A5024881582- Adolescent and Pediatric Healthcare
- Autoimmune and Inflammatory Disorders Research
- Ethics in Clinical Research
- Delphi Technique in Research
- Patient-Provider Communication in Healthcare
- Smoking Behavior and Cessation
- Childhood Cancer Survivors' Quality of Life
- Appendicitis Diagnosis and Management
- Ethics and Legal Issues in Pediatric Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
- Intestinal Malrotation and Obstruction Disorders
- Child and Adolescent Health
- Meningioma and schwannoma management
- Emergency and Acute Care Studies
- Behavioral Health and Interventions
- Global Cancer Incidence and Screening
- Epilepsy research and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmaceutical studies and practices
- Spinal Fractures and Fixation Techniques
- Obesity, Physical Activity, Diet
- Rheumatoid Arthritis Research and Therapies
- Infant Development and Preterm Care
- Health Promotion and Cardiovascular Prevention
University of Liverpool
2016-2025
Carleton University
2021-2025
Czech Academy of Sciences, Institute of Psychology
2018
Roy Castle Lung Cancer Foundation
2015
The COVID-19 pandemic has imposed a wide variety of unprecedented challenges, many which appear to be disproportionately affecting the mental health and well-being young adults. While there is evidence suggest university students experience high rates disorders, less known about specific impacts on student how they are coping with this stress. To address gap, we conducted an online study among undergraduate ( n = 366) examine impact academics, social isolation, health, as well extent have...
While non-operative treatment has emerged as an alternative to surgery for the of uncomplicated acute appendicitis in children, comparative patient-centred outcomes are not well documented. We investigated these a feasibility randomised trial. Of 57 participants, data were available 26. Compared with appendicectomy, children allocated reported higher short-term quality life scores, shorter duration requiring analgesia, more rapid return normal activities and parental absence from work. These...
Background Although non-operative treatment is known to be effective for the of uncomplicated acute appendicitis in children, randomised trial data comparing important outcomes with those appendicectomy are lacking. Objectives The objectives were ascertain feasibility conducting a multicentre controlled clinical effectiveness and cost-effectiveness pathway children. Design This was mixed-methods study, which included trial, embedded parallel qualitative survey studies, health economic study...
Abstract Male territorial-sneaker polymorphisms are common in nature. To understand how these evolve, we developed a game theoretical model analogous to the classical Hawk-Dove model, but with two important differences. First, allowed non-uniform interaction rates of strategies account for possibility that some interactions between male disproportionately more frequent than others. Second, females exhibit preference one type and thereby choose mates adaptively. Selection dynamics were...
Aims The Bracing Adolescent Idiopathic Scoliosis (BASIS) study is a randomized controlled non-inferiority pragmatic trial of ‘full-time bracing’ (FTB) compared to ‘night-time (NTB) for the treatment adolescent idiopathic scoliosis (AIS). We anticipated that recruiting patients BASIS would be challenging, as it paediatric comparing two markedly different bracing pathways. No previous studies have experiences AIS treated with FTB those NTB. This qualitative was embedded in explore families’...
Objectives The UK ambulance service is expected to now manage more patients in the community and avoid unnecessary transportations hospital emergency departments (ED). Most people it attends who have experienced seizures established epilepsy, uncomplicated so do not require full facilities of an ED. Despite this, most are transported there. To understand why, we explored paramedics’ experiences managing seizures. Design setting Semistructured interviews were conducted with a purposive sample...
Abstract Background Research studies to inform clinical practice and policy in children young people with appendicitis are hampered by inconsistent selection reporting of outcomes. The aim this study was develop a core outcome set for all uncomplicated acute people. Methods Systematic literature reviews, qualitative interviews parents patients treated appendicitis, Study-Specific Advisory Group informed long list Outcomes were then prioritized stakeholders based the UK (patients, parents,...
Currently, the routine treatment for acute appendicitis in United Kingdom is an appendicectomy. However, there increasing scientific interest and research into non-operative of adults children. While a number studies have investigated adults, this cannot be applied to paediatric population. Ultimately, we aim perform UK-based multicentre randomised controlled trial (RCT) test clinical cost effectiveness uncomplicated children, as compared with First, will undertake feasibility study assess...
Objective To establish the feasibility of a multicentre randomised controlled trial to assess effectiveness and cost-effectiveness non-operative treatment pathway compared with appendicectomy in children uncomplicated acute appendicitis. Design Feasibility embedded qualitative study inform recruiter training optimise recruitment design future definitive trial. Setting Three specialist paediatric surgery centres UK. Patients Children (aged 4–15 years) clinical diagnosis Interventions...
Smoking cessation following lung cancer diagnosis has been found to improve several patient outcomes. Electronic cigarette (e-cigarette) use is now prevalent within Great Britain, however, and practice among patients with not as yet explored. The current study aims explore e-cigarette examine clinicians. results have important implications for future policy practice. Members of British Thoracic Oncology Group (BTOG) were contacted via e-circulations (N = 2,009), requesting them complete an...
Abstract Introduction Providing balanced information that emphasizes clinical equipoise (i.e., uncertainty regarding the relative merits of trial interventions) and exploring patient treatment preferences can improve informed consent recruitment. Within a comparing adjuvant radiotherapy versus active monitoring following surgical resection for an atypical meningioma (ROAM/EORTC-1308), we explored patterns in communication reasons why health practitioners may find it challenging to convey...
