A5078934913- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Effects and risks of endocrine disrupting chemicals
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Maternal and Perinatal Health Interventions
- Per- and polyfluoroalkyl substances research
- Global Maternal and Child Health
- Influenza Virus Research Studies
- Toxic Organic Pollutants Impact
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Folate and B Vitamins Research
- Heavy Metal Exposure and Toxicity
- Pregnancy and Medication Impact
- Assisted Reproductive Technology and Twin Pregnancy
- Vitamin D Research Studies
- Metabolism and Genetic Disorders
- Water Treatment and Disinfection
- Infant Development and Preterm Care
- Breastfeeding Practices and Influences
- Obesity, Physical Activity, Diet
- Congenital Anomalies and Fetal Surgery
- Preterm Birth and Chorioamnionitis
Dalhousie University
2016-2025
Izaak Walton Killam Health Centre
2012-2024
University of Miami Health System
2022
Ottawa Hospital
2021
Ottawa Hospital Research Institute
2021
University of Ottawa
2006-2021
University of Toronto
1993-2021
SickKids Foundation
2021
3M (United States)
2021
Public Health Ontario
2021
Excess deaths have occurred among pregnant women during influenza pandemics, but the impact of nonpandemic years is unclear. We evaluated exposure seasons on rates hospital admissions and physician visits because respiratory illness women.We conducted a 13-year (1990-2002) population-based cohort study involving in Nova Scotia. compared office season each trimester pregnancy with year before non-influenza seasons. Poisson regression analyses were performed to estimate rate ratios 95%...
In Brief OBJECTIVE: To determine if the rates of pregnancy complications, preterm birth, small for gestational age, perinatal mortality, and serious neonatal morbidity are higher among mothers aged 35–39 years or 40 older, compared with 20–24 years. METHODS: We performed a population-based study all women in Nova Scotia, Canada, who delivered singleton fetus between 1988 2002 (N = 157,445). Family income 1995 was obtained through confidential linkage tax records (n 76,300). The primary...
Studies from several countries report increases in rates of gestational diabetes mellitus (GDM) over recent decades. Exposure to environmental chemicals could contribute this trend.To determine the associations between plasticisers and metals measured early pregnancy with impaired glucose tolerance (IGT) GDM a Canadian cohort.Women enrolled Maternal-Infant Research on Environmental Chemicals (MIREC) Study were included if they had singleton delivery did not have pre-existing diabetes. Eleven...
In Brief OBJECTIVE: To evaluate maternal and neonatal outcomes among women with hyperemesis during pregnancy. METHODS: A population-based retrospective cohort study was conducted singleton deliveries between 1988 2002. Hyperemetic pregnancies were defined as those requiring one or more antepartum admissions for before 24 weeks of gestation. Severity evaluated according to the number antenatal hospital (1 2 versus 3 more) weight gain pregnancy (< 7 kg [15.4 lb] ≥ kg). Maternal included...
In Brief OBJECTIVE: To identify risk factors for hyperemesis requiring hospital admission during pregnancy. METHODS: Data from a population-based cohort of all deliveries in Nova Scotia, Canada between 1988 and 2002 were obtained the Scotia Atlee Perinatal Database. Women with 1 or more antepartum admissions compared women no hyperemesis. Relative risks (RRs) 95% confidence intervals (CIs) estimated using logistic regression used to determine set independent RESULTS: The overall rate was...
To estimate the contribution of changes in maternal characteristics (namely, age, parity, prepregnancy weight, weight gain pregnancy, smoking status) and obstetric practice labor induction, epidural anesthesia, delivery by an obstetrician, midpelvic forceps delivery) to recent increases primary cesarean rates. We studied all deliveries Nova Scotia, Canada, between 1988 2000 after excluding women who had a previous (n = 127,564). Logistic regression was used study effect on The examined...
The Maternal-Infant Research on Environmental Chemicals (MIREC) Study was established to obtain Canadian biomonitoring data for pregnant women and their infants, examine potential adverse health effects of prenatal exposure priority environmental chemicals pregnancy infant health.Women were recruited during the first trimester from 10 sites across Canada followed through delivery. Questionnaires administered post-delivery collect information demographics, occupation, life style, medical...
