A5062401499- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Cancer Studies
- Breast Implant and Reconstruction
- Cardiovascular and exercise physiology
- Breast Cancer Treatment Studies
- Oral health in cancer treatment
- Effects of Radiation Exposure
- Angiogenesis and VEGF in Cancer
- Cardiovascular Effects of Exercise
- Trauma Management and Diagnosis
- Cardiovascular Disease and Adiposity
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- Lymphatic System and Diseases
- Biomarkers in Disease Mechanisms
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
- Sports Performance and Training
- Reconstructive Facial Surgery Techniques
- Cancer, Lipids, and Metabolism
- Muscle metabolism and nutrition
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Nitric Oxide and Endothelin Effects
Karolinska University Hospital
2016-2025
Karolinska Institutet
2015-2024
Klinikum rechts der Isar
2006-2024
Technical University of Munich
2004-2024
German Centre for Cardiovascular Research
2014-2023
Institute for Sports Medicine
1997-2018
St Göran's Children's Hospital
2018
German Sport University Cologne
2018
University of Siena
2017
Appalachian State University
2016
Abstract Aims The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model estimate 5- 10-year cardiovascular disease (CVD) in individuals aged over 70 years four geographical regions. Methods results Sex-specific competing risk-adjusted models for estimating CVD (CVD mortality, myocardial infarction, or stroke) were derived 65 without pre-existing atherosclerotic from Cohort Norway (28 503 individuals, 10 089 events). Models included age, smoking status,...
Coronary heart disease (CHD) is based on the development of atherosclerosis in coronary arteries. Shear stress-induced endothelial nitric oxide (NO) release not only contributes to local blood pressure control but also effectively helps retard atherosclerosis. Therefore, functionally relevant polymorphisms NO synthase (NOS-3) gene may contribute CHD. NOS-3 expression was analyzed cells isolated from umbilical cords genotyped for -786C/T single nucleotide polymorphism (SNP) human nos-3 gene....
Human obesity is associated with elevated leptin levels and a high risk of death from cardiovascular disease. In the present study, we investigated effects on vascular wound healing arterial lesion growth in mice.Wild-type mice placed an atherogenic, high-fat diet had (9-fold) compared their counterparts maintained normal chow, former demonstrated significantly enhanced neointimal thickening after carotid artery injury ferric chloride. The lesions forming response to strongly expressed...
The Omega-3 Index is defined as erythrocyte eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), represents an individual's status in these two marine omega-3 fatty acids. A target range of 8 to 11% has been suggested, because values below predispose cardiovascular events, especially sudden cardiac death, well suboptimal brain function, like prolonged reaction times or even depression. Compared with the general population, elite athletes have increased incidence death. not yet investigated...
Radiotherapy as a risk factor for free flap failure has been widely debated. The purpose of this study was to investigate vascular complications in surgery at center advocating preoperative radiotherapy. On the basis previous experimental studies, we also aimed temporal aspects both arteries and veins. Furthermore, effect tissue plasminogen activator (tPA), because irradiated microvascular recipient vessels are associated with impaired fibrinolysis.A retrospective review conducted 344...
Radiotherapy-induced cardiovascular disease is an emerging problem in a growing population of cancer survivors where traditional treatments, such as anti-platelet and lipid-lowering drugs, have limited benefits. The aim the study was to investigate vascular inflammatory patterns human survivors, replicate findings animal model, evaluate whether interleukin-1 (IL-1) inhibition could be potential treatment.Irradiated arterial biopsies were collected during microvascular autologous free tissue...
Introduction Up to one-fifth of breast cancer survivors will develop chronic cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard treatment. However, it mainly symptomatic and often ineffective in preventing BCRL progression. Lymphovenous anastomosis (LVA) vascularised lymph node transfer (VLNT) are microsurgical techniques that aim restore lymphatic drainage. This international randomised trial aims evaluate advantages interventions...