Objectives Electronic cigarettes (e‐cigarettes) are promoted as smoking cessation tools, yet they remain unavailable from S top moking ervices in E ngland; the debate over their safety and efficacy is ongoing. This study was designed to explore perceptions reasons for use or non‐use of electronic among individuals engaged ervices. Methods Semi‐structured telephone interviews were undertaken with twenty participants north‐west ngland. Participants comprised both who had tried e‐cigarettes ( n...
Objectives We explored children’s views on research without prior consent (RWPC) and sought to identify ways of involving children in discussions. Design Qualitative interview study. Setting Participants were recruited through a UK hospital online advertising. 16 aged 7–15 years with diagnosis asthma (n=14) or anaphylaxis (n=2) recent (<12 months) experience emergency care. Results Children keen be included medical viewed RWPC as acceptable situations if trial interventions judged safe....
Introduction: Electronic cigarette (e-cigarette) use rose substantially within the UK in recent years but currently, Stop Smoking Services England do not prescribe them due to a lack of regulation. Previous research has examined e-cigarette and attitudes English using samples practitioners managers; current study recruited sample service users. Methods: Participants (N = 319) aged 18–60 old were from Roy Castle FagEnds, Liverpool, (Stop Service). A cross-sectional questionnaire was...
Introduction The UK ambulance service often attends to suspected seizures. Most persons attended will not require the facilities of a hospital emergency department (ED) and so should be managed at scene or by using alternative care pathways. though are transported ED. One factor that helps explain this is paramedics can have low confidence in managing Objectives With view ultimately developing additional seizure management training for practicing paramedics, we explored their learning needs,...
Plain English summary Researchers test treatments to ensure these work and are safe. They do this by studying the effects that have on patients measuring outcomes, such as pain quality of life. Often research teams measure different outcomes even though each team is same condition. This makes it hard compare findings from studies can reduce accuracy treatment advice available patients. Increasingly, researchers tackling problem developing ‘core outcome sets’. These lists all working a given...
Abstract Background Recruiting patients to paediatric trials can be challenging, especially in that compare markedly different management pathways and are conducted acute settings. We aimed enhance informed consent recruitment the CONTRACT trial (CONservative TReatment of Appendicitis Children a randomised controlled Trial; ISRCTN15830435) – feasibility compared non-operative treatment (antibiotics) versus appendicectomy for uncomplicated appendicitis. Methods Qualitative study embedded...
<h3>Introduction</h3> In recent years, there has been growing interest in alternatives to appendicectomy. particular, non-operative treatment of appendicitis, with antibiotics alone, proposed as a potential treatment. A small number randomised controlled trials (RCTs) adults and, more recently, children suggest that antibiotic may be valid alternative However, is currently insufficient data justify its widespread use. Prior performing further efficacy studies the appendicitis children, it...
Purpose: The current project sought to examine whether delivery of lung cancer risk projections (calculated using the Liverpool Lung Project [LLP] model) predicted follow-up smoking status. Design: Two single-blinded randomized controlled trials. Setting: Stop Smoking Services in (United Kingdom). Participants: Baseline smokers (N = 297) and baseline recent former 216) were recruited. Intervention: Participants allocated intervention groups provided with personalized projections, calculated...
Patient recruitment can be very challenging in paediatric studies, especially relatively uncommon conditions, such as juvenile idiopathic arthritis (JIA). However, involving children and young people (CYP) the design of trials could promise a more rapid trajectory towards making evidence-based treatments available. Studies CYP are advocated literature but we not aware any early stage feasibility studies that have qualitatively accessed perspectives parents with long term condition to inform...
Abstract Background Sodium valproate (VPA) has been associated with a reduced risk of head and neck cancer development. The potential protective mechanism action is believed to be via inhibition histone deacetylase subsequent epigenetic reprogramming. SAVER phase IIb open-label, randomised control trial VPA as chemopreventive agent in patients high-risk oral epithelial dysplasia (OED). aim the gather preliminary evidence clinical biological effects upon OED assess feasibility acceptability...
Chronic exposure to high circulating glucocorticoid or ghrelin concentrations increases food intake, weight gain and adiposity, suggesting that could contribute the metabolic effects of chronic glucocorticoids. In male mice, however, blocking receptor (GHSR) signaling increased adiposity induced by corticosterone (CORT), rather than attenuating them. current study, we investigated role GHSR in CORT female mice. To do this, WT KO mice were treated with either a 1% ethanol (EtOH) solution EtOH...
Background The association between smoking and several health outcomes among those from the most deprived communities in UK has not previously been detailed. aim of this study is to examine impact on specifically a particularly population developed country (Liverpool; one local authorities England). Methods Liverpool Lung Project recruited prospective cohort 8753 participants across Liverpool, aged 45–79 years 1998 2008. Participants were followed annually through Hospital Episode Statistics...
Understanding patient and health practitioner perspectives on clinical trials can inform opportunities to enhance trial conduct design, therefore experience. Patients with haematological cancers have faced additional risk uncertainty during the pandemic but it is unclear how they practitioners experienced cancer this period. In context of a haemato-oncology (PETReA), we compared views experiences PETReA before COVID-19.Qualitative study embedded within PETReA. Semi-structured interviews...
In the UK, juvenile idiopathic arthritis is most common inflammatory disorder in childhood, affecting 10 : 100,000 children and young people aged < 16 years each year, with a population prevalence of around 1 1000. Corticosteroids are commonly used to treat arthritis; however, there currently lack consensus as which corticosteroid induction regimen should be various disease subtypes severities arthritis.The main study objective was determine feasibility conducting randomised controlled trial...