A5003755370- Bone health and treatments
- Advanced Surface Polishing Techniques
- Cancer Treatment and Pharmacology
- Optical Systems and Laser Technology
- Radiopharmaceutical Chemistry and Applications
- Adaptive optics and wavefront sensing
- PARP inhibition in cancer therapy
- Advanced Measurement and Metrology Techniques
- Laser Material Processing Techniques
- Photonic and Optical Devices
- Cancer, Hypoxia, and Metabolism
- Optical measurement and interference techniques
- Engineering Applied Research
- DNA Repair Mechanisms
- Advanced machining processes and optimization
- Semiconductor Lasers and Optical Devices
- CRISPR and Genetic Engineering
- Optical Coatings and Gratings
- Millimeter-Wave Propagation and Modeling
- Industrial Vision Systems and Defect Detection
- Advanced optical system design
- Microwave Engineering and Waveguides
- Low-power high-performance VLSI design
- Calibration and Measurement Techniques
- Cancer Immunotherapy and Biomarkers
Changchun Institute of Optics, Fine Mechanics and Physics
2014-2025
Chinese Academy of Sciences
2017-2025
Murdoch University
2024
Tsinghua University
2016-2023
Beijing University of Posts and Telecommunications
2023
State Key Laboratory of Information Photonics and Optical Communications
2023
Tianjin University
2023
Shaanxi Provincial People's Hospital
2010-2021
Jilin University
2018-2019
Sun Yat-sen University
2019
Immune checkpoint blockade (ICB) has demonstrated curative potential in several types of cancer, but only for a small number patients. Thus, the identification reliable and noninvasive biomarkers predicting ICB responsiveness is an urgent unmet need. Here, we show that increased tumor vessel perfusion treatment-sensitive EO771 MMTV-PyVT breast as well CT26 MCA38 colon models, not treatment-resistant MCaP0008 4T1 models. In sensitive ability anti–cytotoxic T lymphocyte–associated protein 4 or...
The Stressed Mirror Polishing method (SMP) enables the high-quality and efficient fabrication of short-focus off-axis aspheres (SFOA) for overcoming difficulties arising from large asphericity, which makes polishing tool unfitted mirror surface shape produces mid- high-frequency errors. However, there remains a lack precise iterative loading methods detailed analyses loaded stability processing SFOA through SMP. Therefore, foundational analysis model SMP was established, integrating...
Abstract The majority of patients with late-stage breast cancer develop distal bone metastases. microenvironment can affect response to therapy, and uncovering the underlying mechanisms could help identify improved strategies for treating metastatic cancer. Here, we observed that osteoclasts reduced sensitivity cells DNA damaging agents, including cisplatin PARP inhibitor (PARPi) olaparib. Metabolic profiling identified elevated glutamine production by osteoclasts. Glutamine supplementation...
Lysyl oxidase‑like 2 (LOXL2), a member of the lysyl oxidase gene family, is involved in progression hepatocellular carcinoma and metastasis. Increased expression LOXL2 has been identified several types cancer, including carcinoma. Recently, reported to promote epithelial‑mesenchymal transition by reducing E‑cadherin via upregulation Snail expression. The present study provided evidence demonstrating that inhibited fructose‑1, 6‑biphosphatase (FBP1) enhanced glycolysis Huh7 Hep3B cell lines...
We propose a new technique to fabricate highly specialized optical element, hybrid planar Grating/Fresnel lens (G-Fresnel), which is particularly useful improve or enable more-affordable miniature/portable spectrometers. Both the Fresnel and grating surface are fabricated simultaneously by sandwiching soft PDMS between hard pre-replicated negative surface. Several adhesion reduction techniques also investigated that help both fabrication cost efficiency (by reducing solidification time) as...
No physical model of stressed mirror polishing, based on the small deflection and deformation elastic thin plates, has been applied in processing lightweight mirrors. We propose an equivalent thin-plate method for loading mirrors first time. Stressed polishing aspheric are simulated using small-deflection theory plate. simulate off-axis silicon carbide (SiC) with three different structures, determining corresponding thickness plate a structure nearly uniform surface density distribution...
On-machine measurements can improve the form accuracy of optical surfaces in single-point diamond turning applications; however, commercially available linear variable differential transformer sensors are inaccurate and potentially scratch surface. We present an on-machine measurement system based on capacitive displacement for high-precision surfaces. In proposed system, a position-trigger method was developed to ensure strict correspondence between points data with no intervening...
In order to improve the fabrication efficiency and testing accuracy of meter-scale, large monolithic mirrors, hydraulic support units (HSUs) are commonly used. However, challenges reduce disparity HSUs' stiffness keep stability mirrors' altitude hard resolve, especially for large-scale mirrors. this paper, we found air ratio working fluid HSUs is a key factor designing resolve from analytical solution that derived supporting Here designed, tested fabricated dozens used four-meter SiC mirror,...
