A5084983743- Neuroblastoma Research and Treatments
- Esophageal and GI Pathology
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Intestinal Malrotation and Obstruction Disorders
- Congenital Anomalies and Fetal Surgery
- Cancer, Hypoxia, and Metabolism
- Congenital gastrointestinal and neural anomalies
- Adrenal and Paraganglionic Tumors
- Hernia repair and management
- Gastroesophageal reflux and treatments
- Nanoplatforms for cancer theranostics
- Gastrointestinal disorders and treatments
- Dysphagia Assessment and Management
- Clinical Nutrition and Gastroenterology
- Advanced Fluorescence Microscopy Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Appendicitis Diagnosis and Management
- Glioma Diagnosis and Treatment
- Urological Disorders and Treatments
- Neonatal Respiratory Health Research
- Optical Imaging and Spectroscopy Techniques
- COVID-19 and healthcare impacts
- Testicular diseases and treatments
- Microtubule and mitosis dynamics
Great Ormond Street Hospital
2016-2025
University College London
2016-2025
Great Ormond Street Hospital for Children NHS Foundation Trust
2013-2024
University of California, Los Angeles
2024
Royal Marsden NHS Foundation Trust
2018
National Health Service
2012
Vanderbilt University
2011
In Brief Objective: We aimed to evaluate the effect of thoracoscopy in neonates on intraoperative arterial blood gases, compared with open surgery. Background: Congenital diaphragmatic hernia (CDH) and esophageal atresia tracheoesophageal fistula (EA/TEF) can be repaired thoracoscopically, but this may cause hypercapnia acidosis, which are potentially harmful. Methods: This was a pilot randomized controlled trial. The target number 20 (weight > 1.6 kg) were either (5 CDH, 5 EA/TEF) or...
The aim of this study was to investigate the factors associated with mortality in infants referred for surgical treatment advanced necrotizing enterocolitis (NEC).Retrospective review all confirmed (Bell stage II or III) NEC treated our unit during past 8 years (January 2002 December 2010). Data survivors and nonsurvivors were compared using Mann-Whitney test Fisher's exact are reported as median (range).Of 205 NEC, 35 (17%) medically managed; 170 (83%) had surgery; 66 (32%) died; received...
Introduction Many aspects of the management esophageal atresia (EA) and tracheoesophageal fistula (TEF) are controversial evidence for decision making is limited. Members European Reference Network Rare Inherited Congenital Anomalies (ERNICA) conducted a consensus conference on surgical EA/TEF based expert opinions referring to latest literature. Materials Methods Nineteen ERNICA representatives from nine countries participated in conference. The was prepared by item generation,...
Gastroschisis neonates have delayed time to full enteral feeds (ENT), possibly due bowel exposure amniotic fluid. We investigated whether delivery at <37weeks improves neonatal outcomes of gastroschisis and impact intra/extra-abdominal dilatation (IABD/EABD).A retrospective review (1992-2012) linked fetal/neonatal data 2 tertiary referral centers was performed. Primary were ENT length hospital stay (LOS). Data (median [range]) analyzed using parametric/non-parametric tests, positive/negative...
Abstract Introduction Evidence supporting best practice for long-gap esophageal atresia is limited. The European Reference Network Rare Inherited Congenital Anomalies (ERNICA) organized a consensus conference on the management of patients with based expert opinion referring to latest literature aiming provide clear and uniform statements in this respect. Materials Methods Twenty-four ERNICA representatives from nine countries participated. was prepared by item generation, prioritization...
Risk stratification scores for oesophageal atresia with tracheoesophageal fistula (OA-TOF) are useful to predict survival. Scores from single-centre series may lack external validity. We aimed model survival in OA-TOF and validate a new risk score using an international, multicentre database of patients. Retrospective data (2000-2022) 4 tertiary centres were used; multivariable logistic regression discharge was derived single centre data, then validated on the whole dataset bootstrapping. In...
Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children high-income (HICs). This study aimed test the hypothesis that COVID-19 pandemic had affected delivery healthcare services worldwide, exacerbated disparity paediatric outcomes between LMICs HICs.A multicentre, international, collaborative cohort study.91 hospitals centres 39 providing treatment patients March December...
Abstract Fluorescence-guided surgery is set to play a pivotal role in the intraoperative management of pediatric tumors. Shortwave infrared imaging (SWIR) has advantages over conventional near-infrared I (NIR-I) with reduced tissue scattering and autofluorescence. Here, two NIR-I dyes (IRDye800CW IR12), long tails emitting SWIR range, were conjugated clinical-grade anti-GD2 monoclonal antibody (dinutuximab-beta) compare for neuroblastoma surgery. A first-of-its-kind multispectral NIR-I/SWIR...
To create the first structured surgical report form for NBL with international consensus, to permit standardized documentation of all NBL-related procedures and their outcomes.NBL, most common extracranial solid malignant tumor in children, covers a wide spectrum tumors significant differences anatomical localization, organ or vessel involvement, biology. Complete resection primary is an important part treatment, but maybe hazardous, prone complications its role high-risk disease remains...
<b>Objectives</b> Improved survival in infants with esophageal atresia (EA) a birth weight < 1,500 g or major cardiac anomaly has been reported when compared the original Spitz classification proposed 1994. <b>Aim</b> We reviewed outcome data for born over last decade our institution to update previously statistics. <b>Materials and Methods</b> The records of all neonates (<i>n</i> = 200) diagnosis EA managed single between 2001 2011 were from study subsequent cohort same institution. Data...
<b>Aim of the Study</b> The aim this study was to report incidence and clinical outcomes recurrent necrotizing enterocolitis (NEC). <b>Methods</b> Review infants treated for episode(s) NEC at a tertiary Neonatal Surgical Intensive Care Unit over 8 years (January 2002 February 2011). Demographic, clinical, radiological, operative data were analyzed compared using Mann-Whitney or Fisher's exact tests. Data are reported as median (range). <b>Results</b> A total 212 consecutive referred surgical...
To determine whether fluoroscopic balloon dilation (FBD) is a safe and effective method of treating esophageal anastomotic stricture after surgical repair in an unselected patient population.With ethics committee approval, records for 103 consecutive patients who underwent FBD with our interventional radiology service (1999-2011) were reviewed retrospectively. Patients diagnostic contrast material-enhanced study prior to the first dilation. Dilations performed by using general anesthesia....