A5057366487- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Drug-Induced Ocular Toxicity
- Rheumatoid Arthritis Research and Therapies
- Peripheral Neuropathies and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Liver Diseases and Immunity
- Psoriasis: Treatment and Pathogenesis
- Complement system in diseases
- COVID-19 and Mental Health
- Autoimmune and Inflammatory Disorders Research
- Long-Term Effects of COVID-19
- Inflammatory Bowel Disease
- Blood disorders and treatments
- Liver Disease Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Inflammasome and immune disorders
- Salivary Gland Disorders and Functions
- Adolescent Sexual and Reproductive Health
- Bone and Joint Diseases
Hackensack University Medical Center
2022-2025
Jacobi Medical Center
2024
University of Alabama at Birmingham
2024
Albert Einstein College of Medicine
2013-2022
Montefiore Medical Center
2012-2022
Montefiore Health System
2016
Center for Rheumatology
2015
AECOM (China)
2012
Objective We compared the prevalence and clustering of metabolic syndrome (MetS) components (obese body mass index [BMI; ≥30 kg/m 2 ], hypertriglyceridemia, low high‐density lipids, hypertension, diabetes mellitus) in patients with psoriatic arthritis (PsA) rheumatoid (RA) Consortium Rheumatology Researchers North America (CORRONA) Registry. Methods included CORRONA participants a rheumatologist‐confirmed clinical diagnosis PsA or RA complete data. used modified definition MetS that did not...
Objective. Antiphospholipid antibodies (aPL) play an active role in the pathogenesis of antiphospholipid syndrome (APS). Primary prevention APS may be aimed at decreasing existing elevated aPL levels, or preventing high titers and/or lupus anticoagulant (LAC) from developing first place. Hydroxychloroquine (HCQ) has been shown retrospective studies to decrease laboratory studies, and thrombosis risk patients with systemic erythematosus (SLE). We investigated association between HCQ use...
To compare the incidence rates of malignancy among patients with psoriatic arthritis (PsA) and rheumatoid (RA) in Consortium Rheumatology Researchers North America (CORRONA) registry.We analyzed 2,970 PsA (7,133 patient-years followup) 19,260 RA (53,864 followup). Using a standardized adjudication process, we identified 40 confirmed malignancies 307 those RA. Incidence were calculated per 100 patient-years. rate ratios estimated, adjustment for age, sex, disease duration, body mass index,...
To characterize and compare the factors associated with tubulointerstitial inflammation (TII) scarring, defined as interstitial fibrosis and/or tubular atrophy (IF/TA), in patients lupus nephritis (LN).We identified systemic erythematosus who had renal biopsy results consistent LN between 2005 2017. Clinical data were collected from medical records. Multivariable logistic regression models fitted to assess TII IF/TA (moderate-to-severe versus none/mild).Of 203 included, 41 (20%)...
Objective Due to concerns of infection and medication disruptions during the COVID‐19 pandemic, rheumatology patients at pandemic epicenter were risk distress poor health outcomes. We sought investigate COVID‐19–related in Bronx, New York shortly after peak determine whether factors related associated with flares, disease activity, overall health. Methods In month following epidemic peak, we surveyed adult parents pediatric from clinics Bronx regarding access, interruptions, infection,...
We compared the odds of vitamin D deficiency in three chronic diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and type 2 diabetes (T2DM), adjusting for medications, demographics, laboratory parameters, common to all diseases. also designed multivariate models determine whether different factors are associated with racial/ethnic groups.We identified patients non-overlapping diagnoses SLE, RA, T2DM, 25-hydroxyvitamin (25OHD) levels measured between 2000 2009. Vitamin...
Introduction Treatment failures for lupus nephritis (LN) are high with 10%–30% of patients progressing to end-stage renal disease (ESRD) within 10 years. Interstitial fibrosis/tubular atrophy (IFTA) is a predictor progression ESRD. Prior studies suggest that tubulointerstitial injury secondary proteinuria in LN mediated by complement activation the tubules, specifically through membrane attack complex (MAC). This study aimed investigate associations between tubular MAC deposition IFTA and...
