A5044389756- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Bone health and osteoporosis research
- Musculoskeletal Disorders and Rehabilitation
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Hip and Femur Fractures
- Nutrition and Health in Aging
- COVID-19 Clinical Research Studies
- Hip disorders and treatments
- Chronic Disease Management Strategies
- COVID-19 and healthcare impacts
- Vitamin D Research Studies
- Child and Adolescent Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Diversity and Career in Medicine
- Innovations in Medical Education
- Health Systems, Economic Evaluations, Quality of Life
- Gout, Hyperuricemia, Uric Acid
- Bone and Joint Diseases
- Monoclonal and Polyclonal Antibodies Research
- Parkinson's Disease and Spinal Disorders
- Tuberculosis Research and Epidemiology
- Bone fractures and treatments
- Inflammasome and immune disorders
University of Cape Town
2013-2024
Groote Schuur Hospital
1995-2022
Royal National Hospital for Rheumatic Diseases
2022
University of KwaZulu-Natal
2022
Center for Rheumatology
2015
Merck & Co., Inc., Rahway, NJ, USA (United States)
2002
City of Cape Town
2001
University of South Africa
1988
Abstract Objective. To evaluate trabecular bone mineral density (BMD) in young ambulatory female patients with systemic lupus erythematosus (SLE). Methods. Bone (gm/cm 2 ) at the lumbar vertebrae (L1–L4) and left femur (neck, trochanter, intertrochanter, Ward's triangle) was measured by dual x‐ray absorptiometry 46 SLE (mean age 31 years, mean disease duration 76 months) 108 healthy controls 32 years). Twenty‐two of were receiving corticosteroids (CS) time study. Results. Lumbar BMD less...
Despite the profound burden of disease, a strategic global response to optimise musculoskeletal (MSK) health and guide national-level systems strengthening priorities remains absent. Auspiced by Global Alliance for Musculoskeletal Health (G-MUSC), we aimed empirically derive requisite components action on MSK health.
Opioids are increasingly used in the treatment of chronic non-malignant pain. The aim this open-label, randomised, parallel group study was to compare analgesia and side-effects two commonly opioid analgesics, tramadol dihydrocodeine, long-acting formulations 60 osteoarthritis patients with strong pain despite NSAID's. Dose titration based on effect performed respective immediate release solutions given additionally 100 mg bid dihydrocodeine during first 4 days 1 month treatment. Electrical...
Abstract Musculoskeletal (MSK) health impairments contribute substantially to the pain and disability burden in low- middle-income countries (LMICs), yet systems strengthening (HSS) responses are nascent these settings. We aimed explore contemporary context, framed as challenges opportunities, for improving population-level prevention management of MSK LMICs using secondary qualitative data from a previous study exploring HSS priorities globally (2) contextualize findings through primary...
Background Systemic lupus erythematosus (SLE) is a life-threatening multisystem autoimmune disease that more severe in patients of African ancestry and children, yet pediatric SLE on the continent has been understudied. This study describes cohort (PULSE) South Africa. Methods Patients with diagnosis (1997 American College Rheumatology criteria) diagnosed prior to age 19 years Cape Town, Africa, were enrolled this cross-sectional from September 2013 December 2014. Information clinical...
Updated treatment recommendations for the therapy of rheumatoid arthritis (RA) in South Africa advocate early diagnosis, prompt initiation disease-modifying anti-rheumatic drugs (DMARDs), and an intense strategy where disease activity is assessed with a composite score such as Simplified Disease Activity Index (SDAI). Frequent assessments escalation are necessary until low (LDA) (SDAI ≤ 11) or ideally remission 3.3) achieved. Synthetic DMARDs may be used monotherapy combination, can...
A cross sectional analysis of the correlation between clinical, laboratory, and radiological markers disease activity in 98 patients with classical rheumatoid arthritis (RA) is reported. The median age was 38 years, at onset 29 duration seven years. Keitel function test (KFT) showed good Ritchie articular index (RAI) (p less than 0.0001; r = 0.5) disability questionnaire (DQ) 0.6). RAI DQ correlated weakly laboratory variables, while KFT significant erythrocyte sedimentation rate (ESR), C...
Abstract Objectives To identify the changes in rheumatology service delivery across five regions of Africa from impact COVID-19 pandemic. Methods The African Rheumatology Study Group created an online survey consisting 40 questions relating to current practices and experiences rheumatologists Africa. CHERRIES checklist for reporting results internet e-surveys was adhered to. Results A total 554 completed responses were received 20 countries, which include six Northern Africa, West four...
The primary aim of the CHANGE survey is to determine current state gender equity within rheumatology, and secondarily, review physician perspective on bullying, harassment equipoise opportunities rheumatology. e-survey a cross-sectional self-reported questionnaire adapted from EULAR's in academic rheumatology task force. was launched January 2023; it available six languages distributed widely via organizations social media. Eligible participants include rheumatologist physicians health-care...
Objective : To evaluate the efficacy and tolerability of rofecoxib 25 mg 50 once daily versus placebo naproxen 500 twice in patients with RA. Methods Eligible were randomized (double-blind) to (n = 289), 306), 286) daily, or 142) for 12 weeks. Efficacy assessments included ACR core set, prespecified primary endpoints: patient investigator global disease activity, tender swollen joint counts. Investigator-reported adverse experiences, routine laboratory vital sign measurements monitored....
The hip fracture rates in South Africa were used to create ethnic-specific FRAX® models facilitate risk assessment.The aim of this study was develop FRAX compute the 10-year probability and major osteoporotic assess their potential clinical application.Age- sex-specific incidence national mortality incorporated into a model for White, Black African, Coloured Indian population Africa. Age-specific probabilities calculated women determine at femoral neck T score -2.5 SD, or those equivalent...
Osteoporosis in RA is mediated by numerous inflammatory substances. This study was undertaken to see if SAARD could modify the rate of metacarpal bone loss RA. Combined cortical thickness (CCT) measured at midshaft right second used calculate mass (CA%) using a digitizer. Eighty-one subjects were studied, all whom had least three sets hand X-rays, last which approximately 18 months following initiation therapy. There 12 males and 69 females. The mean age time starting therapy 51 (SD 12)...
Actions towards the health-related Sustainable Development Goal 3.4 typically focus on non-communicable diseases (NCDs) associated with premature mortality, less emphasis NCDs disability, such as musculoskeletal conditions-the leading contributor to global burden of disability.