A5078736105- Tracheal and airway disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Nitric Oxide and Endothelin Effects
- Esophageal and GI Pathology
- Head and Neck Cancer Studies
- Dysphagia Assessment and Management
- Salivary Gland Tumors Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Reconstructive Surgery and Microvascular Techniques
- Biomarkers in Disease Mechanisms
- Cardiac Arrest and Resuscitation
- Effects of Radiation Exposure
- Redox biology and oxidative stress
- Cleft Lip and Palate Research
- Vestibular and auditory disorders
- Congenital Heart Disease Studies
- Oral health in cancer treatment
- Angiogenesis and VEGF in Cancer
- Tumors and Oncological Cases
- Trauma Management and Diagnosis
- Circular RNAs in diseases
- Connexins and lens biology
- Polyomavirus and related diseases
- Surgical site infection prevention
- Lung Cancer Treatments and Mutations
Karolinska University Hospital
2007-2024
Karolinska Institutet
2005-2023
Nitric oxide (NO) is a universal mediator of biological effects in the brain. It has been implicated pathophysiological processes traumatic brain injury. Understanding its role vivo requires an understanding cellular sources and tissue compartments differentially regulated NO synthase (NOS) isoforms. This study was undertaken to investigate produced after experimental contusions rats, by analysis early expression three isoforms NOS, i.e., inducible, endothelial, neuronal isoforms.Focal were...
OBJECTIVE Nitric oxide is a universal mediator of biological effects in the brain, and it has been implicated pathophysiological processes traumatic brain injury. Experimental studies have indicated posttraumatic up-regulation three different isoforms nitric synthase (NOS) (i.e., inducible NOS [iNOS], endothelial NOS, neuronal NOS) after trauma. This study was undertaken to investigate cellular sources tissue compartments produced by human patients undergoing surgical treatment for...
Salivary gland malignancies are a very heterogeneous group of cancers, with histologically > 20 different subtypes, and prognosis varies greatly. Their etiology is unknown, however, few small studies show presence human papillomavirus (HPV) in some although the evidence for HPV having causal role weak. The aim this study was to investigate if plays development parotid salivary tumor subtypes.DNA extracted from 107 formalin fixed paraffin embedded tumors 10 corresponding metastases, tested 27...
Background: The impact of preoperative radiotherapy on microvascular reconstructive surgery outcome has been a subject debate. However, data are conflicting and often dependent local treatment protocols. We have studied the effects in unique, single-center setting where protocol change was undertaken from pre- to postoperative administration for microsurgical head neck reconstructions. Methods: A cohort study conducted 200 consecutive free flap cases, 100 were operated before after...
Optimum management of the N0 neck is unresolved in parotid salivary gland cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph metastasis and its´ clinical use increasing for head tumors. The object this study was to establish whether technique applicable distribution sentinel nodes tumors.Prosepective observational 30 patients with benign or low-grade T1-T2N0 malignant tumors planned surgical treatment. Distribution SN detected a preoperative ultrasound-guided...
Introduction Tracheomalacia (TM) often occurs in children with oesophageal atresia (OA), leading to recurrent respiratory symptoms and severe cases blue spells or ultimately arrest. In some patients, a secondary posterior tracheopexy may then be indicated. This surgery, as well morbidity, prevented by performing primary (PPT) concurrent OA correction. The aim of this trial is determine if PPT can decrease—or prevent—tracheal collapse newborns TM. Additionally, the aims whether potential...
Abstract Background Clinical studies have shown that radiotherapy increases the risk of cardiovascular disease at irradiated sites years after exposure. However, there is a lack biological explanations in humans. We therefore examined human blood vessels exposed to and studied C-reactive protein (CRP) pentraxin 3 (PTX3), new marker for adverse outcome dependent on TNF- alpha (TNFα) or interleukin-1beta (IL-1β) expression. Methods Pairs non-irradiated conduit arteries veins were harvested...
Background/Aim. Malignant tumors of the salivary glands are rare and heterogeneous, with more than 20 subtypes, classified mainly by histopathology. Their diagnosis is often challenging their etiology unknown. Here, possible association between human polyomaviruses (PyVs) one or gland tumor subtypes was examined. Materials Methods: Ninety-one primary tumors, including 12 eight corresponding metastases, were analyzed for presence DNA 10 different PyV species a bead-based multiplex assay using...
BackgroundRecurrent tracheoesophageal fistula (rTEF) is a well-known complication after surgery of EA, occurring in roughly 3–10% the patients. Recent studies have highlighted safety and efficacy endoscopic management recurrent TEF. The aim this study was to evaluate chemocauterization with trichloroacetic acid (TCA) rTEF congenital (cTEF).MethodsRetrospective chart review consecutive patients or TEF who underwent chemo-cauterization between 2018 2022 at tertiary center. Children diagnosed...
Supraglottoplasty (SGP) for severe laryngomalacia (LM) in children with medical comorbidities has been associated high risk of surgical failure and increased need postoperative pediatric intensive care unit (PICU) intervention, but evidence this is ambiguous. The objective was to evaluate outcome PICU-intervention following SGP LM comorbid patients.Retrospective observational study 116 patients treated between 2000 2021 at a tertial referral airway surgery center Karolinska University...
Clinical studies have shown that radiotherapy can induce vascular disease at the site of exposure but is usually not clinically evident until years after treatment. We studied irradiated human arteries and veins to better understand underlying biology in search future treatments. The aim was investigate whether contributed a sustained expression plasminogen activator inhibitor-1 (PAI-1) veins.Irradiated were harvested, together with unirradiated control vessels, from patients undergoing free...
OBJECTIVE Nitric oxide is a universal mediator of biological effects in the brain, and it has been implicated pathophysiological processes traumatic brain injury. Experimental studies have indicated posttraumatic up-regulation three different isoforms nitric synthase (NOS) (i.e., inducible NOS [iNOS], endothelial NOS, neuronal NOS) after trauma. This study was undertaken to investigate cellular sources tissue compartments produced by human patients undergoing surgical treatment for...
NS-04. A CASE REPORT OF GIANT CONGENITAL TERATOMA MANAGED THROUGH EX UTERO INTRAPARTUM TREATMENT PROCEDURE AND MULTIPLE STAGED SURGERIES Ulrika Sandvik1, Caroline Gahm2, Georgios Papatziamos2, Andreas Ekborn2, Erik Neovius3, Yinghua Li4, and Bengt Gustavsson1; Section for Neurosurgery, Department of Clinical Neuroscience. Karolinska University Hospital, Stockholm, Sweden; Otorhinolaryngology, Head Neck Surgery, Stockholm Craniofacial Center, Reconstructive Plastic Departmentof Neonatology,...