A5065110626- Intestinal Malrotation and Obstruction Disorders
- Appendicitis Diagnosis and Management
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Congenital Anomalies and Fetal Surgery
- Gastroesophageal reflux and treatments
- Hernia repair and management
- Intestinal and Peritoneal Adhesions
- Dysphagia Assessment and Management
- Congenital Diaphragmatic Hernia Studies
- Diverticular Disease and Complications
- Foreign Body Medical Cases
- Cardiac, Anesthesia and Surgical Outcomes
- Infant Nutrition and Health
- Bone health and osteoporosis research
- Testicular diseases and treatments
- Urological Disorders and Treatments
- Clinical Nutrition and Gastroenterology
- Hip and Femur Fractures
- Electrolyte and hormonal disorders
- Gallbladder and Bile Duct Disorders
- Meta-analysis and systematic reviews
- Nutritional Studies and Diet
Karolinska University Hospital
2016-2025
Karolinska Institutet
2014-2025
Southampton General Hospital
2020
University of Southampton
2015-2020
University College London
2015-2020
Great Ormond Street Hospital
2015-2020
Hospital for Sick Children
2015
Lund University
1996-2013
Akademiska Barnsjukhuset
2011
Boston Children's Hospital
2011
The aim of this study was to evaluate the feasibility and safety nonoperative treatment acute nonperforated appendicitis with antibiotics in children.A pilot randomized controlled trial performed comparing versus surgery for children. Patients imaging-confirmed who would normally have had emergency appendectomy were either or surgery. Follow-up 1 year.Fifty patients enrolled; 26 24 antibiotics. All children group histopathologically confirmed appendicitis, there no significant complications...
Objective: The aim of this study was to evaluate the safety and feasibility nonoperative treatment acute nonperforated appendicitis in children during 5 years follow-up. Methods: A 4-year follow-up a previous randomized controlled pilot trial, including 50 with appendicitis, performed. patients were initially antibiotics or appendectomy 1-year previously reported. Data extracted from computerized notes telephone interviews. primary outcome failure, defined as need for secondary intervention...
Introduction Many aspects of the management esophageal atresia (EA) and tracheoesophageal fistula (TEF) are controversial evidence for decision making is limited. Members European Reference Network Rare Inherited Congenital Anomalies (ERNICA) conducted a consensus conference on surgical EA/TEF based expert opinions referring to latest literature. Materials Methods Nineteen ERNICA representatives from nine countries participated in conference. The was prepared by item generation,...
Abstract Purpose The STAT trial is a multicenter randomized controlled in 12 centers worldwide aiming to determine the most effective operation for neonates with necrotizing enterocolitis (NEC) requiring intestinal resection: stoma formation (ST) or primary anastomosis (PA). Methods Infants having laparotomy NEC were intraoperatively PA ST if operating surgeon thought that both viable treatment options patient. outcome (duration of parenteral nutrition [PN]) was evaluated by Cox regression....
<h3>Background</h3> Appendectomy is considered the gold standard treatment for acute appendicitis. Recently need surgery has been challenged in both adults and children. In children there growing clinician, patient parental interest non-operative of appendicitis with antibiotics as opposed to surgery. To date no multicentre randomised controlled trials that are appropriately powered determine efficacy (antibiotics) compared (appendectomy) have performed. <h3>Methods</h3> Multicentre,...
To investigate the correlation between in-hospital surgical delay before appendectomy for suspected appendicitis and finding of perforated in children.All children undergoing acute at Karolinska University Hospital, Stockholm, Sweden from 2006 to 2013 were reviewed exposure delay. Primary endpoint was histopathologic appendicitis. The main explanatory variable delay, using surgery within 12 hours as reference. Secondary endpoints postoperative wound infection, intra-abdominal abscess,...
IntroductionAcute appendicitis in children is common and the optimal treatment modality still debated, even if recent data suggest that laparoscopic surgery may result shorter postoperative length of stay without an increased number complications. The aim study was to compare outcome open appendectomies during a transition period.Materials methodsThis retrospective cohort with prospectively collected data. All patients who underwent operation for suspected at Astrid Lindgren Children's...
