A5103116317- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cardiac Imaging and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Heart Failure Treatment and Management
- Epigenetics and DNA Methylation
- Cardiac tumors and thrombi
- Diabetes Treatment and Management
- Carbohydrate Chemistry and Synthesis
- Potassium and Related Disorders
- ECG Monitoring and Analysis
- Angiogenesis and VEGF in Cancer
- Fibroblast Growth Factor Research
- Aortic Thrombus and Embolism
- Biomarkers in Disease Mechanisms
- Tuberculosis Research and Epidemiology
- Advanced Power Generation Technologies
- Health Systems, Economic Evaluations, Quality of Life
- Phagocytosis and Immune Regulation
- Biochemical and Molecular Research
Southwest Jiaotong University
2023-2024
Chengdu Third People's Hospital
2021-2024
RELX Group (United States)
2023
Zhongshan Hospital
2020-2022
Fudan University
2020-2022
Xian Yang Central Hospital
2020-2022
The First People’s Hospital of Lianyungang
2020-2022
The First Affiliated Hospital, Sun Yat-sen University
2020
Sun Yat-sen University
2020
Dalian Medical University
2019
AIM:To investigate whether hypoxia inducible factor (HIF)-1α modulates vasculogenic mimicry (VM) by upregulating VE-cadherin expression in esophageal squamous cell carcinoma (ESCC). METHODS: Esophageal cancer linesEca109 and TE13 were transfected with plasmids harboring small interfering RNAs targeting HIF-1α or VEcadherin.The proliferation invasion of cells detected MTT Transwell migration assays.The formation tubular networks was analyzed 3D culture vitro .BALB/c nude mice used to observe...
Atrial fibrillation (AF) is acknowledged as a disease continuum. Despite catheter ablation being recommended primary therapy for AF, the high recurrence rates have tempered initial enthusiasm. Insulin resistance (IR) has been established an independent predictor onset of AF. However, correlation between non-insulin-based IR indices and late AF in patients undergoing radiofrequency remains unknown.
LOXL1-AS1 is a long non-coding RNA (lncRNA) that plays crucial roles in various cancers. However, the functional role of laryngocarcinoma remains unclear. Thus we planned to probe into function and underlying mechanism laryngocarcinoma.Gene expression was evaluated cells using RT-qPCR. The ability cell proliferation migration assessed by CCK8, colony formation, wound healing transwell assays. interaction among LOXL1-AS1, miR-589-5p TRAF6 detected Ago2-RIP, pull down luciferase reporter...
AIM:To investigate the influence of phosphatidylinositol-3-kinase protein kinase B (PI3K/AKT)-HIF-1α signaling pathway on glycolysis in esophageal carcinoma cells under hypoxia. METHODS:Esophageal cell lines Eca109 and TE13 were cultured hypoxia environment, protein, mRNA activity levels inducible factor-1 alpha (HIF-1α), glucose transporter 1, hexokinase-Ⅱ, phosphofructokinase 2 lactate dehydrogenase-A determined.Supernatant lactic acid concentrations also detected.The PI3K/AKT was then...
Nasopharyngeal carcinoma (NPC) is a malignant tumor in the nasopharyngeal cavity. LncRNA PTPRG-AS1 essential NPC radiosensitivity. This study sought to explore mechanism of radiosensitivity by regulating miR-124-3p/LHX2 axis. First, NPC-related microarray was analyzed screen differentially expressed lncRNAs. and miR-124-3p expression patterns tissues adjacent patients cell lines were detected RT-qPCR. knocked down CNE2 5-8 F cells transfection. The radiosensitivity, proliferation apoptosis...
Background: Pancreatic stellate cells (PSCs) are precursor of cancer-associated fibroblasts that promote tumor proliferation, invasion, and metastasis. The glucagon-like peptide-1 receptor agonist exendin-4 has been reported to exhibit anticancer effects against several cells; however, the function mechanism underlying on pancreatic cancer remain unclear. Methods: Gene expression levels were determined using quantitative real-time polymerase chain reaction (qRT-PCR) Western blot assay. Cell...
