A5054508057- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Musculoskeletal Disorders and Rehabilitation
- Child and Adolescent Health
- Innovations in Medical Education
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Rheumatoid Arthritis Research and Therapies
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Kawasaki Disease and Coronary Complications
- Pharmaceutical studies and practices
- Neurogenetic and Muscular Disorders Research
- Nursing Roles and Practices
- Inflammasome and immune disorders
- Salivary Gland Disorders and Functions
- Family and Disability Support Research
- Hip disorders and treatments
- Eosinophilic Esophagitis
- Diversity and Career in Medicine
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Orthopedic Infections and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Diabetes and associated disorders
Newcastle University
2015-2024
Human Technopole
2023
Institute for Musculoskeletal Health
2022
The University of Sydney
2022
Aga Khan University
2022
Newcastle University Medicine Malaysia
2019-2021
Great North Children's Hospital
2012-2020
Newcastle upon Tyne Hospitals NHS Foundation Trust
2011-2020
University of Newcastle Australia
2014-2018
Newcastle upon Tyne Hospital
2000-2016
Abstract Objective To compare the safety and efficacy of parenteral methotrexate (MTX) at an intermediate dosage (15 mg/m 2 /week) versus a higher (30 in patients with polyarticular‐course juvenile idiopathic arthritis (JIA) who failed to improve while receiving standard dosages MTX (8–12.5 /week). Methods In screening phase, 595 were newly started on dose followed up for 6 months. Subsequently, nonresponders, defined according American College Rheumatology (ACR) pediatric 30% improvement...
Anterograde intraflagellar transport (IFT) trains are essential for cilia assembly and maintenance. These formed of 22 IFT-A IFT-B proteins that link structural signaling cargos to microtubule motors import into cilia. It remains unknown how the IFT-A/-B arranged complexes these polymerize functional trains. Here we use in situ cryo-electron tomography Chlamydomonas reinhardtii AlphaFold2 protein structure predictions generate a molecular model entire anterograde train. We show conformations...
Objectives To investigate the validity and feasibility of Juvenile Arthritis Disease Activity Score (JADAS) in routine clinical setting for all juvenile idiopathic arthritis (JIA) disease categories explore whether exclusion erythrocyte sedimentation rate (ESR) from JADAS (the ‘JADAS3’) influences correlation with single markers activity. Methods JADAS-71, JADAS-27 JADAS-10 were determined at baseline an inception cohort children JIA Childhood Prospective Study. JADAS3-71, JADAS3-27...
We describe pGALS (paediatric Gait, Arms, Legs and Spine) - a simple quick musculoskeletal assessment to distinguish abnormal from normal joints in children young people. The use of is aimed at the non-specialist paediatric medicine as basic clinical skill be used conjunction with essential knowledge about red flags, development awareness patterns pathologies. has been validated school-aged also context acute general paediatrics detect joints. propose that an important part skills acquired...
Objectives To evaluate the long-term efficacy and safety of canakinumab in patients with active systemic juvenile idiopathic arthritis (JIA). Methods Patients (2–19 years) entered two phase III studies continued extension (LTE) study. Efficacy assessments were performed every 3 months, including adapted JIA American College Rheumatology (aJIA-ACR) criteria, Juvenile Arthritis Disease Activity Score (JADAS) ACR clinical remission on medication criteria (CR ). analyses are reported as per...
Abstract Background Musculoskeletal (MSK) conditions are a major source of morbidity and disability. There is lack global comparable data on the burden MSK in children young people. Our aim was to estimate prevalence three - Talipes Equinovarus (Clubfoot), Juvenile Idiopathic Arthritis (JIA) Systemic Lupus Erythematosus (JSLE). Methods Using reported rates, age-stratified population within World Bank Data 2017 United Nations country classification, we estimated these < 5 year olds...
