A5079704368- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- Ion channel regulation and function
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Neural dynamics and brain function
- Cardiac electrophysiology and arrhythmias
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neural Engineering
- Metabolism and Genetic Disorders
- Meteorological Phenomena and Simulations
- Psychosomatic Disorders and Their Treatments
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Cardiac Arrhythmias and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolomics and Mass Spectrometry Studies
- Bacterial Infections and Vaccines
- Climate variability and models
- Glycogen Storage Diseases and Myoclonus
- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
SickKids Foundation
2010-2025
University of Toronto
2014-2025
Hospital for Sick Children
2012-2025
Pontificia Universidad Católica del Ecuador
2025
Mental Health Research Canada
2017-2024
Universidade de Rio Verde
2021
The University of Texas at El Paso
2006-2019
The University of Texas at Austin
2017
University of California, San Francisco
2016
Canadian Wildlife Federation
2010
We treated 19 patients with Rasmussen9s syndrome (chronic encephalitis and epilepsy)–a rare progressive disorder of unknown etiology causing focal epilepsy, hemiparesis, intellectual deterioration–with intravenous immunoglobulins, high-dose steroids, or both, to control seizures improve the end point disease. Ten 17 receiving eight nine had some reduction seizure frequency in short term. Improvement hemiparesis was slight. The effect these drugs ameliorating disease long term remains...
The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is principal mediator of synaptic plasticity. Here we report that neuropilin tolloid-like 1 (Neto1), complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, novel component NMDAR complex critical for maintaining abundance NR2A-containing NMDARs postsynaptic density. Neto1-null mice have depressed long-term potentiation (LTP) at Schaffer...
Bipolar disorder is a debilitating psychopathology with unknown etiology. Accumulating evidence suggests the possible involvement of Na + ,K -ATPase dysfunction in pathophysiology bipolar disorder. Here we show that Myshkin mice carrying an inactivating mutation neuron-specific α3 subunit display behavioral profile remarkably similar to patients manic state. increased Ca 2+ signaling cultured cortical neurons and phospho-activation extracellular signal regulated kinase (ERK) Akt hippocampus....
In a mouse mutagenesis screen, we isolated mutant, Myshkin (Myk), with autosomal dominant complex partial and secondarily generalized seizures, greatly reduced threshold for hippocampal seizures in vitro, posttetanic hyperexcitability of the CA3-CA1 pathway, neuronal degeneration hippocampus. Positional cloning functional analysis revealed that Myk/+ mice carry mutation (I810N) which renders normally expressed Na(+),K(+)-ATPase alpha3 isoform inactive. Total activity was by 42% brain. The...
Lafora disease is the most common teenage-onset neurodegenerative disease, main form of progressive myoclonus epilepsy (PME), and one severest epilepsies. Pathologically, a starch-like compound, polyglucosan, accumulates in neuronal cell bodies overtakes small processes, mainly dendrites. Polyglucosan formation catalyzed by glycogen synthase, which activated through dephosphorylation glycogen-associated protein phosphatase-1 (PP1). Here we remove PTG, proteins that target PP1 to glycogen,...
Abstract The ketogenic diet (KD), a treatment for drug‐resistant epilepsy, elevates brain acetone. Acetone has been shown to suppress experimental seizures. Whether elevation of acetone is the basis anticonvulsant effects KD and whether acetone, like KD, antagonizes many different types seizures, however, unknown. This study investigated spectrum in animal seizure models. Rats were injected with intraperitoneally. Dose–response measured four models: (1) maximal electroshock test, which...
Social interactions are essential to our mental health, and a deficit in social is hallmark characteristic of numerous brain disorders. Various subregions within the medial temporal lobe have been implicated memory, but underlying mechanisms that tune these neural circuits remain unclear. Here, we demonstrate optical activation excitatory entorhinal cortical perforant projections dentate gyrus (EC-DG) necessary sufficient for memory retrieval. We further show inducible disruption...
Deletion of the LIMK1 gene is associated with Williams syndrome, a unique neurodevelopmental disorder characterized by severe defects in visuospatial cognition and long-term memory (LTM). However, whether contributes to these deficits remains elusive. Here, we show that LIMK1-knockout (LIMK1(-/-)) mice are drastically impaired LTM but not short-term (STM). In addition, LIMK1(-/-) selectively defective late-phase potentiation (L-LTP), form long-lasting synaptic plasticity specifically...
Lafora disease (LD) is a fatal and the most common form of adolescent-onset progressive epilepsy. Fulminant endoplasmic reticulum (ER)-associated depositions starch-like long-stranded, poorly branched glycogen molecules [known as polyglucosans, which accumulate to bodies (LBs)] are seen in neuronal perikarya dendrites, liver, skeletal muscle heart. The caused by loss function laforin dual-specificity phosphatase or malin E3 ubiquitin ligase. Towards understanding pathogenesis polyglucosans...
