Noni E. MacDonald

ORCID: 0000-0002-2127-2254
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About
Contact & Profiles
Research Areas
  • Vaccine Coverage and Hesitancy
  • Influenza Virus Research Studies
  • Respiratory viral infections research
  • SARS-CoV-2 and COVID-19 Research
  • Bacterial Infections and Vaccines
  • Misinformation and Its Impacts
  • Pediatric Pain Management Techniques
  • Pneumonia and Respiratory Infections
  • Child and Adolescent Health
  • Virology and Viral Diseases
  • Global Maternal and Child Health
  • Viral Infections and Outbreaks Research
  • Intramuscular injections and effects
  • Ethics and Legal Issues in Pediatric Healthcare
  • Viral gastroenteritis research and epidemiology
  • Reproductive tract infections research
  • COVID-19 epidemiological studies
  • Child Nutrition and Water Access
  • Neonatal Respiratory Health Research
  • Adolescent Sexual and Reproductive Health
  • Cystic Fibrosis Research Advances
  • Tracheal and airway disorders
  • Pharmaceutical studies and practices
  • Immune responses and vaccinations
  • Hepatitis B Virus Studies

Dalhousie University
2016-2025

Izaak Walton Killam Health Centre
2016-2025

University of Ottawa
1991-2021

Children's Hospital of Eastern Ontario
1990-2021

3M (United States)
2015-2021

University of Toronto
2010-2021

SickKids Foundation
1999-2021

University of Geneva
2021

Ottawa Hospital
1994-2021

Public Health Ontario
2021

The SAGE Working Group on Vaccine Hesitancy concluded that vaccine hesitancy refers to delay in acceptance or refusal of vaccination despite availability services. is complex and context specific, varying across time, place vaccines. It influenced by factors such as complacency, convenience confidence. retained the term 'vaccine' rather than 'vaccination' hesitancy, although latter more correctly implies broader range immunization concerns, commonly used term. While high levels lead low...

10.1016/j.vaccine.2015.04.036 article EN cc-by Vaccine 2015-04-17

In March 2012, the SAGE Working Group on Vaccine Hesitancy was convened to define term "vaccine hesitancy", as well map determinants of vaccine hesitancy and develop tools measure address nature scale in settings where it is becoming more evident. The definition a matrix guided development survey tool assess issues. Additionally, questions were piloted annual WHO-UNICEF joint reporting form, completed by National Immunization Managers globally. objective characterizing issues better inform...

10.1016/j.vaccine.2015.04.037 article EN cc-by Vaccine 2015-04-18

For 10 winters, 608 children five years old or younger who were hospitalized with respiratory syncytial virus (RSV) infection prospectively studied to evaluate the relation between their immune status and severity of infection. Forty-seven had been immunocompromised by chemotherapy, steroid therapy, a primary immunodeficiency disorder. Among children, those receiving chemotherapy for cancer disease more severe RSV disease, pneumonia occurring at all ages, higher mortality rate. Children...

10.1056/nejm198607103150201 article EN New England Journal of Medicine 1986-07-10

Occasional reports have suggested that infants with congenital heart disease may an increased risk of severe illness from respiratory syncytial virus (RSV) infection. We prospectively studied 699 hospitalized during the winters 1976 through 1980, when RSV was prevalent in community; 229 these had proved infections acquired either before admission or hospitalization; 27 both and infection, 46 without Infected significantly more than those disease, as judged by requirement for intensive care...

10.1056/nejm198208123070702 article EN New England Journal of Medicine 1982-08-12

In order to gather a global picture of vaccine hesitancy and whether/how it is changing, an analysis was undertaken review three years data available as June 2017 from the WHO/UNICEF Joint Report Form (JRF) determine reported rate across globe, cited reasons for hesitancy, if these varied by country income level and/or WHO region whether were based upon assessment. The classified using Strategic Advisory Group Experts (SAGE) on Immunization matrix determinants...

10.1016/j.vaccine.2018.03.063 article EN cc-by-nc-nd Vaccine 2018-03-28

Excess deaths have occurred among pregnant women during influenza pandemics, but the impact of nonpandemic years is unclear. We evaluated exposure seasons on rates hospital admissions and physician visits because respiratory illness women.We conducted a 13-year (1990-2002) population-based cohort study involving in Nova Scotia. compared office season each trimester pregnancy with year before non-influenza seasons. Poisson regression analyses were performed to estimate rate ratios 95%...

