A5070982963- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Ultrasound and Hyperthermia Applications
- Bone health and treatments
- Bone health and osteoporosis research
- Photoacoustic and Ultrasonic Imaging
- Calcium Carbonate Crystallization and Inhibition
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Ultrasound and Cavitation Phenomena
- Organic Light-Emitting Diodes Research
- Analytical Chemistry and Sensors
- Advanced Chemical Sensor Technologies
- Nanoparticles: synthesis and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Advanced Nanomaterials in Catalysis
- Parathyroid Disorders and Treatments
- Mesoporous Materials and Catalysis
- Silicone and Siloxane Chemistry
- Cancer Cells and Metastasis
- Folate and B Vitamins Research
- Nanoparticle-Based Drug Delivery
- Ultrasound Imaging and Elastography
Emory University
2012-2023
Seoul National University Bundang Hospital
2017-2020
Seoul National University
2009-2019
University of Minnesota
2019
Gyeonggi Research Institute
2018
University of Seoul
2014
We recently identified an engineered bioactive silica-based nanoparticle formulation (designated herein as NP1) that stimulates in vitro differentiation and mineralization of osteoblasts, the cells responsible for bone formation, increases mineral density young mice vivo. The results demonstrate these nanoparticles have intrinsic biological activity; however, intracellular fate a complete understanding mechanism(s) involved remains to be elucidated. Here we investigated cellular by which NP1...
A new synthetic method has been developed to prepare fluorescent silica nanoparticles without employing isothiocyanated dye molecules and (3-aminopropyl)triethoxysilane (APS) for the thiourea linkage formation; resulting show excellent photochemical, thermal pH stabilities a good biocompatibility with over 85% viability from various cell types.
Phosphorus-based food additives can substantially increase total phosphorus intake per day, but the effect of these on endocrine factors regulating bone and mineral metabolism is unclear.This study aimed to examine markers metabolism. Design Setting, Participants: This was a feeding 10 healthy individuals fed diet providing ∼1000 mg phosphorus/d using foods known be free for 1 week (low-additive diet), immediately followed by containing identical items; however, contained (additive-enhanced...
SiO<sub>2</sub>–polyimide nanocomposites having enhanced processability, thermal and mechanical properties were easily fabricated by the surface modification of silica nanoparticles with functional groups chemical structural similarity to polyimide chain.
Hydroxyapatite (HAp) is critical to health both as the main structural material of skeleton and storage calcium phosphate. Nanosized HAp (nHAp) naturally produced by mineralizing cells during bone formation remodeling constituent skeleton. As such, currently being investigated a therapeutic biomaterial for orthopedic dental purposes. Recent studies have suggested that extracellular nHAp can influence osteoblast lineage commitment cell function through changes in gene expression; however,...
We have successfully fabricated triacetylcellulose (TAC) polymer−silica nanocomposite films having up to 40 wt % of incorporated silica nanoparticles by deliberately designing a surface ligand that has structure similar polymer repeating units and effectively modifying the through chemical bonding. Cross-sectional TEM analysis reveals no significant aggregation in all TAC−silica films. Thermal results suggested nanocomposites had higher Tg Tc values as compared pure TAC, increase was...
Trialkoxysilyl terminal groups were directly introduced into fluorescent organic dye molecules by consecutive allylation and hydrosilation reactions; the derivatized then successfully embedded silica nanoparticles Stöber method. Those (FSNPs) had emission colors corresponding to each used (yellowish-green red) showed excellent thermal photochemical stabilities. A white light-emitting diode (WLED) was fabricated combining FSNP/silicone encapsulant composite incorporated with FSNPs having...
The phosphorescent Ir(III) complexes were modified by allylation and consecutive hydrosilylation, covalently incorporated into the silica nanoparticles hydrolysis condensation reaction with TEOS. These showed an excellent photochemical thermal stability, a very high luminescent efficiency due to blocking of O2 quenching suppression energy transfer through amorphous solid solution. limited mobility in matrix also resulted decrease vibration relaxation restrained nonradiative decay. It is...
Image-guided intra-arterial therapies play a key role in the management of hepatic malignancies. However, limited clinical outcomes suggest need for new multifunctional drug delivery systems to enhance local concentration while reducing systemic adverse reactions. Therefore, we developed albumin-doxorubicin nanoparticle conjugated microbubble (ADMB) therapeutic efficiency by sonoporation under exposure ultrasound. ADMB demonstrated size distribution 2.33 ± 1.34 µm and doxorubicin loading...
Nanomaterials are diverse in size, shape and charge these differences likely alter their physicochemical properties biological systems. We have investigated how the initial long-term dynamics of endocytosis, cell viability, division, exocytosis, interaction with a collagen extracellular matrix using silica-based fluorescent nanoparticles murine pre-osteoblast line, MC3T3-E1. Three surface modified were analyzed: positively charged (PTMA), negatively (OH), neutrally polyethylene glycol (PEG)....
Background: Crossing the blood-brain barrier (BBB) is crucial for drug delivery to brain and treatment of tumors, such as glioblastoma, most common all primary malignant tumors. Microbubble (MB) oscillated destroyed by controlling ultrasound (US) parameters. This oscillation destruction MB can open BBB transiently, a be delivered brain. Materials methods: For testing efficiency brain, we synthesized US-sensitizing nanoparticle (NP) complex via chemically binding MBs NPs opening, including...
Multimodal nanomaterials are useful for providing enhanced diagnostic information simultaneously a variety of in vivo imaging methods. According to our research findings, these multimodal offer promising applications cancer therapy.Melanin nanoparticles can be used as platform material and they simply produced by complexation with various active ions. They capable specifically targeting epidermal growth factor receptor (EGFR)-expressing cells being anchored specific antibody. Ion-doped...
A highly sensitive on‐site colorimetric forensic sensor has been developed for the quantitative detection of hydrogen sulfide and ammonia gases. The consists metal‐ion‐modified silica‐gel powders placed in a glass tube. powder color changes upon reaction with toxic It is capable easily detecting gases concentration range between 100 ppm, which considered as immediately dangerous to life health, 3000 may cause death, by using tube an inner diameter 3 mm. As reported here insensitive...