A5004741225- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Healthcare cost, quality, practices
- Ion Transport and Channel Regulation
- Potassium and Related Disorders
- Renal and Vascular Pathologies
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Global Maternal and Child Health
- Diet and metabolism studies
- Healthcare Systems and Reforms
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Tuberculosis Research and Epidemiology
- Healthcare Policy and Management
- Acute Kidney Injury Research
- Long-Term Effects of COVID-19
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Chronic Lymphocytic Leukemia Research
- Parathyroid Disorders and Treatments
Tygerberg Hospital
2015-2024
Stellenbosch University
2015-2024
University of Cape Town
2002-2024
South African Tuberculosis Vaccine Initiative
2024
South African Medical Research Council
2024
Western Cape Department of Health
2015-2023
Renal Association
2020
University College London
2008
Great Ormond Street Hospital
2008
Hillingdon Hospital
2008
There is a dearth of data on end-stage renal disease (ESRD) in Africa. Several national registries have been established but not sustainable because resource limitations. The African Association Nephrology (AFRAN) and the Paediatric (AFPNA) recognize importance good registry plan to establish an Renal Registry. This article reviews elements needed for successful gives overview developed developing countries, with emphasis It then discusses proposed Registry first steps towards its...
The increasing prevalence of treated end-stage renal disease and low transplant rates in Africa leads to longer durations on dialysis. Dialysis should not only be aimed at prolonging lives but also improve quality life (QOL). Using mixed methods, we investigated the QOL patients chronic haemodialysis (HD) peritoneal dialysis (PD).We conducted a cross-sectional study Tygerberg Hospital Cape Town, South Africa. All PD were being with continuous ambulatory KDQOL-SF 1.3 questionnaire was used...
During the outbreak of coronavirus disease 2019 (COVID-19), many studies have investigated laboratory biomarkers in management and prognostication COVID-19 patients, however to date, few arterial blood gas, acid-base pressure patterns. The aim study is assess gas patterns, findings their association with outcomes patients admitted an intensive care unit.A single-centre retrospective, observational a dedicated unit Cape Town, South Africa. Admission serum electrolytes, renal function readings...
The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related quality life (QOL) has become an essential outcome measure for patients with CKD end stage renal (ESRD). There growing interest QOL but paucity data Ghana. This study sought to assess moderate advanced (not on dialysis) establish its determinants. We conducted a cross sectional observational at the outpatient clinic Komfo Anokye Teaching Hospital (KATH). collected demographic, clinical...
The eighth annual report of the South African Renal Registry summarises 2019 data on kidney replacement therapy (KRT) for patients with failure in Africa. This round collection has been adversely affected by COVID-19 pandemic, which impacted completeness data. In December 2019, number who were being treated chronic dialysis or transplantation stood at 9 937, a prevalence 169 per million population (pmp). Africans accessing private healthcare sector was 788 pmp, whereas it 57 pmp chronically...
Abstract Airborne transmission of SARS-CoV-2 aerosol remains contentious. Importantly, whether cough or breath-generated bioaerosols can harbor viable and replicating virus largely unclarified. We performed size-fractionated sampling (Andersen cascade impactor) evaluated viral culturability in human cell lines (infectiousness), genetics, host immunity ambulatory participants with COVID-19. Sixty-one percent (27/44) 50% (22/44) emitted variant-specific culture-positive aerosols <10μm...
Optimizing the usability of e-learning materials is necessary to reduce extraneous cognitive load and maximize their potential educational impact. However, this often neglected, especially when time other resources are limited. We conducted a randomized trial investigate whether evaluation our multimedia resource, followed by fixing all problems identified, would translate into improvements in parameters learning medical residents. Two iterations resource [ version 1 (V1) 2 (V2)] were...
Introduction An effective workforce is essential for optimal care of all forms chronic diseases. The objective this study was to assess capacity kidney failure (KF) across world countries and regions. Methods Data were collected from published online sources a survey administered key stakeholders. All country-level data analysed by International Society Nephrology region World Bank income classification. Results general healthcare varies level: high-income have more workers per 10 000...
This article reports on the development and evaluation of a Web-based application that provides instruction hands-on practice in managing electrolyte acid-base disorders. Our teaching approach, which focuses concepts rather than details, encourages quantitative analysis logical problem-solving approach. Identifying any dangers to patient is vital first step. Concepts such as an “appropriate response” given perturbation need for electroneutrality body fluids are used repeatedly. Electrolyte...
Optimizing the usability of e-learning materials is necessary to maximize their potential educational impact, but this often neglected when time and other resources are limited, leading release that cannot deliver desired learning outcomes. As clinician-teachers in a resource-constrained environment, we investigated whether heuristic evaluation our multimedia resource by panel experts would be an effective efficient alternative testing with end users. We engaged six inspectors, whose...
Abstract Background Preliminary studies have shown the potential use of salivary creatinine concentration in diagnosis chronic kidney disease (CKD). For saliva to replace serum as a diagnostic tool, must be done determine its effectiveness and staging CKD. The aim present study was evaluate safe non-invasive alternative for identifying patients with Methods A cross-sectional conducted at Tygerberg Hospital Cape Town, on 230 patients, across all stages Ethical approval conduct obtained from...
<b><i>Background:</i></b> Hyperkalemia is a common medical emergency that may result in serious cardiac arrhythmias. Standard therapy with insulin plus glucose reliably lowers the serum potassium concentration ([K<sup>+</sup>]) but carries risk of hypoglycemia. This study examined whether an intravenous glucose-only bolus [K<sup>+</sup>] stable, nondiabetic, hyperkalemic patients and compared this intervention insulin-plus-glucose therapy....
The majority of South Africans rely on a resource-constrained public healthcare sector, where access to renal replacement therapy (RRT) is strictly rationed. incidence RRT in this sector only 4.4 per million population (pmp), whereas it 139 pmp the private which serves mainly 16% who have medical insurance. Data outcomes may influence policies and resource allocation. This study evaluated, for first time, survival African patients starting based data from Renal Registry.The cohort included...