A5025025478- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Esophageal and GI Pathology
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Histone Deacetylase Inhibitors Research
- Gastrointestinal Tumor Research and Treatment
- Digestive system and related health
- Oral health in cancer treatment
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Kruppel-like factors research
- Clostridium difficile and Clostridium perfringens research
- Anorectal Disease Treatments and Outcomes
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal disorders and treatments
- Sinusitis and nasal conditions
- Glioma Diagnosis and Treatment
- Hydrogen's biological and therapeutic effects
Nanjing Medical University
2019-2023
Jiangsu Province Hospital
2019-2023
Nantong University
2017
Intestinal metaplasia (IM) is the inevitable precancerous stage to develop intestinal-type gastric cancer (GC). Deoxycholic acid (DCA) main bile (BA) component of duodenogastric reflux and has shown an increased concentration during transition from chronic gastritis IM associated with continued STAT3 activation. However, mechanisms underlying how DCA facilitates in epithelium need exploration. We evaluated corpus tissues 161 subjects undergoing GC screening. Cell survival proliferation,...
Abstract Circular RNAs (circRNAs) play a vital role in the occurrence and development of tumors, including gastric cancer (GC). However, there are still many circRNAs related to GC whose functions molecular mechanisms remain undetermined. Herein, we discover circRNA RELL1, which has not been investigated GC, it is markedly downregulated tissues, with poor prognosis, more pronounced lymph node metastasis TNM stage. After confirming circular structure circRELL1, found that circRELL1 could...
Mutations of isocitrate dehydrogenase 1 and 2 (IDH1 IDH2) gene were recently discovered in vast majority World Health Organization (WHO) grade II/III gliomas. This study is to understand the effects IDH1 R132H mutation gliomagenesis develop new strategies treat glioma with mutation.Over expression U87MG cells was done by transfecting plasmid. MTT assay, scratch repair assay western blot performed on cell proliferation, migration, regulating AKT-mTOR signaling pathway death respectively....
Circular (circ)RNAs are widely involved in gastric cancer (GC) pathogenesis, and coiled-coil domain containing 6 (CCDC6) is a fused partner of multiple oncogenes; however, the underlying mechanisms how circRNAs regulate CCDC6 expression progression prognosis GC remain unclear. Here, we discovered circRNA derived from DNA2 gene locus (circDNA2) through RNA sequencing. By performing quantitative real-time PCR fluorescence situ hybridization (FISH) assays with human tissue microarray, circDNA2...
Abstract Background After the failure of clarithromycin- and bismuth-based quadruple therapy (CBQT), levofloxacin- (LBQT) is recommended for Helicobacter pylori eradication. We compared efficacies second-line tailored (TBQT) empirical LBQT. Methods Patients with CBQT were randomly assigned to receive TBQT or LBQT 14 days. All patients underwent endoscopy culture-based antibiotic susceptibility testing. in group exhibiting levofloxacin randomized amoxicillin, levofloxacin, esomeprazole,...
Endoscopic submucosal dissection has been widely applied for curative resection of early gastric cancer or high-grade dysplasia, and metachronous is a major issue after endoscopic therapy. Here, we studied the recurrence patterns its correlation with primary lesions.A total 286 consecutive patients undergoing dysplasia between March 2011 2018 were retrospectively reviewed. Metachronous was defined as new detected more than 1 year dissection.During median follow-up 36 months, 24 developed...
Abstract Rationale: Antibiotic resistance poses a challenge for Helicobacter pylori eradication treatment. Current guidelines strongly recommend avoiding repeated treatments with the same antibiotic to prevent emergence of drug resistance. However, penicillin-allergic patients recurrent H. failures, severely limits choice Patient concerns: A 47-year-old woman penicillin allergy whom 2 previous levofloxacin and bismuth-based therapies had failed. Diagnosis: infection. Interventions: Agar...