Objective The objective is to provide evidence‐based and expert guidance for the screening, treatment, management of lupus nephritis. Methods Core Team developed clinical questions nephritis using PICO format (population, intervention, comparator, outcome). Systematic literature reviews were completed each question, Grading Recommendations Assessment, Development Evaluation (GRADE) methodology was used assess quality evidence formulate recommendations. Voting Panel achieved a consensus ≥70%...
Lupus nephritis (LN) is one of the most severe manifestations systemic lupus erythematosus (SLE). Interstitial fibrosis/tubular atrophy (IFTA) on kidney biopsies strongly predicts progression to end-stage renal disease although factors associated with IFTA remained unknown. This study aimed evaluate demographic, clinical, and histopathological at time index that are worsening repeat identify potential biomarkers interstitial damage. Patients LN Class I V or mixed who underwent a clinically...
Objective The objective is to provide evidence‐based and expert guidance for the screening, treatment, management of lupus nephritis. Methods Core Team developed clinical questions nephritis using PICO format (population, intervention, comparator, outcome). Systematic literature reviews were completed each question, Grading Recommendations Assessment, Development Evaluation (GRADE) methodology was used assess quality evidence formulate recommendations. Voting Panel achieved a consensus ≥70%...
Objective. In a cohort of systemic lupus erythematosus (SLE) patients with endstage renal failure, to evaluate whether continuing rheumatology followup visits and immunosuppressive therapy after starting replacement were associated increased survival. Methods. We identified all SLE over 21 years old who started between 2005 2011 at an urban tertiary care center. Mortality data obtained using in-hospital records the US Social Security Death Index database. Results. 80 undergoing therapy....
While systemic lupus erythematosus and nephritis (LN) disproportionately affect females, previous studies suggest that males may experience poorer outcomes. We undertook this study to investigate sex differences in health care utilization, end-stage renal disease (ESRD), mortality among patients with LN receiving Medicaid, public insurance for low-income individuals.
Background and objectives Lupus nephritis remains a common cause of morbidity mortality in systemic lupus erythematosus (SLE). Current guidelines recommend performing kidney biopsy at urine protein-creatinine ratio ≥0.5 g/g. However, cross-sectional studies reported high prevalence active histologic lesions, even chronic irreversible scarring, patients with low-grade proteinuria. This study was initiated to assess disease progression SLE proteinuria identify risk factors for overt suggestive...
Objective Although cardiovascular disease (CVD) is the leading cause of death among individuals with rheumatoid arthritis (RA), CVD risks are not being assessed frequently and systematically in RA. We implemented an electronic medical record (EMR)–based reminder a tertiary care center effects this intervention on risk screening by rheumatologists primary providers. Methods The EMR was December 2013 included most recent value target ranges for body mass index, blood pressure (BP), lipid...
Abstract Objectives To compare outcomes by age and sex in race/ethnic minorities presenting with ST‐elevation myocardial infarction (STEMI), as studies are limited. Methods We studied sociodemographics, management, 1208 STEMI patients evaluated for primary percutaneous coronary intervention between 2008 2014 at Montefiore Health System (Bronx, NY). A majority of self‐identified nonwhite, nearly two‐thirds were young (<45 years) or middle‐aged (45‐64 years). Results Risk factors varied...
Using American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC) criteria for systemic lupus erythematosus (SLE) classification as gold standards, we determined sensitivity, specificity, positive negative predictive values (PPV NPV) having SLE denoted the primary cause end-stage renal disease (ESRD) in US Renal Data System (USRDS).ESRD patients were identified by Classification Diseases, Ninth Revision codes electronic medical records 1 large...
Abstract Background Lupus nephritis (LN) is one of the most severe manifestations systemic lupus erythematosus (SLE). Interstitial fibrosis/tubular atrophy (IFTA) on kidney biopsies strongly predicts progression to end-stage renal disease. However, factors associated with IFTA are not known. The objective this study was evaluate demographic, clinical, and histopathological at time index that worsening repeat biopsies. Methods Patients LN Class I V or mixed who underwent a clinically...