Abstract Objective To document pathways of care, management, and interval from onset symptoms to first pediatric rheumatology multidisciplinary team (PRhMDT) assessment for children with incident juvenile idiopathic arthritis (JIA). Methods We conducted a retrospective observational study JIA over 3‐year period. Results The included 152 patients (87 females). median symptom PRhMDT was 20 weeks (range 0–416), significant variation between subtypes ( P = 0.0097); extended oligoarticular had...
Objective. Inflammatory arthritis in childhood is variable terms of both presentation and outcome. This analysis describes disease activity children with juvenile idiopathic (JIA) during the first year following to a paediatric rheumatologist identifies predictors moderate severe disability [defined using Childhood HAQ (CHAQ) score ⩾0.75] at 1 year.
Objectives. To study the association between disease severity at first presentation to paediatric rheumatology (PRh) and length of time since symptom onset in children recruited Childhood Arthritis Prospective Study.
Objectives. The medical management of JIA has advanced significantly over the past 10 years. It is not known whether these changes have impacted on outcomes. aim this analysis was to identify and describe trends in referral times, treatment times 1-year outcomes a 10-year period among children with enrolled Childhood Arthritis Prospective Study. Methods. Study prospective inception cohort new-onset inflammatory arthritis. Analysis included all recruited 2001–11 at least 1 year follow-up,...
Objective To evaluate the demographic, disease activity, disability, and health‐related quality of life (HRQOL) differences between children with juvenile idiopathic arthritis (JIA) their healthy peers, JIA without clinical temporomandibular joint (TMJ) involvement its determinants. Methods This study is based on a cross‐sectional cohort 3,343 3,409 enrolled in Pediatric Rheumatology International Trials Organisation HRQOL or methotrexate trial. Potential determinants TMJ included measures...
To determine if depressive symptoms assessed near diagnosis associate with future measures of pain, disability and disease for adolescent patients diagnosed JIA.Data were analysed from JIA aged 11-16 years recruited to the Childhood Arthritis Prospective Study, a UK-based inception cohort childhood-onset arthritis. Depressive (using Mood Feelings Questionnaire; MFQ), active limited joint count, score (Childhood Health Assessment Questionnaire), pain visual analogue scale patient's general...
Despite the profound burden of disease, a strategic global response to optimise musculoskeletal (MSK) health and guide national-level systems strengthening priorities remains absent. Auspiced by Global Alliance for Musculoskeletal Health (G-MUSC), we aimed empirically derive requisite components action on MSK health.
We have documented the initial clinical features of 100 patients with primary Sjöigren's syndrome (SS) together results their baseline investigations. The evolution disease in these has been followed for a median 34 months (range 3–84 months). majority were females aged 40–60 years, and common included eye symptoms (100%), xerostomia polyarthralgia (94%), Raynaud's phenomenon (81%) salivary gland swelling (47%). Thyroid was relatively (14%) while other endocrine rare. Four died during...
We describe the collaborative development of an evidence based, free online resource namely 'paediatric musculoskeletal matters' (pmm). This was developed with aim reaching a wide range health professionals to increase awareness, knowledge and skills within paediatric medicine, thereby facilitating early diagnosis referral specialist care. Engagement stakeholder groups (primary care, paediatrics, specialties medical students) informed essential 'core' learning outcomes derive content pmm....
Objectives Pain is a very common symptom of juvenile idiopathic arthritis (JIA). Disease activity alone cannot explain symptoms pain in all children, suggesting other factors may be relevant. The objectives this study were to describe the different patterns experienced over time children with JIA and identify predictors which are likely experience ongoing pain. Methods This used longitudinal-data from patients (aged 1–16 years) new-onset JIA. Baseline up 5-year follow-up data Childhood...
To assess European pediatric rheumatology providers' current clinical practices and resources used in the transition from child-centered to adult-oriented care. rheumatologists were invited complete a 17-item anonymized e-survey assessing practices, policy awareness, needs advance of publication EULAR/PReS recommendations on transition. The response rate was 121/276 (44%), including responses 115 centers 22 Union countries. Although 32/121 (26%) responded that their did not offer services,...