A5075453290- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Nanoparticles: synthesis and applications
- Adaptive optics and wavefront sensing
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Nanoparticle-Based Drug Delivery
- Optical Systems and Laser Technology
- Carcinogens and Genotoxicity Assessment
- Advanced optical system design
- RNA modifications and cancer
- Air Quality and Health Impacts
- PI3K/AKT/mTOR signaling in cancer
- Gold and Silver Nanoparticles Synthesis and Applications
- Endoplasmic Reticulum Stress and Disease
- Heavy Metal Exposure and Toxicity
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Graphene and Nanomaterials Applications
- RNA and protein synthesis mechanisms
- Effects and risks of endocrine disrupting chemicals
- Viral Infectious Diseases and Gene Expression in Insects
- Telomeres, Telomerase, and Senescence
NSF’s NOIRLab
2023-2024
Seoul National University
2014-2023
KoreaBio
2022-2023
Optica
2009-2020
Kitt Peak National Observatory
2010-2019
Advanced Institute of Convergence Technology
2011-2017
Seoul National University of Science and Technology
2008-2017
Seoul Institute
2017
Kyung Hee University
2000-2017
Seoul National University Hospital
2017
The development of technology enables the reduction material size in science. use particle from micro to nanoscale not only provides benefits diverse scientific fields but also poses potential risks humans and environment. For successful application nanomaterials bioscience, it is essential understand biological fate toxicity nanoparticles. aim this study was evaluate distribution as well magnetic nanoparticles enable their applications life science, such drug development, protein detection,...
Targeting cancer: Multifunctional magnetic gold nanoshells (Mag-GNS) are prepared by coating silica spheres with embedded Fe3O4 nanoparticles. The nanoparticles allow resonance imaging (MRI) for diagnosis, and the enable photothermal therapy. By attaching an antibody to Mag-GNS a poly(ethylene glycol) (PEG) linker, cancer cells can be targeted. Supporting information this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z602471_s.pdf or from author. Please...
The subchronic inhalation toxicity of silver nanoparticles was studied in Sprague-Dawley rats. Eight-week-old rats, weighing approximately 253.2 g (males) and 162.6 (females), were divided into four groups (10 rats each group): fresh-air control, low dose (0.6 × 106 particle/cm3, 49 μg/m3), middle (1.4 133 high (3.0 515 μg/m3). animals exposed to (average diameter 18–19 nm) for 6 h/day, 5 days/week, 13 weeks a whole-body chamber. In addition mortality clinical observations, body weight, food...
Cells in motion: Multifunctional nanoparticles, with a unique combination of magnetic and fluorescent properties, coupled biocompatibility are prepared. The uptake the nanoparticles by cells is investigated, an external “magnetic motor effect” on containing observed (see scheme). Supporting information for this article available WWW under http://www.angewandte.org or from author. Please note: publisher not responsible content functionality any supporting supplied authors. Any queries (other...
Human SIRT1 controls various physiological responses including cell fate, stress, and aging, through deacetylation of its specific substrate protein. In processing DNA damage signaling, attenuates a cellular apoptotic response by p53 tumor suppressor. The present study shows that, upon exposure to radiation, could enhance repair capacity protein Ku70. Ectopically over-expressed resulted in the increase strand breakages produced radiation. On other hand, repression endogenous expression siRNA...
With the increased production and widespread use of multiwalled carbon nanotubes (MWCNTs), human environmental exposure to MWCNTs is inevitably increasing. Therefore, this study monitored possible MWCNT release in a nanotube research laboratory. To estimate potential researchers evaluate improvement workplace environment after implementation protective control measures, personal area monitoring were conducted an facility where handled unrefined materials. The number, composition, aspect...
Organic dye-incorporated smart silica-coated core–shell magnetic nanoparticles (MNP@SiO2) having dual-functionality (-PEG/NH2, see Figure) were easily fabricated, and the amine moieties on NP surface modified with maleimide functionality for specific covalent immobilization of biopolymers bioactive small molecules. The sequence-independent antibodies (Ab) is highlighted; Ab-modified MNP@SiO2 particles exhibit recognition floating tumor cells or target membrane adherent breast cancer cells.
We have developed biocompatible, photostable, and multiplexing-compatible surface-enhanced Raman spectroscopic tagging material (SERS dots) composed of silver nanoparticle-embedded silica spheres organic labels for cellular cancer targeting in living cells. SERS dots showed linear dependency signatures on their different amounts, allowing possibility the quantification targets. In addition, antibody-conjugated were successfully applied to HER2 CD10 membranes exhibited good specificity....
Biocompatible silica-overcoated magnetic nanoparticles containing an organic fluorescence dye, rhodamine B isothiocyanate (RITC), within a silica shell [50 nm size, MNP@SiO 2 (RITC)s] were synthesized.For future application of the (RITC)s into diverse areas research such as drug or gene delivery, bioimaging, and biosensors, detailed information cellular uptake process is essential.Thus, this study was performed to elucidate precise mechanism by which lung cancer cells nanoparticles.Lung...
〈n ␣-helical MA-3 domain appears in several translation initiation factors, including human eukaryotic factor 4G (eIF4G) and DAP-5/NAT1/p97, as well the tumor suppressor Pdcd4.The function of is, however, unknown.C-terminal eIF4G (eIG4Gc) contains an that is located within eIF4A-binding region, suggesting a role for eIF4A binding.Interestingly, C-terminal DAP-5/NAT1/p97 domain, but it does not bind to eIF4A.Mutation amino acid residues conserved between Pdcd4 eIF4Gc found indicates some...
In this study, surface-enhanced Raman spectroscopy (SERS)-encoded magnetic nanoparticles (NPs) are prepared and utilized as a multifunctional tagging material for cancer-cell targeting separation. First, silver-embedded NPs prepared, composed of an 18-nm core 16-nm-thick silica shell with silver formed on the surface. After simple aromatic compounds adsorbed NPs, they coated to provide them chemical physical stability. The resulting silica-encapsulated (M-SERS dots) produce strong SERS...
Reducing the particle size of materials is an efficient and reliable tool for improving bioavailability a gene or drug delivery system. In fact, nanotechnology helps in overcoming limitations can change outlook world regarding science. However, potential harmful effect nanomaterial on workers manufacturing nanoparticles expected workplace lack information body distribution inhaled may pose serious problem. this study, we addressed question by studying mice using approximately 50-nm...
Krebs im Visier: Multifunktionelle magnetische Gold-Nanoschalen (Mag-GNS) entstehen beim Beschichten von Siliciumoxid-Kugeln mit Gold-Nanoschalen, in die Fe3O4-Nanopartikel eingelagert sind. Die ermöglichen eine kernspintomographische Diagnose (MRI) und photothermische Therapie. Nach Anbinden eines Antikörpers an Mag-GNS über einen Polyethylenglycol(PEG)-Linker lassen sich Krebszellen gezielt ansteuern. Supporting information for this article is available on the WWW under...