A5018748052- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Biliary and Gastrointestinal Fistulas
- Colorectal Cancer Screening and Detection
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastroesophageal reflux and treatments
- Dysphagia Assessment and Management
- Cancer-related gene regulation
- Circular RNAs in diseases
- NF-κB Signaling Pathways
- Advanced Biosensing Techniques and Applications
- RNA regulation and disease
- Fibroblast Growth Factor Research
Zhongda Hospital Southeast University
2017-2025
Changchun University of Chinese Medicine
2024
Zhejiang University
2024
Changshu No.1 People's Hospital
2023
Jiangsu University
2022
Jintan People's Hospital
2022
Xuzhou No.1 People's Hospital
2022
Xuzhou Medical College
2022
Nanjing Medical University
2010-2018
Jiangsu Province Hospital
2010-2018
Colorectal cancer ( CRC ) is the third most commonly diagnosed in both men and women USA. However, underlying molecular mechanisms that drive tumorigenesis are still not clear. Several studies have reported long noncoding RNA s (lnc s) important roles tumor development. Here, we undertook a transcriptome microarray analysis 6 pairs of tissues their corresponding adjacent normal tissues. A total 1705 differentially expressed lnc were detected at stages I/ II III / IV (fold change greater than...
Dysregulation of microRNAs (miRNAs) is associated with a variety diseases, including Crohn's disease (CD), but the essential biological functions and crucial targets miRNAs remain largely unknown. The present study investigated aberrant colonic mucosal in active CD patients. miRNA levels were assayed inflamed colon patients by quantitative real-time polymerase chain reaction. influence differential expressed miR-124 on its putative target, aryl hydrocarbon receptor (AHR), was patients,...
Abstract Background Numerous studies have revealed that long noncoding RNAs (lncRNAs) are closely related to the development of many diseases and carcinogenesis. However, their specific biological function molecular mechanism in oesophageal squamous cell carcinoma (ESCC) remains unclear. Methods RNA-Seq was performed determine differential expressions lncRNAs ESCC, level SNHG16 expression detected ESCC intraepithelial neoplasia (IEN) samples. In vitro vivo experiments were explore role...
This study retrospectively reviewed 48 cases of gastric submucosal tumors (SMTs) treated by endolumenal endoscopic full-thickness resection (EFR) microsurgery in our gastrointestinal endoscopy center.From November 2009 to October 2012, underwent EFR for muscularis propria-originating SMTs. Characteristics the patients, clinical efficacy, safety EFR, and post-EFR pathological diagnoses were evaluated retrospectively.EFR was successfully performed with 52 lesions. The median operation time...
AIM:To investigate the biological role of miR-1290 in esophageal squamous cell carcinoma (ESCC) progression and invasion underlying mechanism. METHODS:Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to evaluate expression ESCC tissue samples.The roles proliferation, migration were identified using mimic-transfected cells.In addition, regulatory effect on suppressor cancer (SCAI) evaluated qRT-PCR, Western blot analysis a dual luciferase reporter assay.RESULTS:...
High mobility group box 1 (HMGB1) protein has been previously detected in the inflammatory microenvironment of bone fractures. It is well known that HMGB1 acts as a chemoattractant to mesenchymal stem cells (MSCs). In present study, effects on cytokine secretion from MSCs were determined, and molecular mechanisms underlying these osteogenic differentiation elucidated. To detect secretion, antibody array assays performed, which demonstrated HGMB1 induced differential cytokines are...
Background The aim of this study was to verify the safety and efficacy endoscopic resection (ER) for gastric gastrointestinal stromal tumors (GISTs).
ABSTRACT Objective To investigate the feasibility and accuracy of esophageal sponge cytology in screening squamous cell carcinoma (ESCC). Methods From May 2021 to June 2022, an opportunistic was performed people aged 40–75 from a high‐risk region for ESCC. Using collector that independently developed China cytology, positive determined as detection atypical cells or more severe lesions. The safety, tolerability, were compared with those pathological examination after endoscopy biopsy....