Autologous tissue transfer is often indicated to achieve improved quality during breast reconstruction after radiotherapy. The authors evaluated satisfaction with postmastectomy among irradiated patients. aim was compare deep inferior epigastric perforator (DIEP) and latissimus dorsi flaps regarding aesthetic outcome between patients plastic surgeons.Patients who underwent 24 consecutive DIEP 21 in combination prostheses were reviewed retrospectively. They received the Michigan Outcomes...
Radiotherapy (RT) is a risk factor for impaired outcomes after implant-based immediate breast reconstruction (IBR). Large studies including long-term follow-up are relatively scarce. The purpose of this analysis was to assess effects RT in IBR, distinguishing between implant removal because postoperative complications versus patient preference.This population-based cohort study included all patients with cancer who underwent IBR Stockholm 2005 and 2015. Data were collected through national...
Population-based studies have shown that exercise reduces cardiovascular morbidity and mortality. However, it is unknown whether these effects are solely a result of risk factor modification or directly affects the homeostasis vessel wall.We subjected 19-week-old apolipoprotein E (apoE)-knockout mice (apoE(-/-); n=25) to 6-week training program on motorized treadmill. The control group consisted 17 sedentary mice. After 3 weeks in program, underwent carotid artery injury with ferric...
Severe trauma to the extremities often includes a combination of fractures and soft tissue injuries. Several publications support that patient outcome is better when skeletal stabilization followed by early soft-tissue coverage. In an effort optimize treatment these patients, we established formalized collaboration in 2008 between Departments reconstructive plastic surgery orthopedics at Karolinska University Hospital.A retrospective review was conducted for all patients who had suffered...
BACKGROUND: Breast cancer-related lymphedema (BCRL) is a common complication lacking medical treatment. Lymfactin® an adenovirus type 5-based gene therapy and prolymphangiogenic growth factor vector that induces vascular endothelial C (VEGF-C) expression. Our aim was to evaluate the therapeutic effect of Lymfactin ® with vascularized lymph node transfer (VLNT). METHODS: This Phase II, double-blind, placebo-controlled, randomized multicenter study evaluated efficacy safety in combination...
Nearly half of all cancers are treated with radiotherapy alone or in combination other treatments, where damage to normal tissues is a limiting factor for the treatment. Radiotherapy-induced adverse health effects, mostly importance cancer patients long-term survival, may appear during long time after finishing and depend on patient's radiosensitivity. Currently, there no assay available that can reliably predict individual's response radiotherapy. We profiled two study sets from breast (n =...
Abstract Background Reconstructive surgery for mandibular osteoradionecrosis is increasing; however, evidence regarding the impact on health‐related quality of life lacking. The current exploratory study prospectively investigates whether resection with reconstruction associated changes in HRQoL parameters these patients. Methods Seventeen patients underwent microvascular between 2012 and 2015, 16 completed EORTC questionnaires QLQ‐C30 QLQ‐H&N35 1 month before year after surgery. Results...
As a consequence of the success present-day cancer treatment, radiotherapy-induced vascular disease is emerging. This caused by chronic inflammatory activation and likely orchestrated in part microRNAs. In irradiated versus nonirradiated conduit arteries from patients receiving microvascular free tissue transfer reconstructions, irradiation resulted down-regulation miR-29b up-regulation miR-146b. affected inflammation adverse wound healing through its targets pentraxin-3 dipeptidyl-peptidase...
Vascularized lymph node transfer (VLNT) is one option among other surgical treatments in the management of breast cancer-related lymphedema (BCRL). The cause concern regarding VLNT harvested from groin has been potential development secondary lower-extremity lymphedema. This study explored risks associated with donor-site morbidity following VLNT, or without concomitant reconstruction.
Abstract Radiotherapy (RT), a common cancer treatment, unintentionally harms surrounding tissues, including the skin, and hinders wound healing years after treatment. This study aims to understand mechanisms behind these late-onset adverse effects. We compare skin biopsies from previously irradiated (RT + ) non-irradiated − sites in breast survivors who underwent RT ago. Here we show that has compromised capacity fibroblast functions. Using ATAC-seq, discover altered chromatin landscapes...