Summary: Purposes: To determine the occurrence of nonconvulsive seizures (NCS) in Pediatric Intensive Care Unit (PICU); to ascertain relationship NCS past medical history, etiology, EEG, and brain imaging; concordance between abnormal EEG findings neuroimaging abnormalities. Methods: A retrospective review was conducted all pediatric patients who were admitted or transferred PICU from January 2000 December 2003 with an unexplained decrease level consciousness, no overt clinical seizures,...
Significance Comprehensive clinical, neurological, and genetic examinations characterized a generalized myoclonic epilepsy syndrome with photosensitivity in young Rhodesian Ridgeback dogs. The average age of onset seizures was 6 mo. Genetic analyses revealed defective DIRAS family GTPase 1 ( DIRAS1 ) gene protein. is widely expressed the brain has been suggested to regulate acetylcholine release play role neurodevelopment. This study reveals candidate for human epilepsies, translational...
El hecho administrativo, su definición está, de hecho, relacionado con el derecho del empleador ejercer dirección, debido en especial a ello. organizar, dirigir y controlar los empleados, pero manera proporcionada otros trabajadores las regulaciones legales. Por lo tanto, esta investigación, diferencia se busca reconocer administrativo comparación conceptos. A partir aquí, teniendo una idea mencionados anteriormente, primero es sin formalidad puede ser un desencadenante la consecuencia...
Objectives: This retrospective study enrolled consecutive children aged 2-18 years with developmental and/or epileptic encephalopathy continuous spike and wave during sleep (D)EE-SWAS who received oral high-dose diazepam therapy. Their clinical, electroencephalographic (EEG), radiologic data were reviewed summarized. Results: Thirty-five eligible patients identified. The mean age at EEG diagnosis of was 6 years. Focal seizures (57.1%) most commonly noted the time diagnosis. A definite...
We made a pathologic diagnosis of chronic encephalitis on surgical resections or autopsy material in 10 patients with intractable seizures and studied the specimens by immunohistochemistry for herpes simplex virus (HSV) 1 2 cytomegalovirus (CMV) as well polymerase chain reaction (PCR) viral DNA sequences (HSV1, HSV2, CMV). also assessed eight (nonepileptic) pathologically documented clinically suspected five from epileptics without encephalitis. Immunohistochemistry antigens was negative all...
<b><i>Objective and background:</i></b> Atypical absence seizures differ markedly from typical in EEG findings, ictal behavior, neurodevelopmental outcome. The object of these experiments was to provide electrical, behavioral, pharmacologic, developmental characterization a putative animal model atypical seizures. <b><i>Methods:</i></b> were induced Long Evans hooded rats by treatment with cholesterol biosynthesis inhibitor, AY-9944 (AY), during development. Prolonged video recordings made...
Type I diabetes and multiple sclerosis (MS) are distinct autoimmune diseases where T cells target either islet or CNS self-proteins. Unexpectedly, we found that autoreactive in diabetic patients, relatives with high risk, nonobese (NOD) mice, MS patients routinely classical as well autoantigens. The pathogenic potential of autoreactivity was testable NOD mice. Pertussis holotoxin, without additional Ags adjuvants, allowed development an mouse-specific, encephalitis variable...
PURPOSE: We examined the effect of safranal, a constituent Crocus sativus, in acute experimental animal models generalized absence seizures. METHODS: further characterized its effects on GABAergic system through regional modification [3H] flunitrazepam, benzodiazepine agonist binding site and CGP54626A, GABAB receptor antagonist mouse brain. RESULTS: The systemic administration safranal resulted significant dose-dependent attenuation seizures elicited by either ?-butyrolactone (GBL),...
Background and Purpose— In neonates, the differentiation of stroke hypoxic ischemic encephalopathy (HIE) is important. Neuroimaging presents technical challenges in unstable resulting frequently delayed or missed diagnosis stroke. Differentiating clinical electroencephalographic (EEG) features would assist physicians timely diagnosis. We sought to determine, neonates with seizures, EEG that differentiate HIE. Methods— Retrospective cohort study comparing clinical, seizure, term HIE seizures...
Background Poor agreement between observers on whether an unusual event is a seizure drives the need for specific diagnostic tool provided by video‐electroencephalography (video‐ EEG ) in human pediatric epileptology. Objective That successful classification of events would be positively associated with increasing recording length and higher frequency reported before video‐ evaluation; that novel wireless technique clarify behavioral were seizures unsedated dogs. Animals Eighty‐one...
Epilepsy and autism spectrum disorders (ASD) are two distinct brain but have a high rate of co-occurrence, suggesting shared pathogenic mechanisms. Neuroligins cell adhesion molecules important in synaptic function ASD, their role epilepsy remains unknown. In this study, we show that Neuroligin 2 (NLG2) knockout mice exhibit abnormal spike wave discharges (SWDs) behavioral arrests characteristic absence seizures. The anti-absence seizure drug ethosuximide blocks SWDs rescues social memory...