A5100662270- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Helicobacter pylori-related gastroenterology studies
- Extracellular vesicles in disease
- Acute Kidney Injury Research
- MicroRNA in disease regulation
- Organ Donation and Transplantation
- Cancer-related molecular mechanisms research
- Healthcare Systems and Reforms
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Clostridium difficile and Clostridium perfringens research
- Gastric Cancer Management and Outcomes
- Pancreatic function and diabetes
- Single-cell and spatial transcriptomics
- Renal and Vascular Pathologies
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Spinal Fractures and Fixation Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Global Maternal and Child Health
- Diabetes and associated disorders
West China Medical Center of Sichuan University
2025
Huazhong University of Science and Technology
2021-2024
Tongji Hospital
2021-2024
Zhongda Hospital Southeast University
2017-2024
University of Alberta
2016-2024
First Affiliated Hospital of Guangzhou Medical University
2013-2024
National Clinical Research
2024
Guangzhou Medical University
2013-2024
Icahn School of Medicine at Mount Sinai
2020-2024
Nanjing Medical University
2014-2023
<h3>Importance</h3> Kidney disease is a substantial worldwide clinical and public health problem, but information about available care limited. <h3>Objective</h3> To collect on the current state of readiness, capacity, competence for delivery kidney across countries regions world. <h3>Design, Setting, Participants</h3> Questionnaire survey administered from May to September 2016 by International Society Nephrology (ISN) 130 ISN-affiliated with sampling key stakeholders (national nephrology...
Recently, extracellular vesicles (EVs) have been attracting strong research interest for use as natural drug delivery systems. We report an approach to manufacturing interleukin-10 (IL-10)-loaded EVs (IL-10+ EVs) by engineering macrophages treating ischemic acute kidney injury (AKI). Delivery of IL-10 via enhanced not only the stability IL-10, but also its targeting due adhesive components on EV surface. Treatment with IL-10+ significantly ameliorated renal tubular and inflammation caused...
Background/Aims: Non-coding RNAs including miRNA and lncRNA had been reported to regulate gene expression were both related cancer progression. MicroRNA-141 (miR-141) has play a role in the epithelial mesenchymal transition (EMT) process H19 also demonstrated promote malignancy various cancers. We aimed determine correlation between miR-141 their roles gastric this study. Methods: detected by qRT-PCR. By bioinformatic analysis luciferase assay we examined vitro. Results: was found be...
Albuminuria is a key instigator of tubulointerstitial inflammation associated with CKD, but the mechanism through which filtered albumin propagates renal injury remains unclear. In this study, we explored role in process exosome mRNA released from tubular epithelial cells (TECs). Compared control mice, acute and chronic kidney models had more exosomes containing inflammatory cytokine mRNA, particularly chemokine CCL2, kidneys urine. vitro stimulation TECs BSA recapitulated finding. Notably,...
Abstract Numerous substrates have been identified for Type I and II arginine methyltransferases (PRMTs). However, the full substrate spectrum of only type III PRMT, PRMT7, its connection to PRMT remains unknown. Here, we use mass spectrometry reveal features PRMT7-regulated methylation. We find that PRMT7 predominantly methylates a glycine motif; multiple methylation sites are close phosphorylations sites; proximal sequences vulnerable cancer mutations; is enriched in proteins associated...
Abstract Metformin, one of the most common prescriptions for patients with type 2 diabetes, is reported to protect kidney from gentamicin-induced nephrotoxicity. However, role and mechanisms metformin in preventing cisplatin-induced nephrotoxicity remains largely unknown. In this study, a single intraperitoneal injection cisplatin was employed induce acute injury (AKI) CD1 mice. The mice exhibited severe dysfunction histological damage at day after injection. Pretreatment could markedly...
Although glucocorticoids are the mainstays in treatment of renal diseases for decades, dose dependent side effects have largely restricted their clinical use. Microvesicles (MVs) small lipid-based membrane-bound particles generated by virtually all cells. Here we show that RAW 264.7 macrophage cell-derived MVs can be used as vectors to deliver dexamethasone (named MV-DEX) targeting inflamed kidney efficiently. Methods: macrophages were incubated with and then MV-DEX was isolated from...
M2 macrophage polarization is known to underlie kidney fibrosis. We previously reported that most of the members Wnt family signaling proteins are induced in fibrotic kidneys. Dysregulation protein Wnt5a associated with fibrosis, but little about role regulating activation results Here, using murine Raw 264.7 cells and bone marrow-derived macrophages, we found enhanced transforming growth factor β1 (TGFβ1)-induced as well expression transcriptional regulators Yes-associated...
An understanding of the health care resource use associated with AKI is needed to frame investment and cost-effectiveness strategies prevent promote kidney recovery.We assembled population-based cohort adults hospitalized in Alberta between November 2002 March 2009 without ESRD or an eGFR<15 ml/min per 1.73 m2. Outpatient serum creatinine measurements 6 months preceding admission defined baseline function, during first 14 days hospitalization Acute Kidney Injury Network stage; recovery as...
Abstract During embryogenesis, the liver is site of hepatogenesis and hematopoiesis contains many cell lineages derived from endoderm mesoderm. However, characteristics developmental programs these remain unclear, especially in humans. Here, we performed single-cell RNA sequencing whole human mouse fetal livers throughout development. We identified four lineage families endoderm-derived, erythroid, non-erythroid hematopoietic, mesoderm-derived non-hematopoietic cells, defined pathways major...
Intestinal metaplasia (IM) is the inevitable precancerous stage to develop intestinal-type gastric cancer (GC). Deoxycholic acid (DCA) main bile (BA) component of duodenogastric reflux and has shown an increased concentration during transition from chronic gastritis IM associated with continued STAT3 activation. However, mechanisms underlying how DCA facilitates in epithelium need exploration. We evaluated corpus tissues 161 subjects undergoing GC screening. Cell survival proliferation,...
ABSTRACT Background Conservative kidney management (CKM) describes supportive care for people living with failure who choose not to receive or are unable access replacement therapy (KRT). This study captured the global availability of CKM services and funding. Methods Data came from International Society Nephrology Global Kidney Health survey conducted between June September 2022. Availability CKM, infrastructure, guidelines, medications training were evaluated. Results was available in some...
In this study, 5-fluorouracil (5-FU) and LY294002 (LY)-loaded PEGylated nanoliposome was prepared to target esophageal squamous cell carcinoma (ESCC). The particles were characterized in terms of physicochemical biological parameters. co-delivery autophagy inhibitor chemotherapeutic drug a single carrier successfully accomplished. two components from 5-FU LY-loaded (FLNP) released controlled manner with LY relatively faster compared that 5-FU. FLNP showed receptor-mediated cellular uptake...
Abstract Quercetin, a flavonoid found in wide variety of plants and presented human diet, displays promising potential preventing kidney fibroblast activation. However, whether quercetin can ameliorate fibrosis mice with obstructive nephropathy the underlying mechanisms remain to be further elucidated. In this study, we that administration could largely interstitial macrophage accumulation kidneys nephropathy. MTORC1, mTORC2, β-catenin as well Smad signaling were activated kidneys, whereas...
Our previously published study demonstrated that mammalian target of rapamycin complex 2 (mTORC2) signaling mediates TGFβ1-induced fibroblast activation. However, the underlying mechanisms for mTORC2 in stimulating activation remain poorly understood. Here, we found TGFβ1 could stimulate and Yap/Taz NRK-49F cells. Blocking either or diminished In addition, blockade down-regulate expression Yap/Taz, connective tissue growth factor (CTGF), ankyrin repeat domain 1 (ANKRD1). Overexpression...