<b>Background:</b> The health care system in Canada provides essential services to all women irrespective of socioeconomic status. Our objective was determine whether perinatal and infant outcomes varied by family income other factors this setting. <b>Methods:</b> We included 92 914 who delivered Nova Scotia between 1988 1995 following a singleton pregnancy. Family obtained for 76 440 these through confidential link tax records divided into 5 groups. Outcomes studied pregnancy complications,...
Studies report increases in rates of gestational diabetes mellitus (GDM) over recent decades. Environmental chemicals may increase the risk through impacts on glucose metabolism, mitochondrial dysfunction, and endocrine-disrupting mechanisms including effects pancreatic β-cell function adiponectin release. To determine associations between pesticides, perfluoroalkyl substances (PFASs) polychlorinated biphenyls (PCBs) measured early pregnancy impaired tolerance (IGT) GDM a Canadian birth...
<h3>Background:</h3> There is growing evidence that seasonal influenza vaccination in pregnancy has benefits for mother and baby. We determined rates among pregnant women during the 2 nonpandemic seasons following 2009 H1N1 pandemic, explored maternal factors as predictors of status evaluated association between neonatal outcomes. <h3>Methods:</h3> used a population-based perinatal database province Nova Scotia, Canada, to examine rates, determinants Our cohort included who gave birth Nov....
Abstract Background Studies in areas with relatively high levels of air pollution have found some positive associations between exposures to ambient and several birth outcomes including low weight (LBW). The purpose this study was examine the association LBW among term infants pollution, by trimester exposure, a region lower level exposures. Methods relationship particulate matter up 10 um diameter (PM ), sulfur dioxide (SO 2 ) ground-level ozone (O 3 evaluated using Nova Scotia Atlee...
In epidemiological studies of environmental exposures and adverse pregnancy outcomes, maternal residence at delivery is often used to assign an exposure level, based on routinely collected data. order examine the potential for misclassification due residential mobility, we examined mobility according changes in overall, as well municipality county. The be related outcomes was considered by examining relationship between risk factors commonly included investigations outcomes. Previously data...
In Brief OBJECTIVE: To identify risk factors for fetuses and neonates with single umbilical artery isolated (single in the absence of chromosomal abnormalities structural abnormalities) to assess whether there is an increased complications during pregnancy, labor, delivery, perinatal morbidity mortality. METHODS: A population-based retrospective cohort analysis deliveries Nova Scotia, Canada, between 1980 2002 was conducted using Scotia Atlee Perinatal Database. Risk outcomes pregnancies...
Increased total homocysteine (tHcy) may be associated with placental-mediated adverse pregnancy outcomes, but few prospective studies have measured tHcy before outcome. This study was undertaken to determine whether increased in early is loss, gestational hypertension (GH), preeclampsia, or small for age (SGA) infants.We conducted a cohort between 2002 and 2005. We serum folate blood samples from pregnant women (<20 weeks' gestation) collected detailed information through questionnaire...
Obesity and type-2 diabetes are on the rise in utero exposure to environmental contaminants is a suspected contributing factor. Our objective was examine associations between prenatal potential endocrine disrupting chemicals markers of fetal metabolic dysfunction. The Maternal-Infant Research Environmental Chemicals Study (MIREC) recruited 2001 women during first trimester pregnancy from 10 Canadian sites. First maternal urine measured for 11 phthalate metabolites bisphenol A (BPA). Leptin...
Anogenital distance (AGD) and the second to fourth finger (2D:4D) digit ratio may be early markers of in utero androgen exposure for infant. Phthalates phenols have been identified as endocrine disrupting chemicals.To study association between prenatal phthalates, bisphenol A (BPA) triclosan (TCS) AGD 2D:4D ratios.Single spot urine samples were collected first trimester from MIREC Study analyzed phthalates phenols. (n = 394) at birth ratios 420) 6 months measured male female infants....