A5006649220- Ovarian cancer diagnosis and treatment
- Neuroblastoma Research and Treatments
- Testicular diseases and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Adrenal and Paraganglionic Tumors
- Appendicitis Diagnosis and Management
- Diverticular Disease and Complications
- Childhood Cancer Survivors' Quality of Life
- Management of metastatic bone disease
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Sympathectomy and Hyperhidrosis Treatments
- Delphi Technique in Research
- Pelvic and Acetabular Injuries
- Neurofibromatosis and Schwannoma Cases
- Colorectal Cancer Screening and Detection
- Reproductive Biology and Fertility
- Anorectal Disease Treatments and Outcomes
- Cancer and Skin Lesions
- Spinal Dysraphism and Malformations
- Sphingolipid Metabolism and Signaling
- Clinical practice guidelines implementation
- Surgical site infection prevention
Leeds Teaching Hospitals NHS Trust
2015-2025
NHS Greater Glasgow and Clyde
2025
Alder Hey Children's Hospital
2019-2024
University of Liverpool
2019-2024
University of Edinburgh
2016-2024
Royal Hospital for Children
2024
Royal Manchester Children's Hospital
2016-2022
Great Ormond Street Hospital
2020
University College London
2020
Manchester University NHS Foundation Trust
2019
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive malignancy with fewer than 100 paediatric cases reported. This report details boy who presented in young childhood skin lesion on his left buttock that clinically resembled sarcomatous lesion. Histopathological work-up including flow cytometry, immunophenotyping phenotypic correlation were consistent the diagnosis of BPDCN. The BPDCN radically altered this patient’s treatment pathway. case highlights importance...
Abstract Background Research studies to inform clinical practice and policy in children young people with appendicitis are hampered by inconsistent selection reporting of outcomes. The aim this study was develop a core outcome set for all uncomplicated acute people. Methods Systematic literature reviews, qualitative interviews parents patients treated appendicitis, Study-Specific Advisory Group informed long list Outcomes were then prioritized stakeholders based the UK (patients, parents,...
Abstract The phospholipid mediator sphingosine 1-phosphate (S1P) enhances motility and endocytosis of mature dendritic cells (DCs). We show that in vitro migration Swap-70−/− bone marrow-derived DCs (BMDCs) response to S1P S1P-induced upregulation are significantly reduced. S1P-stimulated movement BMDCs, specifically retraction their trailing edge, a collagen three-dimensional environment is impaired. These observations correlate with delayed entry into lymphatic vessels lymph nodes skin...
Abstract Aim No widely agreed consensus protocols exist for the management of benign ovarian tumors (BOT) in children. This presents a substantial risk suboptimal management. We aimed to generate multispecialty guidance standardize surgical and provide clear follow‐up protocol children with BOTs. Methods Prospective two‐round confidential e‐Delphi survey distributed among expert panel; concluded by two semistructured videoconferences. Main results Consensus was generated on these core...
Ovarian teratomas in prepubertal females are uncommon, but familial ones exceedingly rare. We report an ovarian teratoma 8-year-old girl, her mother, and maternal grandmother. The risk of a metachronous tumor subsequent complications (such as torsion) the contralateral ovary remain unclear. There is no clear guidance on follow-up management patient family members literature. have reviewed literature discuss challenges for pediatric surgeon arising from such cases.
Sacrococcygeal teratoma (SCT) is a rare paediatric germ cell tumour (1:40,000). Long-term data regarding urinary tract and bowel function after SCT resection limited to few studies. A UK Children's Cancer Leukaemia Group (CCLG) Surgeons multicentre study aimed critically analyse long-term functional outcomes in patients following of SCT.Nationwide surgical oncology centres using standardised collection form. All index cases newborn infants children <16 years with diagnosis during 2005-2015...
We describe the case of a previously healthy 12-year-old boy admitted to tertiary paediatric centre with clinical diagnosis Henoch-Schonlein purpura (HSP). Symptoms on admission included generalised rash, colicky abdominal pain, hypertension, proteinuria and fresh rectal bleeding. Abdominal pain distension worsened serial ultrasounds suggested bowel ischaemia. He underwent repeat laparotomy resection, slow improvement after second laparotomy. The severity systemic involvement...
The first national multispecialty survey that shows we don't.
Background Ganglioneuroblastoma intermixed (GNBi) and ganglioneuroma (GN) are benign subtypes of neuroblastic tumors. Primary observation has become accepted management for some patients with surgical operative strategies evolving to be less aggressive. Objectives Our study examines in a UK cohort investigating natural history, biology clinical features GN ganglioneuroblastoma-intermixed those having or surgery. Methods Retrospective review histologically confirmed GNBi managed over 30 year...