A5031040350- Neuroblastoma Research and Treatments
- Adrenal and Paraganglionic Tumors
- Congenital Diaphragmatic Hernia Studies
- Neurofibromatosis and Schwannoma Cases
- Tracheal and airway disorders
- Testicular diseases and treatments
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Myasthenia Gravis and Thymoma
- Appendicitis Diagnosis and Management
- Clinical Reasoning and Diagnostic Skills
- Renal cell carcinoma treatment
- Airway Management and Intubation Techniques
- Intestinal Malrotation and Obstruction Disorders
- Lung Cancer Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Aortic Disease and Treatment Approaches
- Soft tissue tumor case studies
- Male Breast Health Studies
- Cancer therapeutics and mechanisms
- Spinal Dysraphism and Malformations
- Esophageal and GI Pathology
- Trauma Management and Diagnosis
- Pituitary Gland Disorders and Treatments
Great North Children's Hospital
2017-2024
Newcastle University
2017-2024
University of Newcastle Australia
2023-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
Alder Hey Children's Hospital
2017-2021
University of Liverpool
2017-2021
Nottingham University Hospitals NHS Trust
2021
Queen's Medical Centre
2021
Liverpool Women's Hospital
2021
Royal Victoria Infirmary
2019
Circulating tumor cells (CTCs) serve as noninvasive biomarkers in many types of cancer. Our aim was to detect CTCs from patients with neuroblastoma for use predictive and pharmacodynamic biomarkers.We collected matched blood bone marrow samples 40 GD2+/CD45- disseminated (DTCs) using the Imagestream Imaging flow cytometer (ISx). In six cases, circulating free DNA (cfDNA) extracted plasma isolated CTC sample analyzed by high-density single-nucleotide polymorphism (SNP) arrays.CTCs were...
To create the first structured surgical report form for NBL with international consensus, to permit standardized documentation of all NBL-related procedures and their outcomes.NBL, most common extracranial solid malignant tumor in children, covers a wide spectrum tumors significant differences anatomical localization, organ or vessel involvement, biology. Complete resection primary is an important part treatment, but maybe hazardous, prone complications its role high-risk disease remains...
To define the factors influencing outcome of aortopexy as management tracheo-bronchomalacia.A retrospective, single-center, observational, cohort study.Surgical services in a tertiary care hospital.One hundred five children who underwent an for tracheo-bronchomalacia between 1990 and 2008.None.Comorbidity (categorized into three groups), surgical approach, location malacia were reviewed analyzed relation to mortality, need second intervention, complications, time extubation after surgery,...
Gynaecomastia is a benign condition which commonly seen in adolescent males. The aim of this study to assess the complications and cosmetic outcome surgical treatment management gynaecomastia.Thirty-nine males had subcutaneous mastectomy for gynaecomastia at Booth Hall Royal Manchester Children's Hospitals between 1995 - 2001 inclusive. A retrospective analysis was performed addition chart review, personal telephone interviews were conducted patients' satisfaction with results...
Abstract Background A major shift in treatment of appendicitis occurred early the SARS-CoV-2 pandemic with non-operative management used commonly outside research protocols and units limited previous experience. This study aims to compare real-world outcomes surgery versus uncomplicated children 1-year follow-up. Method prospective multicentre observational treated for at 74 hospitals UK Ireland from 1 April 31 July 2020 was performed. Propensity-score matched analysis conducted using age,...
Sacrococcygeal teratoma (SCT) is a rare paediatric germ cell tumour (1:40,000). Long-term data regarding urinary tract and bowel function after SCT resection limited to few studies. A UK Children's Cancer Leukaemia Group (CCLG) Surgeons multicentre study aimed critically analyse long-term functional outcomes in patients following of SCT.Nationwide surgical oncology centres using standardised collection form. All index cases newborn infants children <16 years with diagnosis during 2005-2015...
Background Ganglioneuroblastoma intermixed (GNBi) and ganglioneuroma (GN) are benign subtypes of neuroblastic tumors. Primary observation has become accepted management for some patients with surgical operative strategies evolving to be less aggressive. Objectives Our study examines in a UK cohort investigating natural history, biology clinical features GN ganglioneuroblastoma-intermixed those having or surgery. Methods Retrospective review histologically confirmed GNBi managed over 30 year...
ABSTRACT Background Ganglioneuroblastoma intermixed (GNBi) and ganglioneuroma (GN) represent benign variants of peripheral neuroblastic tumours. While historically surgical resection was recommended, watchful active observation has become the accepted management for a subset patients. Objectives To review clinical features, biology, natural history retrospective UK CCLG study cohort GN GNBi, compare outcomes patients treated with or observation. Methods Retrospective histologically confirmed...
Aim To provide a further insight into the usefulness of lung biopsy in children. Methods Lung biopsies children from January 2007 to December 2017 were reviewed (n=39). The histology results categorised as: definitive diagnosis, normal parenchyma, inconclusive. Results provided diagnosis 25 (64%) cases. A suspected was confirmed 16 (41%) and new found 9 (23%) Histology inconclusive 11 (28%) cases 3 (8%). Fifteen (38%) had treatment altered due result. Conclusion mostly associated with low...
As it originates from neural crest cells, Neuroblastoma (NBL) can arise anywhere along the sympathetic chain. However, its occurrence in urinary bladder (UB) is extremely rare. We present a case of an incidentally diagnosed pelvic NBL arising dome UB 7-month-old infant. The mass was treated with surgical excision only after being classified as very low risk group according to International Risk Group staging system. patient disease free 5 years follow-up. Although rare, we suggest that...
Abstract PURPOSE Preoperative evaluation of Image Defined Risk Factors (IDRFs) in neuroblastoma (NB) is crucial for determining suitability upfront resection or tumor biopsy. IDRFs do not all carry the same weighting predicting complexity and surgical risk. In this study we aimed to assess categorize a (Surgical Complexity Index, SCI) NB resection. METHODS A panel 15 surgeons was involved an electronic Delphi consensus survey identify score set shared items predictive and/or indicative...
BACKGROUND Preoperative evaluation of Image Defined Risk Factors (IDRFs) in neuroblastoma (NB) is crucial for determining suitability upfront resection or tumor biopsy. IDRFs are linked with a higher potential morbidity at operation and lessen the chance complete resection. The do not all carry same weight predicting complexity surgical risk. In this study we aimed to assess categorize degrees (Surgical Complexity Index, SCI) NB PROCEDURE A panel 15 surgeons was involved an electronic Delphi...