<title>Abstract</title> <bold>Aims: </bold>To investigate the association between insulin resistance (IR), left atrial enlargement, and fibrillation (AF) recurrence in AF patients undergoing radiofrequency catheter ablation (RFCA). <bold>Methods: </bold>910 were evaluated for IR using TyG-BMI enlargement LAD. Various analytical methods employed to study relationship TyG-BMI, LAD, recurrence. <bold>Results: </bold>Over a median 12-month follow-up period, 189 (20.77%) cases of observed. The...
There is limited available data regarding the impact of cycle length (CL) prolongation when converting atrial fibrillation (AF) to organized tachycardia (AT) and its effect on clinical outcomes.
Pulsed field ablation (PFA), a nonthermal ablative mechanism, has been proven to be effective and safe in clinical application. To date, PFA used for only atrial fibrillation (AF) limited trials. The present study describes case of paroxysmal AF which mitral cavotricuspid isthmus (CTI)-dependent flutter was discovered incidentally during operation successfully ablated with PFA. This is the first medical record combined CTI flutter. report revealed that can independently treat complex...
Objective To investigate the risk factors for prognosis of severe acute pancreatitis (SAP). Methods The clinical data 563 patients with (AP) treated from January 2008 to December 2014 were analyzed retrospectively. There 334 mild (MAP), and 198 moderately (MSAP), 31 (SAP). Risk associated MAP MSAP+ SAP group, MSAP group determined by univariate logistic regression, multivariate analysis was used determine severity AP. Results Univariate regression showed that age, WBC, serum...
Abstract Pulsed field ablation(PFA) as an nonthermal ablative mechanism is proved to be effective and safe in clinical application. Up now, PFA only used for atrial fibrillation ablation limited trials. This article describes a case of paroxysmal which mitral carvotricuspid isthmus dependented flutter was discovered incidentally during operation successfully ablated with PFA. the first medical record combined flutter, marking promise treatment other various kind arrhythmia, including related...
Objective To investigate the changes of hypoxia-inducible factor(HIF)-1α and hexokinase-Ⅱ(HK-Ⅱ)expression in human esophageal squamous cell carcinoma its effect glycolysis.Methods TE13 cells Eca109 were cultured under hypoxic condition(1 ％O2)for different time(6,12,24 48 hours).Cells normal oxygen condition(20％O2)were set as control.The HIF-1α HK-Ⅱ expressions at protein level detected by Western blot.HIF-1α genes specifically silenced with RNA interference technology(RNAi),and then...
Background: The effect of catheter ablation (CA) versus drug therapy on cardiac function improvement is not clear for patients with persistent atrial fibrillation and heart failure. To compare the short-term therapeutic effects between CA conventional therapy, we conducted a meta-analysis current randomized controlled trials (RCTs). Objective method: analyses systematically collected PubMed, Embase, Cochrane Library RCTs comparing medical in In order to reduce impact other factors function,...
With the rapid progress of novel technology, detection rate coronary artery calcification has increased year by year. Coronary is generally considered to be a natural progression atherosclerosis and common in patients with atherosclerotic disease, chronic kidney diabetes. However, in-depth study its pathogenesis, people have new understanding calcification. Key words: Coronary calcification; Endothelial injury; Progress
Introduction: Patients with atrial fibrillation excluded left appendage(LAA) thrombosis is typically performed utilizing transesophageal echocardiography (TEE).Intracardiac (ICE) can be a suitable alternative to detect thrombosis. Methods: We searched PubMed ,Cochrane Library and Embase for published abstracts manuscripts until June1, 2020. Studies reporting clinical outcomes comparing TEE vs. ICE LAA in human subjects aged ≥ 18 years were included. Two investigators independently extracted...
Abstract Introduction: Left atrial appendage (LAA) thrombus in patients with fibrillation is usually detected by transesophageal echocardiography (TEE). Intracardiac (ICE) can be a suitable alternative to detect thrombosis. We performed meta-analysis of all studies that compared ICE vs. TEE for LAA Methods: searched PubMed, Cochrane Library, and Embase published abstracts manuscripts until June 1, 2020. Studies reporting clinical outcomes comparing human subjects aged ≥ 18 years were...