A vapor-deposited GaS passivating layer is formed on GaAs(100) with α-Ga2S3 powder used as a single-source precursor for the deposition. The films grown show near-single-crystal quality, and are characterized by Auger electron spectroscopy x-ray diffraction spectroscopy. band-edge discontinuities of GaS/GaAs heterojunction determined to be 1.9 eV valence band 0.3 conduction band, respectively, ultraviolet photoelectron electron-energy-loss It also observed that valence-band structure...
A rigid conformal (RC) lap can smooth mid-spatial-frequency (MSF) errors, which are naturally smaller than the tool size, while still removing large-scale errors in a short time. However, RC-lap smoothing efficiency performance is poorer expected, and existing models cannot explicitly specify methods to improve this efficiency. We presented an explicit time-dependent evaluation model that contained specific parameters directly derived from parametric Preston equation. Based on model, we...
In this study, the stressed mirror polishing technique is used to perform off-axis aspheric silicon carbide (SiC) full-aperture for first time. Mechanical and optical parameter analysis methods have been proposed. A medium-diameter SiC thin-plate as a scaling model an system mirror. full diameter simulation was completed, conceptual design stress loading equipment presented. An initial surface method of mirror, providing reference rapid mirrors, also
Thirty Meter Telescope's Tertiary Mirror Cell Assembly (TMTM3-CA) will be manufactured in Changchun Institute of Optics, Fine Mechanics and Physics (CIOMP). To reduce the risk fabricating TMTM3, a prototype made Zerodur with d/t ratio 72 is planned to polished. Here focus on design scheme prototype's optical manufacturing support system. Firstly number points was estimated, then structural for equal-force polishing system are drawn, finally layout optimization carried out. As its high...
Abstract Background Pericardial devascularization (PCDV) and portosystemic shunt were reported to have favorable results for the management of portal hypertension in cirrhotic patients China West, respectively. This study was undertaken investigate effects a modified proximal splenocaval plus PCDV on variceal bleeding with hypertension. Methods From January 1997 December 2007, 168 origin received an operation gastroesophageal bleeding. Of these, 90 procedure (Combined Group) other 78 only...
The Giant Steerable Science Mirror (GSSM) is the tertiary mirror system of Thirty Meter Telescope (TMT) that relays optical beams from secondary to active instruments on Nasmyth platforms. One key technologies involved in GSSM functions error budget allocation engineering TMT. A novel approach analysis and with strong adaptability, which based normalized Point Source Sensitivity (PSSn), proposed. relay function including quality wavefront, rationality mechanism, stability light were achieved...
When fabricating ultra-large aperture mirrors, it's always very crucial to reduce the control difficulty and lower cost of support system while providing accuracy required for on-line fabrication testing. For this purpose, layout optimization method supporting points equal-force is proposed. Firstly through surface fitting, figure supported mirror analyzed, objectives are auto-updated. Afterward optimization, whose model has capability adaptive finite element analysis, arbitrary-shaped thin...
M3M (Mirror 3 Mirror) of TMT (Thirty Meter Telescope) project is a 3.5m×2.5m×0.1m solid flat elliptical mirror. M3MP 1/4 prototype serving as pathfinder for M3M. Fabrication and testing were carried out based on planned sketch established in the past 2 years. Technology including polishing strategy, site vertical Fizeau sub-aperture interfere test, scanning pentaprism system dual-supporting tested fabrication M3MP. This paper give brief introduction work some results.
Oat grain is a traditional human food rich in dietary fiber that contributes to improved health. Interest the crop has surged recent years owing its use as basis for plant-based milk analogs. an allohexaploid with large, repeat-rich genome was shaped by subgenome exchanges over evolutionary timescales. In contrast many other cereal species, genomic research oat still at early stage, and surveys of structural diversity gene expression variability are scarce. Here, we present annotated...
<p>Metabolomics of primary tumors vs bone metastasis</p>
<p>Supplementary Video S3 is related to Figure 5 (Zoledronate-only group).</p>
<div>Abstract<p>The majority of patients with late-stage breast cancer develop distal bone metastases. The microenvironment can affect response to therapy, and uncovering the underlying mechanisms could help identify improved strategies for treating metastatic cancer. Here, we observed that osteoclasts reduced sensitivity cells DNA damaging agents, including cisplatin PARP inhibitor (PARPi) olaparib. Metabolic profiling identified elevated glutamine production by osteoclasts....
<p>Metabolomics of macrophages vs osteaoclasts</p>
<p>Supplementary Video S3 is related to Figure 5 (Zoledronate-only group).</p>