Abstract Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are regarded as useful tools for cancer detection, particularly the early stage; however, little is known about their diagnostic impact on gastric (GC). We hypothesized GC-related lncRNAs might release into circulation during tumor initiation and could be utilized to detect monitor GC. 8 which previously found differently expressed in GC were selected candidate targets subsequent circulating lncRNA assay. After...

Background/Aims: Non-coding RNAs including miRNA and lncRNA had been reported to regulate gene expression were both related cancer progression. MicroRNA-141 (miR-141) has play a role in the epithelial mesenchymal transition (EMT) process H19 also demonstrated promote malignancy various cancers. We aimed determine correlation between miR-141 their roles gastric this study. Methods: detected by qRT-PCR. By bioinformatic analysis luciferase assay we examined vitro. Results: was found be...

Increasing evidence showed that miRNAs serve as modulators of human cancer, either oncogene or tumor suppressors. Cisplatin resistance is the most common cause chemotherapy failure in gastric cancer (GC). However, roles cisplatin GC remain largely unknown. The aim study was to identify a novel miRNA/gene pathway regulates sensitivity cells cisplatin.In this study, we chose miR-223 by qRT-PCR analysis, significantly up-regulated miRNA GC, investigate its formation DDP-resistant phenotype and...

Abstract Background Gut dysbacteriosis has been reported as one of the etiologies for irritable bowel syndrome (IBS). However, association between gut microbiota and IBS is still inconclusive. Method A paired-sample study was designed by retrieving original multicenter 16 s-rRNA data patients healthy controls from GMrepo database. The propensity score matching (PSM) algorithm applied to reduce confounding bias. differential analysis composition performed at different taxonomic levels....

Aim . The aim of this study was to investigate the prevalence and risk factors H. pylori infection in areas with high gastric cancer Jiangsu Province, China. Methods A prospective epidemiologic survey accomplished a natural population 5417 individuals Yangzhong city. Questionnaires 13C-urea breath test for were performed. Results Among subjects who completed questionnaires test, 3435 (63.41%) positive. reached peak at age 30–39 years (90.82%). There significant difference between sexes women...

// Xiaoying Zhou 1, 2, * , Han Chen Li Zhu 3, Bo Hao 1 Weifeng Zhang Jie Hua Huiyuan Gu 4 Wujuan Jin 2 Guoxin Department of Gastroenterology, First Affiliated Hospital Nanjing Medical University, Nanjing, China Clinical College 3 People's Jingjiang, Taizhou, Soochow Suzhou, These authors contributed equally to this work Correspondence to: Zhang, email: guoxinz@njmu.edu.cn Keywords: helicobacter pylori infection, lncRNA, gastric cancer, MUC2 Received: April 27, 2016 Accepted: October 10,...

Background: The association between Helicobacter pylori infection and gastric cancer has been identified recently. However, the molecular mechanism remained largely unknown. Methods Results: We found that miR-141 was decreased in positive specimens (n=75) compared with negative tissues (n=75). knockdown of enhanced invasion ability cells; meanwhile, over-expression could inhibit abilities cells vitro. A luciferase assay revealed directly bound to 3'-untranslated regions (3'-UTR) STAT4. STAT4...

Several microRNAs (miRNA) have been implicated in H. pylori related gastric cancer (GC). However, the molecular mechanism of miRNAs has not fully understood. In this study, we reported that miR-101 is significantly down-regulated positive tissues and cells tumor with important functional consequences. Ectopic expression dramatically suppressed cell proliferation colony formation by inducing G1-phase cell-cycle arrest. We found strongly reduced SOCS2 oncogene GC cells. Similar to restoring...

Dysregulation of microRNAs (miRNAs) play critical roles in cancerous processes. Although miR-3064 was reported to be an important tumor suppressor ovarian cancer, the cellular impact on pancreatic cancer (PC) progression, its downstream target genes and upstream mechanisms that control expression remain fully clarified. We compared miRNA profiles between PC tissues with normal using a microarray analysis clinical samples, screened identified miRNAs for their influence cell proliferation....

Background: Several studies have identified an association between the gut microbiome and post-stroke depression(PSD), Helicobacter pylori(H. pylori) infection cause significant alterations in composition of gastrointestinal microbiome. However, evidence regarding role H. pylori promoting PSD is still lacking. Here, we conducted a retrospective study to explore risk factors associated with PSD. Methods: Patients cerebral infarction were consecutively enrolled from December 2021 October 2022....

Pharmacognosy Magazine,2011,7,25,65-68.DOI:10.4103/0973-1296.75904Published:January 2011Type:Original ArticleAuthors:Shuge Tian, Yang Shi, Xiaoying Zhou, Liang Ge, and Halmuart Upur Abstract:Objective: This paper investigates the total polyphenolic flavonoid content as well antioxidant activity of Ziziphora clinopodioides Lam. extracts different polarity. Materials Methods: The was analysed using Folin-Ciocalteu method. Total analysis performed colorimetric Results: Z. is concentrated in...

// Xiaoying Zhou 1,2,* , Guifang Xu 3,* Chengqiang Yin 1,2 Wujuan Jin and Guoxin Zhang 1 Department of Gastroenterology, First Affiliated Hospital Nanjing Medical University, Nanjing, China 2 Clinical College 3 Drum Tower University School, * These authors contributed equally to the work Correspondence: Zhang, email: Keywords : miR-203; CASK; Helicobacter pylori; gastric cancer Received August 17, 2014 Accepted October 18, Published Abstract Several microRNAs (miRNA) have been implicated in...

Background The molecular mechanism between Helicobacter pylori (H. pylori) infection and gastric cancer remained largely unknown. In this study, we determined the role of miRNA in H. induced cancer. Methods Results We found that miR-204 was decreased positive tissues by qRT-PCR. Knockdown enhanced invasion proliferation ability cells vitro. Luciferase assay revealed SOX4 target gene miR-204, which up-regulated tissues. Down-regulation over-expression promoted epithelial-mesenchymal...

Growing evidence has shown that altered gut microbiota is associated with the pathogenesis of COVID-19, but their causal effects are still unclear. We conducted a bidirectional Mendelian randomization (MR) study to assess on COVID-19 susceptibility or severity, and vice versa. The microbiome genome-wide association studies (GWAS) data 18 340 individuals GWAS statistics from host genetics initiative (38 984 European patients 1 644 784 controls) were used as exposure outcomes. inverse variance...

Abstract Background Oral microbiome dysbacteriosis has been reported to be associated with the pathogenesis of advanced esophageal cancer. However, few studies investigated potential role oral and gastric microbiota in early-stage intramucosal squamous carcinoma (EIESC). Method A total 104 samples were collected from 31 patients EIESC 21 healthy controls. The compositions analyzed using 16 S rRNA V3-V4 amplicon sequencing. Linear discriminant analysis effect size (LEfSe) was performed assess...