A5101493838- Berberine and alkaloids research
- Bone fractures and treatments
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Electrocatalysts for Energy Conversion
- Liver Disease Diagnosis and Treatment
- Mast cells and histamine
- Gut microbiota and health
- Orthopedic Surgery and Rehabilitation
- Alkaloids: synthesis and pharmacology
- Liver physiology and pathology
- Cannabis and Cannabinoid Research
- Electrochemical Analysis and Applications
- Parkinson's Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Reconstructive Surgery and Microvascular Techniques
- Ga2O3 and related materials
- Stroke Rehabilitation and Recovery
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Superconductivity in MgB2 and Alloys
- Traditional Chinese Medicine Analysis
- Phytochemistry and biological activities of Ficus species
- Advanced machining processes and optimization
- TGF-β signaling in diseases
Chinese Academy of Sciences
2018-2025
University of Hong Kong
2025
Changchun Institute of Optics, Fine Mechanics and Physics
2025
University of Chinese Academy of Sciences
2025
Qilu Hospital of Shandong University
2025
Xi'an Jiaotong University
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2022-2025
Nanyang Normal University
2023-2024
Anhui University
2022-2024
Southwest University of Science and Technology
2023
Abstract The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In this process, tyrosine hydroxylase (TH) is rate-limiting enzyme that hydroxylates and generates levodopa ( l -dopa) with tetrahydrobiopterin (BH 4 ) as a coenzyme. Here, we show oral berberine (BBR) might supply H • through dihydroberberine (reduced BBR produced by bacterial nitroreductase) promote production of BH from dihydrobiopterin; increased enhances TH activity, which accelerates -dopa gut...
The progression of hyperuricemia disease is often accompanied by damage to renal function. However, there are few studies on nephropathy, especially its association with intestinal flora. This study combines metabolomics and gut microbiota diversity analysis explore metabolic changes using a rat model as well the in flora composition. results showed that amino acid metabolism was disturbed serine, glutamate glutamine being downregulated whilst glycine, hydroxyproline alanine upregulated....
Abstract Trimethylamine- N -oxide (TMAO) derived from the gut microbiota is an atherogenic metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO production in and treat atherosclerosis. Effects of BBR on microbiota, as well plaque development atherosclerosis were investigated culture animal intestinal bacterial, HFD-fed animals atherosclerotic patients, respectively. We found that oral lowers biosynthesis intestine through interacting with enzyme/co-enzyme...
Background and Aims: Liver fibrosis is a leading indicator for increased mortality long-term comorbidity in NASH. Activation of HSCs excessive extracellular matrix production are the hallmarks liver fibrogenesis. Tyrosine kinase receptor (TrkB) multifunctional that participates neurodegenerative disorders. However, paucity literature available about TrkB function fibrosis. Herein, regulatory network therapeutic potential were explored progression hepatic Methods Results: The protein level...
Berberine (BBR) is an isoquinoline alkaloid extracted from Coptis chinensis that improves diabetes, hyperlipidemia and inflammation. Due to the low oral bioavailability of BBR, its mechanism action closely related gut microbiota. This study focused on CYP51 enzyme intestinal bacteria elucidate a new BBR transformation by demethylation in microbiota through multiple analytical techniques. First, docking was performed; then, pharmacokinetics determined ICR mice vivo, metabolism liver, kidney,...
Purpose We aimed to investigate the correlation between CT-derived fractional flow reserve (CTFFR) and myocardial strain in patients with single coronary artery stenosis diagnostic value of CTFFR identifying impaired strain. Methods selected 89 patients, categorized into three groups based on affected artery: 36 left anterior descending (LAD), 23 circumflex (LCX), 30 right (RCA) stenosis, along 25 healthy controls. investigated correlations both global regional parameters. Additionally, we...
The Stressed Mirror Polishing method (SMP) enables the high-quality and efficient fabrication of short-focus off-axis aspheres (SFOA) for overcoming difficulties arising from large asphericity, which makes polishing tool unfitted mirror surface shape produces mid- high-frequency errors. However, there remains a lack precise iterative loading methods detailed analyses loaded stability processing SFOA through SMP. Therefore, foundational analysis model SMP was established, integrating...
Introduction: Parkinson’s disease (PD) is the second most common neurodegenerative disorder, without any widely available curative therapy. Metabolomics a powerful tool which can be used to identify unexpected pathway-related progression and pathophysiological mechanisms. In this study, metabolomics in brain, plasma liver was investigated an experimental PD model, discover small molecules that are associated with dopaminergic cell loss. Methods: Sprague Dawley (SD) rats were injected...
Rationale:The efficacy and mechanism of hydroxyurea in the treatment atherosclerosis have rarely been reported.The goal this study was to investigate high-fat diet-fed ApoE -/-mice against examine possible underlying outcomes.Methods: were fed a diet for 1 month then administered by gavage continuously 2 months.Aortic root hematoxylin-eosin (H&E) staining oil red O used verify hydroxyurea; biochemical methods ELISA detect changes relevant metabolites serum.16S rRNA composition intestinal...
Abstract Background This study aims to assess and compare the functional outcomes of patients with acute ischemic stroke (AIS) eligible for tissue plasminogen activator (t‐PA) treatment who received care from either a fifth‐generation(5G) mobile unit (MSU) or traditional emergency medical service (EMS). Method The recruited between February 2020 January 2022, final 90‐day follow‐up concluded in April 2022. Prior enrollment, were assigned EMS MSU based on predetermined rules. primary outcome...
Background Chronic hepatitis B virus (HBV) infection is a leading cause of liver morbidity and mortality worldwide. Liver fibrosis resulting from viral infection-associated inflammation direct damage plays an important role in disease management prognostication. The mechanisms underlying the contribution microenvironment to HBV patients are not fully understood. There absence effective clinical treatments for progression; thus, establishing suitable vitro order design novel therapeutics...
In spite of advances in antibiotics, urinary tract infection (UTI) is still among the most common reasons for antibiotic medication worldwide. Persicaria capitata (Buch.-Ham. ex D. Don) H.Gross (P. capitata) a herbal medicine used by Miao people China to treat UTI. However studies its mechanism are challenging, owing complexity P. with multiple constituents acting on metabolic pathways.The objective this study was explore working infection.Relinqing® granule, which solely made from aqueous...
A series of novel 4-phenoxyquinoline derivatives containing the benzo[d]thiazole-2-yl urea moiety were synthesized and evaluated for their cytotoxicity against HT-29, MKN-45, H460 cell lines. The structures target compounds confirmed by (1) H NMR MS spectra. Most them showed moderate to excellent potency three tested Especially, compound 23 was identified a promising agent (c-Met IC50 = 17.6 nM), showing most potent anticancer activities with values 0.18, 0.06, 0.01 µM lines, respectively....
Aims The aim of this study was to describe the technique distraction osteogenesis followed by arthrodesis using internal fixation manage complex conditions ankle, and present results technique. Patients Methods Between 2008 2014, performed in 12 patients with ankle due trauma or infection. There were eight men four women: their mean age 35 years (23 51) at time surgery. Bone healing functional recovery evaluated according criteria described Paley. Function assessed ankle-hindfoot scale...