A5088188870- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Nanoparticles: synthesis and applications
- Air Quality Monitoring and Forecasting
- Birth, Development, and Health
- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Noise Effects and Management
- Energy and Environment Impacts
- Analytical Chemistry and Chromatography
- Effects and risks of endocrine disrupting chemicals
- Molecular Biology Techniques and Applications
- Pregnancy and Medication Impact
- Sperm and Testicular Function
- Recycling and utilization of industrial and municipal waste in materials production
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Coal and Its By-products
- Connexins and lens biology
- Biomarkers in Disease Mechanisms
- Heat shock proteins research
- Energy, Environment, and Transportation Policies
- Health, Environment, Cognitive Aging
Health Canada
2016-2025
University of Ottawa
2016-2025
Faculty of Public Health
2025
Carleton University
2022
Analytical Services
2021
North Dakota State University
1985-1990
Studying the physiologic effects of components fine particulate mass (PM2.5) could contribute to a better understanding nature toxicity air pollution. We examined relation between acute changes in cardiovascular and respiratory function, PM2.5-associated-metals. Using generalized linear mixed models, daily ambient PM2.5-associated metals were compared measures 59 healthy subjects who spent 5-days near steel plant on college campus. Interquartile increases calcium, cadmium, lead, strontium,...
The Maternal-Infant Research on Environmental Chemicals (MIREC) Study was established to obtain Canadian biomonitoring data for pregnant women and their infants, examine potential adverse health effects of prenatal exposure priority environmental chemicals pregnancy infant health.Women were recruited during the first trimester from 10 sites across Canada followed through delivery. Questionnaires administered post-delivery collect information demographics, occupation, life style, medical...
Recent epidemiological studies associate health effects and particulate matter in ambient air. Exacerbation of the particle-induced inflammation can be a mechanism responsible for increased hospitalization death due to cardiopulmonary events high-risk groups population. Systems regulating blood pressure that depend on lung integrity involved progression cardiovascular diseases. This study focused expression levels various genes pulmonary diseases assess their role onset problems compared...
Toxicity of airborne particulate matter (PM) is difficult to assess because PM composition complex and variable due source contribution atmospheric transformation. In this study, we used an in vitro toxicoproteomic approach identify the toxicity mechanisms associated with different subfractions Ottawa urban dust (EHC-93).A549 human lung epithelial cells were exposed 0, 60, 140 200 μg/cm2 doses EHC-93 (total), its insoluble soluble fractions for 24 h. Multiple cytotoxicity assays proteomic...
Toxic metals, like lead, are risk factors for preterm birth (PTB), but few studies have examined low levels found in most Canadians. Vitamin D, which may antioxidant activity, protects against PTB. In this study, we investigated the impact of toxic metals (lead, mercury, cadmium and arsenic) on PTB if maternal plasma vitamin D concentrations modify these associations. We whether whole blood measured early late pregnancy were associated with (<37 weeks) spontaneous 1851 live births from...
Background Recent advancements in omics and benchmark dose (BMD) modeling have facilitated identifying the required for a predetermined change response (e.g. gene or protein change) that can be used to establish acceptable levels hazardous exposures. Adverse Outcome Pathways (AOPs) describe causal links between toxicants adverse effects through key events (KEs). Integrating data within AOP framework quantitatively early molecular later phenotypic effects. In this study, we use omic-based BMD...
During pregnancy, women who experience certain pregnancy complications show elevations in biomarkers of inflammation and insulin resistance; however, few studies have examined these cardiometabolic the decade following pregnancy. To examine association between 9 years postpartum including: blood pressure, lipids, body fat percentage, resistance (glucose, insulin, proinsulin, C-peptide, HOMA-IR, HbA1c, leptin, adiponectin) (hs-C-reactive protein). Using data from Maternal-Infant Research on...
There is an emerging interest in incorporating proteomic data for environmental health risk assessments. Meanwhile, the production and use of engineered nanomaterials (ENMs) with attractive physicochemical properties are expanding potential exposure, thus necessitating toxicity information on these materials analysis, where can be informative. Here, cells (A549 human lung epithelial J774A.1 mouse monocyte/macrophage cells) were exposed to ENMs (nanoforms SiO2and TiO2) different sizes surface...
This reply aims to address the comments made by Landwehr and Larcombe [...]
This study combined cytotoxicity assays with proteomic analysis to characterize the unique biological responses of A549 human lung epithelial cell line two physicochemically distinct respirable particles titanium dioxide (TiO2) and carbon black (CB). Cellular LDH, ATP, BrdU incorporation resazurin reduction indicated that CB was more potent than TiO2. Proteomic done using 2D-GE MALDI-TOF-TOF-MS. changes reflected common particle-specific responses. Particle-specific were associated death...
Background: Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that induce immunotoxicity in experimental studies; however, epidemiological evidence—particularly during pregnancy—is scarce. We quantified associations between first trimester plasma perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane (PFHxS) concentrations third of inflammatory biomarkers determined if these were modified by fetal sex. Methods: analyzed data from...
Diesel exhaust particles (DEPs) contribute to air pollution exposure-related adverse health impacts. Here, we examined in vitro, and vivo toxicities of DEPs from a Caterpillar C11 heavy-duty diesel engine emissions using ultra-low-sulfur (ULSD) biodiesel blends (20% v/v) canola (B20C), soy (B20S), or tallow–waste fry oil (B20T) ULSD. The vitro effects (DEPULSD, DEPB20C, DEPB20S, DEPB20T) exposed mouse monocyte/macrophage cells (J774A.1) were by analyzing the cellular cytotoxicity endpoints...
The toxicity of carbon nanotubes (CNTs) has received significant attention due to their usage in a wide range commercial applications. While numerous studies exist on impacts water and soil ecosystems, there is lack information the exposure CNTs from atmosphere. transformation atmosphere, resulting functionalization, may significantly alter toxicity. In current study, chemical modification single wall (SWCNTs) via ozone OH radical oxidation investigated through that simulate expected...
In vitro cytotoxicity assays are essential tools in the screening of engineered nanomaterials (NM) for cellular toxicity. The resazurin live cell assay is widely used because it non-destructive and well suited high-throughput platforms. However, NMs, particular carbon nanotubes (CNT) can interfere through quenching transmitted light or fluorescence. We show that using with time-point reading clarified supernatants resolves this problem. Human lung epithelial (A549) murine macrophage...
Epidemiological studies have shown that as ambient air pollution (AP) increases the risk of cardiovascular mortality also increases. The mechanisms this effect may be linked to alterations in autonomic nervous system function. We wished examine effects industrial AP on heart rate variability (HRV), a measure subtle changes and rhythm representing input heart. Sixty healthy adults were randomized spend five consecutive 8-h days outdoors one two locations: (1) adjacent steel plant Bayview...