10.1503/cmaj.061435 article EN cc-by-nc-nd Canadian Medical Association Journal 2007-02-12

The Food and Drug Administration recently approved the use of palivizumab (pal-vizh-mäb), an intramuscularly administered monoclonal antibody preparation. Recommendations for its are based on a large, randomized study demonstrating 55% reduction in risk hospitalization attributable to respiratory syncytial virus (RSV) infections high-risk pediatric patients. Infants children with chronic lung disease (CLD), formerly designated bronchopulmonary dysplasia, as well prematurely born infants...

10.1542/peds.102.5.1211 article EN PEDIATRICS 1998-11-01

Despite relatively high vaccination coverage rates in the European Region, vaccine hesitancy is undermining individual and community protection from preventable diseases. At request of its Technical Advisory Group Experts on Immunization (ETAGE), Vaccine-preventable Diseases Programme WHO Regional Office for Europe (WHO/EURO) developed tools to help countries address more effectively. The Guide Tailoring Programmes (TIP), an evidence theory based behavioral insight framework, issued 2013,...

10.1016/j.vaccine.2015.04.038 article EN cc-by Vaccine 2015-04-18

Health communication is an evolving field. There evidence that can be effective tool, if utilized in a carefully planned and integrated strategy, to influence the behaviours of populations on number health issues, including vaccine hesitancy. Experience has shown key points take into account devising implementing plan include: (i) it necessary proactive; (ii) two-way process; (iii) knowledge important but not enough change behaviour; (iv) tools are available selected used creatively promote...

10.1016/j.vaccine.2015.04.042 article EN cc-by Vaccine 2015-04-18

Pain from vaccine injections is common, and concerns about pain contribute to hesitancy across the lifespan.[1][1],[2][2] Noncompliance with vaccination compromises individual community benefits of immunization by contributing outbreaks vaccine-preventable diseases. Individuals

10.1503/cmaj.150391 article EN cc-by-nc-nd Canadian Medical Association Journal 2015-08-24

The current sexually transmitted disease (STD) epidemic in adolescents has led to concern about the potential for spread of human immunodeficiency virus (HIV). In 1988, a total 5514 students first-year community college and university classrooms across Canada were surveyed assess STD/HIV-related knowledge, attitudes, risk behavior. students' mean age was 19.7 years; male-to-female ratio 1:1.4. Students knew more HIV/acquired syndrome than other STDs. Of 74.3% men 68.9% women who coitally...

10.1001/jama.1990.03440230051031 article EN JAMA 1990-06-20

Meningococcal polysaccharide vaccines are not used routinely in infants and toddlers, the groups at highest risk of invasive disease, because poor immunologic responses to Neisseria meningitidis serogroup C these age groups. conjugate offer prospect circumventing this problem.To assess immunogenicity induction memory toddlers by meningococcal vaccine.A multicenter, randomized, observer-blinded controlled trial.Urban suburban family medicine or pediatric practices.Two hundred eleven healthy...

10.1001/jama.280.19.1685 article EN JAMA 1998-11-18

Most Burkholderia cepacia strains are resistant to many, or all, of the antibacterial agents commonly used in cystic fibrosis (CF), and selection appropriate antibiotics for treatment pulmonary exacerbations is therefore difficult. We developed a technique rapid vitro testing multiple antibiotic combinations B. isolates. For each 119 multi-drug-resistant isolates cepacia, our combination bactericidal test (MCBT) studied activity 10 15 antimicrobial using 225 ± 97 single, double, triple...

10.1164/ajrccm.161.4.9907147 article EN American Journal of Respiratory and Critical Care Medicine 2000-04-01

Injections for vaccinations, the most common source of iatrogenic pain in childhood,[1][1] are administered repeatedly to almost all Canadian children throughout infancy, childhood and adolescence.[2][2] The associated with such injections is a distress children, their parents

10.1503/cmaj.101720 article EN cc-by-nc-nd Canadian Medical Association Journal 2010-11-22

Vaccine hesitancy has become the focus of growing attention and concern globally despite overwhelming evidence value vaccines in preventing disease saving lives millions individuals every year. Measuring vaccine its determinants worldwide is important order to understand scope problem for development evidence-based targeted strategies reduce hesitancy. Two indicators assess were developed capture nature at national subnational level collect data 2014: 1) The top 3 reasons not accepting...

10.1371/journal.pone.0172310 article EN cc-by PLoS ONE 2017-03-01
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