A5083525330- Systemic Lupus Erythematosus Research
- Viral Infections and Immunology Research
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Tuberculosis Research and Epidemiology
- Spondyloarthritis Studies and Treatments
- Pregnancy and preeclampsia studies
- Musculoskeletal Disorders and Rehabilitation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Renal Diseases and Glomerulopathies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Vascular Procedures and Complications
- Diversity and Career in Medicine
- Neonatal Respiratory Health Research
- Escherichia coli research studies
- Coronary Interventions and Diagnostics
- COVID-19 Clinical Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Hematological disorders and diagnostics
- Mycobacterium research and diagnosis
- Pericarditis and Cardiac Tamponade
- Telemedicine and Telehealth Implementation
Stellenbosch University
2015-2024
Tygerberg Hospital
2007-2024
Clinical Emergency Hospital Bucharest
2023
University of Bahri
2023
Center for Rheumatology
2015-2022
South African Medical Research Council
1992
To determine the prevalence and specificity of anticyclic citrullinated peptide antibodies (anti-CCP) rheumatoid factor (RF) for arthritis (RA) in human immunodeficiency virus (HIV) infection to evaluate effect immune reconstitution on these markers.Patients with advanced HIV without were enrolled. CD4+ T lymphocyte counts (CD4), anti-CCP, RF determined before initiating antiretroviral therapy (ART) repeated after 6 months. Results compared those healthy controls. Patients followed...
African American ethnicity is independently associated with lupus myocarditis compared other ethnic groups. In the mixed racial population of Western Cape, South Africa, no data exists on clinical features/outcome myocarditis.The objective this study was to give a comprehensive description features and outcome acute in population.Clinical records (between 2008 2014) adult systemic erythematosus (SLE) patients at tertiary referral centre were retrospectively screened for echocardiographic...
A method is described for the routine preparation of sputum samples detection Mycobacterium tuberculosis by using polymerase chain reaction amplification. Liquefaction with NaOH and subsequent removal inhibitors a 50% sucrose centrifugation step (5 min) in desktop centrifuge allow direct amplification 123-bp repetitive region M. genome. We have evaluated sensitivity specificity 155 specimens from patients suspected having normal healthy volunteers. This method, our opinion, reproducible,...
This report describes a DNA amplification procedure for routine identification of heat-labile-toxin-producing Escherichia coli. Two oligonucleotide primers were used in polymerase chain reaction to amplify highly conserved region the A subunit heat-labile enterotoxin gene. Amplifications done directly on E. coli colonies from plates when Salmonella, Shigella, or parasite infections excluded as agents severe diarrhea patients. The conditions method empirically determined, and is inexpensive,...
To identify cytokines, markers of endothelial activation [soluble vascular cell adhesion molecule-1 (sVCAM-1)] and myocyte strain ST2 (sST2)] associated with myocardial injury (MInj) in SLE, classified by cardiac magnetic resonance (CMR) criteria.CMR was performed on patients identifying stages MInj (inflammation necrosis or fibrosis). Data captured included: clinical assessment, laboratory serological analyses, cytokine (IL-1β, IL-1Ra, IL-2, IL-6, IL-10, IL-17, IL-18, TNF-alpha), sVCAM-1...
Aims Lupus myocarditis occurs in 5–10% of patients with systemic lupus erythematosus (SLE). No single feature is diagnostic myocarditis. Speckle tracking echocardiography (STE) can detect subclinical left ventricular dysfunction SLE patients, limited research on its utility clinical We report STE comparison to conventional Methods and results A retrospective study was done at a tertiary referral hospital South Africa. were included compared healthy controls. Echocardiographic images...
Objectives To determine the outcome of subclinical lupus myocarditis (LM) over twelve months with regards to: mortality; incidence clinical LM and change in imaging parameters (echocardiography cardiac magnetic resonance [CMR]). evaluate impact immunosuppression on CMR evidence myocardial tissue injury. Methods SLE patients without injury (as per 2009 Lake Louise criteria [LLC]) were included. Analysis at baseline follow-up included: evaluation, laboratory analyses CMR). Clinical was defined...
Introduction The outbreak of the SARS-CoV-2 virus causing COVID-19, declared a global pandemic by WHO, is novel infection with high rate morbidity and mortality. In South Africa, 55 421 cases have been confirmed as 10 June 2020, most in Western Cape Province. Coronavirus leaves us position uncertainty regarding best clinical approach to successfully manage expected number severely ill patients COVID-19. This presents unique opportunity gather data inform practices public health interventions...
Background. Integrated positron emission tomography/computed tomography (PET-CT) is a well-validated modality for assessing pulmonary mass lesions and specifically estimating risk of malignancy. Tuberculosis (TB) known to cause false-positive PET-CT findings. Objective. To investigate the utility in evaluation nodules high TB prevalence setting. Methods. All patients referred solitary nodule or who underwent scanning over 3-year period were included. The findings, including maximum...
We report the first known South African case of fibroblastic rheumatism, a rare dermatoarthropathy. Our patient presented with typical clinical features sudden-onset, erosive polyarthritis cutaneous nodules and sclerodactyly. Significant functional loss occurred within period 3 to 4 months. X-rays hands showed single erosion, whereas magnetic resonance imaging further erosions as well soft tissue synovial enhancement. The unique histologic findings proliferation, thickened collagen, dermal...
Objectives To determine the prevalence of myocardial injury (MInj) in systemic lupus erythematosus (SLE) according to cardiac magnetic resonance (CMR) criteria. compare clinical and echocardiographic features patients with without MInj identify predictors tissue characteristics CMR. Methods SLE inpatients underwent CMR screening for based on Lake Louise Criteria (LLC). Tissue included inflammation (increased T2-weighted signal or early gadolinium enhancement ratio (EGEr)) necrosis fibrosis...
Cyclophosphamide (CPM) is still considered to be the first-line treatment for many life-threatening autoimmune conditions. It does, however, carry a significant risk of serious adverse events, especially infections. At present CPM administered as either daily oral dose (DOC) or an intravenous pulse (PIVC). There uncertainty regarding safety profiles both regimens in settings with high burden infectious diseases.To compare frequency and nature events related use DOC PIVC such setting.A cohort...
<h3>Objective</h3> A large body of literature suggests that prevention fibrosis – which contributes to chronicity lupus nephritis (LN) - may significantly improve long-term prognosis. Bone morphogenetic protein-7 (BMP-7) was first identified as a therapeutic option in this context decades ago and evidence its benefit the various conditions, including LN, is ever-increasing. Despite these facts, BMP-7 not being implemented therapy renal disease. Our objective understand hurdles implementation...
<h3>Background</h3> Lupus myocarditis (LM) is a rare but potentially fatal complication occurring in 5–10% of patients with systemic lupus erythematosus (SLE). Endomyocardial biopsy (EMB) regarded as the diagnostic gold-standard for invasive and validated context non-rheumatological myocarditis. 2D-echocardiography cardiac magnetic resonance (CMR) incorporating T1 T2-mapping, are non-invasive tools used to evaluate Current international guidelines on use EMB CMR based research done...