A5103257666- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Clinical Nutrition and Gastroenterology
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Intestinal Malrotation and Obstruction Disorders
- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Pediatric Hepatobiliary Diseases and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Congenital Heart Disease Studies
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Diabetes Management and Research
- Viral gastroenteritis research and epidemiology
- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Infant Development and Preterm Care
- Breastfeeding Practices and Influences
- Folate and B Vitamins Research
- Ovarian function and disorders
- Advanced MRI Techniques and Applications
- Cleft Lip and Palate Research
- Liver Disease and Transplantation
Leeds Teaching Hospitals NHS Trust
2025
University of Toronto
2015-2024
SickKids Foundation
2011-2024
Hospital for Sick Children
2015-2024
Hull Royal Infirmary
2024
University Hospital of Wales
2021
RELX Group (United States)
2019
Toronto Public Health
2015
Institute for Clinical Evaluative Sciences
2011-2013
Great Ormond Street Hospital
2010
PURPOSE: To determine whether absence of bowel wall perfusion at color Doppler ultrasonography (US) is indicative necrosis in neonates with necrotizing enterocolitis (NEC). MATERIALS AND METHODS: This study was approved by the research ethics board, and informed consent obtained. Sixty-two enrolled prospective underwent US wall. Neonates were divided into two groups. Group A included 30 control subjects gestational ages (GAs) ranging from 24 to 41 weeks. B 32 GAs 40 weeks who clinically...
Background : To examine whether SMOFlipid prevents progression of intestinal failure–associated liver disease (IFALD) in parenteral nutrition (PN)–dependent infants with early IFALD (conjugated bilirubin 17–50 µmol/L, 1‐3 mg/dL). Study Design Pilot multicenter blinded randomized controlled trial comparing Intralipid. Patients received the lipid for up to 12 weeks, unless they achieved full enteral tolerance sooner. The primary clinical outcome was serum conjugated bilirubin. Results...
OBJECTIVES. Hypoglycemia is a significant problem in neonates, and pattern of parietooccipital diffusion restriction on MRI scans has been reported. The purpose this study was to determine whether hypoglycemic injury, as indicated by the occipital lobes, correlated with visual evoked potentials long-term cortical dysfunction. METHODS. A cohort 45 neonates from 2000–2005 diffusion-weighted studies after hypoglycemia studied retrospectively. Perinatal history follow-up data were analyzed,...
Neonatal stroke is increasingly recognized, and risk factors have been identified. The placenta has implicated as a potential contributor to neonatal stroke; however, pathology not previously described. This case series systematically evaluates prenatal, maternal, describes placental in 12 cases of stroke.We reviewed the Canadian Pediatric Ischemic Stroke Registry from 1992 2006, which consists 186 patients. Twelve patients with symptomatic cerebral arterial ischemic or sinovenous thrombosis...
Background : Given the recent interest in role of ω‐6 lipids development intestinal failure–associated liver disease (IFALD), authors sought to examine parenteral a serum conjugated bilirubin >100 µmol/L (5.9 mg/dL; CB100) infants. Method Between 2003 and 2004, data were collected prospectively on infants undergoing an abdominal surgical procedure. Univariate logistic regression models for prediction CB100 by 1 year postoperatively developed. Predictors significant at 0.2 level univariate...
Recent reports show increases in rates of ankyloglossia and frenotomy British Columbia. We carried out a study to determine temporal trends regional variations Canada.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive malignancy with fewer than 100 paediatric cases reported. This report details boy who presented in young childhood skin lesion on his left buttock that clinically resembled sarcomatous lesion. Histopathological work-up including flow cytometry, immunophenotyping phenotypic correlation were consistent the diagnosis of BPDCN. The BPDCN radically altered this patient’s treatment pathway. case highlights importance...
Objectives We sought to test the assumption that measured concentrations of medication infusions are within pharmaceutical standards (±10% intended concentrations) and whether, at time infusion was mixed, professional background persons preparing or unit for which prepared were related observed variation. Design, Setting, Participants This prospective, observational study conducted in neonatal pediatric intensive care units a university-affiliated tertiary center. Morphine clinical use...
Congenital surfactant deficiency (CSD) is a newly identified neonatal lung disorder associated with variety of molecular defects affecting synthesis and secretion in alveolar type II cells. The authors present ultrastructural findings abnormal lamellar bodies biopsies from 4 infants CSD. All were term presenting shortly after birth severe respiratory failure that was unresponsive to conventional therapy all died within the first month life. Lung performed between 8 25 days age. Biochemical...
Background and Purpose— In neonates, the differentiation of stroke hypoxic ischemic encephalopathy (HIE) is important. Neuroimaging presents technical challenges in unstable resulting frequently delayed or missed diagnosis stroke. Differentiating clinical electroencephalographic (EEG) features would assist physicians timely diagnosis. We sought to determine, neonates with seizures, EEG that differentiate HIE. Methods— Retrospective cohort study comparing clinical, seizure, term HIE seizures...
A twofold increase in the prevalence of congenital heart defects (CHDs) has been reported since early 1970s with higher rates among children from low socioeconomic status (SES). This and observed SES gap are postulated to be reflective ascertainment, especially increased use ultrasound echography. The purpose this study was examine if trends over time CHD were same for high groups.Using child's health number as a unique identifier through record linkage, born Ontario between 1994 2007...