limited statistical power, lipoprotein(a) [Lp(a)] is not considered a risk factor for cardiovascular disease (CVD) in blacks. We evaluated associations between Lp(a) and incident CVD events blacks whites Atherosclerosis Risk Communities (ARIC) study. Methods Results— Plasma was measured (n=3467) (n=9851). Hazards ratios (HRs) (coronary heart ischemic strokes) were calculated. levels higher wider interindividual variation (median [interquartile range],...
P-selectin and intercellular adhesion molecule-1 (ICAM-1) participate in inflammatory processes by promoting of leukocytes to vascular wall endothelium. Their soluble levels have been associated with adverse cardiovascular events. To identify loci affecting (sP-selectin) ICAM-1 (sICAM-1), we performed a genome-wide association study sample 4115 9813 (sICAM-1) individuals European ancestry as part The Cohorts for Heart Aging Research Genome Epidemiology consortium. most significant SNP...
Obesity is a risk factor for various subtypes of cardiovascular disease (CVD), including coronary heart (CHD), failure (HF), and stroke. Nevertheless, there are limited comparisons the associations obesity with each these CVD subtypes, particularly regarding extent to which they unexplained by traditional mediators. We followed 13 730 participants in Atherosclerosis Risk Communities (ARIC) study who had body mass index ≥18.5 no at baseline (visit 1, 1987-1989). compared association higher...
Background: We assessed whether plasma troponin I measured by a high-sensitivity assay (hs-TnI) is associated with incident cardiovascular disease (CVD) and mortality in community-based sample without prior CVD. Methods: ARIC study (Atherosclerosis Risk Communities) participants aged 54 to 74 years baseline CVD were included this (n=8121). Cox proportional hazards models constructed determine associations between hs-TnI coronary heart (CHD; myocardial infarction fatal CHD), ischemic stroke,...
AimsCarotid intima–media thickness (CIMT) and plaque information can improve coronary heart disease (CHD) risk prediction when added to traditional factors (TRF). However, obtaining adequate images of all carotid artery segments (A-CIMT) may be difficult. Of A-CIMT, the common (CCA-IMT) is relatively more reliable easier measure. We evaluated whether CCA-IMT comparable A-CIMT TRF in improving CHD Atherosclerosis Risk Communities (ARIC) study.
Increased levels of plasma troponins and natriuretic peptides are associated with increased risk cardiovascular disease, but only limited information exists on these biomarkers stroke occurrence. In a prospective epidemiological study, we tested the hypothesis that high-sensitivity troponin T (TnT) N-terminal pro-B-type peptide (NT-proBNP) positively incidence stroke.The Atherosclerosis Risk in Communities (ARIC) Study measured TnT NT-proBNP 10 902 men or women initially free followed them...
Ultrasound measurements of arterial stiffness are associated with atherosclerosis risk factors, but limited data exist on their association incident cardiovascular events. We evaluated the carotid ultrasound-derived measures coronary heart disease (CHD) and ischemic stroke in Atherosclerosis Risk Communities (ARIC) study.Carotid strain compliance, distensibility indices, pressure-strain, Young elastic moduli were measured 10 407 individuals using ultrasound. Hazard ratios for CHD (myocardial...
High-sensitivity cardiac troponin T (hs-cTnT) is a biomarker of cardiovascular risk and could be approved in the United States for clinical use soon. However, data linking long-term temporal change hs-cTnT to outcomes are limited, particularly primary prevention settings.To examine association 6-year with incident coronary heart disease (CHD), failure (HF), all-cause mortality.This prospective observational cohort study, performed from January 1, 1990, December 31, 2011, included 8838...
Background— Obesity is a risk factor for heart failure (HF) but associated with lower N-terminal pro-brain natriuretic peptide (NT-proBNP) levels. It unclear whether the prognostic value and implications of NT-proBNP levels HF differ across body mass index (BMI) categories. Methods Results— We followed up 12 230 ARIC participants free prior at baseline (visit 2, 1990–1992) BMI ≥18.5 kg/m 2 . quantified compared relative absolute associations incident There were 1861 events during median 20.6...
Abstract Aims The benefit an individual can expect from preventive therapy varies based on risk-factor burden, competing risks, and treatment duration. We developed validated the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model for estimation of individual-level 10 years lifetime treatment-effects cholesterol lowering, blood pressure antithrombotic therapy, smoking cessation in apparently healthy people. Methods results Model development was conducted Multi-Ethnic Study...
The 2013 American College of Cardiology/American Heart Association (ACC/AHA) Cholesterol Management Guideline recommends moderate-intensity to high-intensity statin therapy in eligible patients.To examine adoption the ACC/AHA guideline US cardiology practices.Among 161 practices, trends use and nonstatin lipid-lowering (LLT) were analyzed before (September 1, 2012, November 2013) after (February 2014, April 2015) publication among 4 mutually exclusive risk groups within ACC Practice...