A5029204775- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Testicular diseases and treatments
- RNA Research and Splicing
- Cancer Research and Treatments
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Galectins and Cancer Biology
- Bladder and Urothelial Cancer Treatments
- Bone and Dental Protein Studies
- Renal and related cancers
- Immune Cell Function and Interaction
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Cancer Cells and Metastasis
- Mycobacterium research and diagnosis
- Gastroesophageal reflux and treatments
- Plant and Fungal Interactions Research
- Digestive system and related health
Reproductive & Genetic Hospital CITIC-Xiangya
2020-2025
Central South University
2015-2024
National Engineering Research Center of Human Stem Cells
2018-2024
Shanxi Medical University
2024
CITIC Group (China)
2022
Xiangya Hospital Central South University
2018-2021
National Health and Family Planning Commission
2021
Third Xiangya Hospital
2015-2020
Sun Yat-sen University
2020
Zhongshan Hospital
2020
// Hao Bo 1,2,3 , Zhaojian Gong 2,4 Wenling Zhang 2 Xiayu Li 3 Yong Zeng 1 Qianjin Liao Pan Chen Lei Shi 4 Yu Lian Yizhou Jing Ke Tang Zheng Yanhong Zhou Ming Xiang Xiaoling Jianbo Yang 1,5 Wei Xiong Guiyuan and Zhaoyang Hunan Cancer Hospital The Affiliated of Xiangya School Medicine, Central South University, Changsha, Hunan, China Key Laboratory Carcinogenesis the Chinese Ministry Health Invasion Education, Research Institute, Nonresolving Inflammation Cancer, Disease Genome Center, Third...
Actin filament-associated protein 1 antisense RNA (AFAP1-AS1), a long noncoding RNA, is significantly highly expressed and associated with metastasis poor prognosis in many cancers, including nasopharyngeal carcinoma (NPC). In this study, we aim to identify the role of AFAP1-AS1 acting as an oncogenic lncRNA promote NPC metastasis. The AFAP1-AS1, miR-423-5p, FOSL2 was investigated vitro vivo. Bioinformatics analysis luciferase activity assays were used interaction between FOSL2....
Long noncoding RNAs (lncRNAs) have emerged as a major regulator of cancer. Significant fraction lncRNAs is represented on widely used microarray platforms; however, many which no known function. To discover novel lung cancer-related lncRNAs, we analyzed the lncRNA expression patterns in five sets previously published cancer gene profile data that were Affymetrix HG-U133 Plus 2.0 array, and identified dysregulated One lncRNA, actin filament associated protein 1 antisense RNA1 (AFAP1-AS1), was...
Epstein-Barr virus (EBV) infection is causatively related to a variety of human cancers, including nasopharyngeal carcinoma (NPC) and gastric cancer (GC). EBV encodes 44 mature miRNAs, number which have been proven promote carcinogenesis by targeting host genes or self-viral genes. However, in this study, we found that an EBV-encoded microRNA, termed EBV-miR-BART6-3p, inhibited EBV-associated cell migration invasion NPC GC reversing the epithelial-mesenchymal transition (EMT) process. Using...
Background and Aims Hepatocellular carcinoma (HCC) is associated with high malignancy rates. Recently, a known deacetylase silent information regulator 1 (SIRT1) was discovered in HCC, its presence positively correlated metastasis. N 6 ‐methyladenosine (m A) the most prominent modification, but exact mechanisms on how SIRT1 regulates m A modification to induce hepatocarcinogenesis remain unclear. Approach Results Here we demonstrate that exerts an oncogenic role by down‐regulating fat mass...
Long non-coding RNAs (lncRNAs) are dysregulated in various cancers. However, the clinical relevance and functional roles of AFAP1-AS1 colon cancer (CC) have not been clarified. We analyzed lncRNA expression patterns Gene Expression Omnibus (GEO) datasets Cancer Genome Atlas (TCGA) RNA-seq datasets, found that level was significantly elevated CC tissues. High levels were associated with poor disease-free survival overall patients. In vitro experiments demonstrated knockdown inhibited cell...
// Xiaoying Zhou 1, 2, * , Han Chen Li Zhu 3, Bo Hao 1 Weifeng Zhang Jie Hua Huiyuan Gu 4 Wujuan Jin 2 Guoxin Department of Gastroenterology, First Affiliated Hospital Nanjing Medical University, Nanjing, China Clinical College 3 People's Jingjiang, Taizhou, Soochow Suzhou, These authors contributed equally to this work Correspondence to: Zhang, email: guoxinz@njmu.edu.cn Keywords: helicobacter pylori infection, lncRNA, gastric cancer, MUC2 Received: April 27, 2016 Accepted: October 10,...
Purpose: Regulated in development and DNA damage response-1 (REDD1) is a stress-related protein involved the progression of cancer. The role regulatory mechanism REDD1 bladder urothelial carcinoma (BUC), however, yet unidentified.Experimental Design: expression BUC was detected by Western blot analysis immunohistochemistry (IHC). correlation between clinical features patients with were assessed. effects on cellular proliferation, apoptosis, autophagy, paclitaxel sensitivity determined both...