Abstract Introduction Evidence supporting best practice for long-gap esophageal atresia is limited. The European Reference Network Rare Inherited Congenital Anomalies (ERNICA) organized a consensus conference on the management of patients with based expert opinion referring to latest literature aiming provide clear and uniform statements in this respect. Materials Methods Twenty-four ERNICA representatives from nine countries participated. was prepared by item generation, prioritization...
Cytomegalovirus (CMV) infection has been suggested to be of importance for the development and outcome biliary atresia (BA). However, most data are only available from single centre studies. We retrospectively collected on rates, outcomes, treatments ongoing CMV at time Kasai portoenterostomy (KPE) four different tertiary centres in Europe. The rate varied between 10-32% centres. positive patients were significantly older had higher levels several liver biochemistries KPE (p < 0.05 all...
Abstract Purpose This study aimed to explore parents’ experience of sham feeding their baby born with esophageal atresia at home, waiting for reconstructive surgery. Method Semi-structured interviews were conducted parents six children delayed reconstruction. The analyzed using qualitative content analysis. Results Parents experienced that feed reinforced the healthy abilities in baby. They had faith own ability as care child well see baby’s strength cope difficulties. expressed health...
Objective: Several surgical approaches are being used in the reconstruction of long-gap esophageal atresia. We investigated which methods Nordic countries and postoperative complications that occurred first year life. Methods: This study is a retrospective multicenter study, where medical records on children with atresia Gross type C or D born period from 1 January 2000 to May 2017 were reviewed. Results: Forty-four patients included this forty-three one D. Thirty-six statistical analysis....
Introduction Early differentiation between perforated and nonperforated acute appendicitis (AA) in children is of major benefit for the selection proper treatment. Based on pilot study data, we hypothesized that plasma sodium concentration at hospital admission a diagnostic marker perforation with AA. Materials Methods This was prospective accuracy study, including previously healthy children, 1 to 14 years age, Blood sampling included concentration, glucose, base excess, white blood cell...
The long-term incidence of acute appendicitis has been reported to be declining in Europe and North America. Recent reports, however, indicate stabilized or even increased rates. aim this study was investigate the present epidemiology appendicectomy a population-based cohort Swedish children.The National Patient Register queried for all children with and/or 1987-2013. Population-based rates were calculated. Rates age- sex-adjusted, analysed temporal regional trends.Some 56 774 identified,...
Abstract Background In 10–15% of children with esophageal atresia (EA) delayed reconstruction (DREA) is necessary due to long-gap EA and/or prematurity/low birth weight. They represent a patient subgroup high risk complications. We aimed evaluate postoperative morbidity and health-related quality life (HRQOL) in Swedish national cohort DREA. Methods Postoperative morbidity, age-specific generic HRQOL (PedsQL ™ 4.0) condition-specific (The EA-QOL questionnaires) DREA were compared who had...
Background: The support for treatment of uncomplicated appendicitis with non-operative management as opposed to surgery has been building in the literature. We conducted a randomized trial compare failure rates.Methods: pragmatic multicenter, parallel-group, unmasked, non-inferiority, completed at 11 children's hospitals across globe. used non-inferiority design margin 20%, and 1:1 allocation while stratifying by sex, institution duration symptoms (≥ 48 hours verses <48 hours). Patients were...
To study the impact of ongoing cytomegalovirus (CMV) infection at presentation biliary atresia (BA) on long-term outcome after Kasai procedure.Twenty-eight patients with BA born 1988-1997 were included and followed-up until 2007. Eleven (group A) had CMV compared to remaining 17 B). Median age procedure was 75 days in group A 70 B (p = 0.12).Including all patients, survival native liver 50% 36% 4 10 years follow-up respectively. At end follow-up, it 25% overall 68%. When comparing groups B,...