A5078346270- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Health Systems, Economic Evaluations, Quality of Life
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Frailty in Older Adults
- Diabetes and associated disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Family and Disability Support Research
- Dermatological and COVID-19 studies
- Health and Lifestyle Studies
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
- Mobile Health and mHealth Applications
- Academic and Historical Perspectives in Psychology
- COVID-19 Impact on Reproduction
- Biosimilars and Bioanalytical Methods
- Mental Health and Psychiatry
- Liver Diseases and Immunity
- Inflammasome and immune disorders
- Respiratory viral infections research
Dalhousie University
2014-2025
Research Canada
2023-2025
Queen Elizabeth II Health Sciences Centre
2018-2024
University of North Carolina at Chapel Hill
2023
Durham VA Medical Center
2023
Emory University
2023
American College of Rheumatology
2023
Rheumatology Consultants
2023
eLearning Studios (United Kingdom)
2023
Center for Rheumatology
2020-2022
<h3>Background:</h3> There is growing evidence that seasonal influenza vaccination in pregnancy has benefits for mother and baby. We determined rates among pregnant women during the 2 nonpandemic seasons following 2009 H1N1 pandemic, explored maternal factors as predictors of status evaluated association between neonatal outcomes. <h3>Methods:</h3> used a population-based perinatal database province Nova Scotia, Canada, to examine rates, determinants Our cohort included who gave birth Nov....
Objective. To construct a Frailty Index (FI) as measure of vulnerability to adverse outcomes among patients with systemic lupus erythematosus (SLE), using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort. Methods. The SLICC cohort consists recently diagnosed SLE followed annually clinical and laboratory assessments. For this analysis, baseline visit was defined first study at which sufficient information available for construction an FI. Following...
Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are at increased risk of cardiovascular disease (CVD). As sedentary behavior lack physical activity known factors, we compared habitual between SLE patients, RA healthy control participants.For this cross-sectional study, patients were recruited from rheumatology clinics an academic medical center April 2013 to December 2014. Healthy participants through local advertising during the same time period. Habitual was...
Objective. To describe organ damage accrual, predictors of progression, and effect on health-related quality life (HRQOL) in patients with systemic lupus erythematosus (SLE). Methods. A longitudinal database who met the American College Rheumatology (ACR) classification criteria for SLE was used. Annual assessments included Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI) Medical Outcomes Study Short Form-36 (SF-36). The prognostic significance demographic,...
Familial chilblain lupus (FCL) is a rare monogenic interferonopathy associated with multiple genetic mutations, including <i>TREX1</i>, characterized by painful, bluish-red skin lesions on acral areas, typically after cold exposure.<sup>1-3</sup> Associated symptoms include inflammatory arthritis, cytopenias, antinuclear antibody (ANA) positivity, and rarely, cerebral aneurysms.<sup>4,5</sup>
To evaluate the properties of a frailty index (FI), constructed using data from Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as novel health measure in systemic lupus erythematosus (SLE).For this secondary analysis, baseline visit was defined first study at which both organ damage (SLICC/American College Rheumatology Damage Index [SDI]) and health-related quality life (Short-Form 36 [SF-36] scores) were assessed. The SLICC-FI data. comprises 48 deficits,...
Using a novel isotemporal substitution paradigm, this study aimed to estimate the cross-sectional associations of objectively measured sedentary behaviour and physical activity (PA) with cardiovascular risk factors among patients SLE.This was adult SLE without documented disease (CVD). Cardiovascular were measured, including BMI, blood pressure, fasting glucose lipid profile. Ten-year CVD estimated using American College Cardiology/American Heart Association assessment tool. Time in...
Objective The Systemic Lupus International Collaborating Clinics ( SLICC ) frailty index FI has been shown to predict mortality, but its association with other important outcomes is unknown. We examined the of baseline values damage accrual in inception cohort. Methods visit was defined as first at which both organ /American College Rheumatology Damage Index [ SDI ]) and health‐related quality life (Short Form 36) were assessed. Baseline scores calculated. measured by increase between...
The Systemic Lupus International Collaborating Clinics (SLICC) is an international research group dedicated to promoting collaboration among scientific investigators in the study of systemic lupus erythematosus (SLE). Currently, most SLICC members are based North America and Europe, with limited representation from other regions. recognises importance expanding its global collaborations ensure that accurately reflects burden SLE provides equal benefit all patients worldwide. Given currently...
Objective The objective is to provide evidence‐based and expert guidance for the screening, treatment, management of lupus nephritis. Methods Core Team developed clinical questions nephritis using PICO format (population, intervention, comparator, outcome). Systematic literature reviews were completed each question, Grading Recommendations Assessment, Development Evaluation (GRADE) methodology was used assess quality evidence formulate recommendations. Voting Panel achieved a consensus ≥70%...
Objective The objective is to provide evidence‐based and expert guidance for the screening, treatment, management of lupus nephritis. Methods Core Team developed clinical questions nephritis using PICO format (population, intervention, comparator, outcome). Systematic literature reviews were completed each question, Grading Recommendations Assessment, Development Evaluation (GRADE) methodology was used assess quality evidence formulate recommendations. Voting Panel achieved a consensus ≥70%...
Objective Cognitive impairment is common in patients with SLE but the cause unknown. The current cross-sectional study examined association between select SLE-related autoantibodies, other serological biomarkers and extensive blood–brain barrier (BBB) leakage without cognitive impairment. In addition, we determined whether relationship differed depending on presence or absence of concurrent BBB leakage. Methods Consecutive SLE, recruited from a single academic medical centre, underwent...
Objective The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) predicts mortality and damage accrual in systemic lupus erythematosus (SLE), but its association with hospitalizations has not been described. Our objective was to estimate the of baseline SLICC‐FI values future SLICC inception cohort. Methods Baseline scores were calculated. number duration inpatient during follow‐up recorded. Negative binomial regression used between rate per patient‐year follow‐up....
The Systemic Lupus International Collaborating Clinics (SLICC), American College of Rheumatology (ACR), and the Foundation America are developing a revised systemic lupus erythematosus (SLE) damage index (the SLICC/ACR Damage Index [SDI]). Shifts in concept SLE have occurred with new insights into disease manifestations, diagnostics, therapy. We evaluated contemporary constructs to inform development SDI.We conducted 3-part qualitative study international experts. Facilitated small groups...
The SLICC frailty index (SLICC-FI) was recently developed as a measure of susceptibility to adverse outcomes in SLE. We aimed externally validate the SLICC-FI prevalent cohort individuals with more long-standing SLE.This secondary analysis included data from single-centre prospective adult patients established SLE (disease duration >15 months at enrolment). baseline visit first which both SLICC/ACR Damage Index (SDI) and 36-item Short Form were available. Baseline scores calculated. Cox...
Objective To externally validate the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC‐FI) in a prevalent systemic lupus erythematosus (SLE) cohort and to assess ability of SLICC‐FI predict organ damage accrual among individuals with longstanding SLE. Methods This was secondary analysis data from Study Vascular Bone Long‐Term Endpoints (SOLVABLE) cohort, which consists adult women Chicago Database who met 1997 revised American College Rheumatology (ACR) classification...
Extensive blood-brain barrier (BBB) leakage has been linked to cognitive impairment in SLE. This study aimed examine the associations of brain functional connectivity (FC) with and BBB dysfunction among patients SLE.Cognitive function was assessed by neuropsychological testing (n = 77). Resting-state FC (rsFC) between regions, measured MRI 78), coordinated neural activation 131 regions across five canonical networks. permeability dynamic contrast-enhanced 61). Differences rsFC were compared...