RNA interference (RNAi) technology can specifically silence the expression of a target gene and has emerged as promising therapeutic method to treat cancer. In present study, we showed that natural halloysite nanotube (HNT)-assisted delivery an active small interfering (siRNA) targeting receptor-interacting protein kinase 4 ( RIPK4 ) efficiently silenced its bladder The HNTs/siRNA complex increased serum stability siRNA, circulation lifetime in blood, promoted cellular uptake tumor...
Abstract Objective The objective of this survey was to study the association between Helicobacter pylori infection and severity coronary atherosclerosis. Methods population consisted 961 consecutive patients (711 males 250 females) who underwent angiography for suspected or known patients' body mass index, blood pressure, lipid, glucose, leukocyte count (10 9 /L), neutrophil -specific IgG antibodies were performed. Coronary angiograms scored according vessel score Gensini's score. Results A...
Metastasis is the major cause of cancer-related death in patients with gastric cancer, and aberrant expression various microRNAs (miRNAs) associated cancer metastasis. Profiling differentially expressed miRNAs was performed three cases primary corresponding metastatic lymph node tissues. Then, five most altered were further verified 16 paired samples. Two these assessed for their effects on regulation cell growth invasion. The miRNA profile data showed 151 upregulated (≥ 1.5-fold) 285...
AIM:To investigate whether hypoxia inducible factor (HIF)-1α modulates vasculogenic mimicry (VM) by upregulating VE-cadherin expression in esophageal squamous cell carcinoma (ESCC). METHODS: Esophageal cancer linesEca109 and TE13 were transfected with plasmids harboring small interfering RNAs targeting HIF-1α or VEcadherin.The proliferation invasion of cells detected MTT Transwell migration assays.The formation tubular networks was analyzed 3D culture vitro .BALB/c nude mice used to observe...
Constitutively activated nuclear factor kappa B (NF-κB) signalling plays vital roles in bladder urothelial carcinoma (BC) progression. We investigate the effect of receptor-interacting protein kinase 4 (RIPK4) on NF-κB activation and BC The expression RIPK4 was examined 25 cryopreserved paired samples 112 paraffin specimens. In vivo vitro assays were performed to validate pathway-mediated High observed tissues an independent predictor for poor overall survival. Up or downregulating enhanced...
Abstract Long noncoding RNAs (lncRNAs) play a crucial role in progression of bladder urothelial carcinoma (BUC). However, the molecular mechanisms behind this have not been elucidated yet. Here, we found that lncRNA MAFG‐AS1 , which is highly expressed BUC, correlated with aggressive characteristics and poor prognosis BUC. We demonstrate can promote BUC proliferation, invasion, metastasis, epithelial‐mesenchymal transition vitro vivo. Mechanistically, direct binding to Hu antigen R (HuR)...
Abstract Chemotherapeutic drugs will affect the process of spermatogenesis. However, most current studies on effects chemotherapeutic spermatogenesis are based mouse models, with a shortage human body evidence. In addition, mechanism causing disorder is not clear. Therefore, we have collected testicular tissues an inguinal-lipoma patient whose testes were resected after chemotherapy and who had normal underwent single-nucleus RNA sequencing (snRNA-Seq). After quality control, obtained total...
Abstract Recent studies have shown that shorter periods of ejaculatory abstinence may enhance certain sperm parameters, but the molecular mechanisms underlying these improvements are still unclear. This study explored whether reduced could improve semen quality, particularly for use in assisted reproductive technologies (ART). We analyzed samples from men with normal counts ( n = 101) and those low motility or concentration 53) after 3–7 days then 1–3 h abstinence, obtained Reproductive...
Through bioinformatics analysis, a novel lncRNA, LINC00460, was implicated in the development of multiple cancers.However, precise expression pattern, clinical significance and biological function LINC00460 colorectal cancer (CRC) remain unknown.Network databases were used to investigate correlation between CRC.In situ hybridization performed verify pattern CRC tissue microarray, which included 92 pairs adjacent normal tissues.The effect on proliferation evaluated by MTT, colony formation...
Long non-coding RNAs (LncRNAs) have been associated with several types of cancer. However, little is known about their role in lung adenocarcinoma (LUAD).LINC00968 was significantly differentially expressed LUAD tissues. Downregulated LINC00968 clinicopathological features LUAD. inhibited cell growth and metastasis by regulating the Hippo signaling pathway We demonstrated that acts as a ceRNA to consume miR-21-5p, enhancing accumulation SMAD7, miR-21-5p target.LINC00968 limits progression...
Abstract Long noncoding RNAs (lncRNAs) are involved in various physiological and pathological processes. However, the role of lncRNAs testicular germ cell tumor (TGCT) has been rarely reported. Our purpose is to comprehensively survey expression function TGCT. In this study, we used RNA sequencing construct lncRNA profiles 13 TGCT tissues 4 paraneoplastic explore The bioinformatics analysis showed that many differentially expressed GO KEGG enrichment analyses revealed participated biological...