SRY-box 9 (SOX9) is overexpressed in a number of human tumors, including gastric cancer (GC). However, the function SOX9 development GC remains unknown. In present study, activated Hippo-yes-associated protein (YAP) signaling pathway to enhance epithelial-mesenchymal transition cell lines. The results suggested that knockdown inhibited invasion, proliferation and migration cells. Furthermore, silencing upregulated expression E-cadherin, an epithelial marker, downregulated mesenchymal...
INTRODUCTION: Screening is the pivotal strategy to relieve burden of esophageal squamous cell carcinoma (ESCC) in high-risk areas. The cost, invasiveness, and accessibility esophagogastroduodenoscopy (EGD) necessitate development preliminary screening methods. METHODS: Residents aged 40–85 years were recruited a area ESCC. Esophageal cells collected using an approved novel capsule sponge, cytology slides scanned by trained artificial intelligence (AI) system before cytologists provided...
BACKGROUND During emergency endoscopic retrograde cholangiopancreatography (ERCP), the safety and feasibility of performing one-stage treatment for patients with acute cholangitis (AC) due to choledocholithiasis are unclear. AIM To investigate moderate severe AC. METHODS We enrolled all diagnosed common bile duct stones from January 2019 July 2023. The outcomes were compared in this study between who underwent ERCP within 24 h those later, employing a propensity score (PS) framework. Our...
AIM:To investigate the influence of phosphatidylinositol-3-kinase protein kinase B (PI3K/AKT)-HIF-1α signaling pathway on glycolysis in esophageal carcinoma cells under hypoxia. METHODS:Esophageal cell lines Eca109 and TE13 were cultured hypoxia environment, protein, mRNA activity levels inducible factor-1 alpha (HIF-1α), glucose transporter 1, hexokinase-Ⅱ, phosphofructokinase 2 lactate dehydrogenase-A determined.Supernatant lactic acid concentrations also detected.The PI3K/AKT was then...
Background Chronic hepatitis B virus (HBV) infection is a leading cause of liver morbidity and mortality worldwide. Liver fibrosis resulting from viral infection-associated inflammation direct damage plays an important role in disease management prognostication. The mechanisms underlying the contribution microenvironment to HBV patients are not fully understood. There absence effective clinical treatments for progression; thus, establishing suitable vitro order design novel therapeutics...
HIF-1α (hypoxia-inducible factor 1 alpha) is believed to promote oesophageal squamous tumour growth. Thus, an inhibitor viewed as a therapeutic target in treating cancer. Recently, YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole] has been widely used potential and being developed novel anticancer drug. However, little known about the effects of human In present study, we aimed investigate these esophageal cancer cell line; i.e. Eca109 cells. We found that abolished hypoxia-induced...
Hypoxia inducible factor 1α (HIF-1α) is highly expressed and implicated in the progression of esophageal squamous cell carcinoma. To investigate potential mechanism by which HIF-1α contributes to carcinoma, here we established stable carcinoma lines Eca-109 TE- 13 was depleted shRNA mediated gene silencing. In additon, used specific inhibitor YC-1 inhibit expression. Our vitro studies demonstrated that or chemical inhibition led reduced proliferation increased apoptosis cells, as well...
Abstract The role and mechanism of insulin‐like growth factor‐2 mRNA‐binding protein 3 (IGF2BP3) in the metastasis esophageal squamous cell carcinoma (ESCC) remain unclear. In this study, IGF2BP3 mRNA expression levels were evaluated ESCC tissues. Small interfering RNAs (siRNAs), plasmid overexpression, stable lentivirus transfection used to manipulate intracellular levels. tumorigenesis was investigated vitro vivo. target transcripts detected, acetylation effect ratios promoter region by...
The use of artificial intelligence (AI) assisted white light imaging (WLI) detection systems for superficial esophageal squamous cell carcinoma (SESCC) is limited by training with images from one specific endoscopy platform.In this study, we developed an AI system a convolutional neural network (CNN) model using WLI Olympus and Fujifilm platforms. dataset consisted 5892 1283 patients, the validation included 4529 1224 patients. We assessed diagnostic performance compared it that...