A5057516610- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Orthopaedic implants and arthroplasty
- Innovative Microfluidic and Catalytic Techniques Innovation
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Chemical Synthesis and Characterization
- Additive Manufacturing and 3D Printing Technologies
- Nanoplatforms for cancer theranostics
- Caveolin-1 and cellular processes
- Periodontal Regeneration and Treatments
- Photosynthetic Processes and Mechanisms
- Immune cells in cancer
- CAR-T cell therapy research
- Bone Metabolism and Diseases
- Tissue Engineering and Regenerative Medicine
- Bone health and treatments
- Cancer Cells and Metastasis
- Surgical Sutures and Adhesives
- Electrospun Nanofibers in Biomedical Applications
- X-ray Diffraction in Crystallography
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Calcium Carbonate Crystallization and Inhibition
- Magnesium Alloys: Properties and Applications
- Hemostasis and retained surgical items
Brigham and Women's Hospital
2016-2024
Harvard University
2016-2024
Women's Hospital
2016-2022
Massachusetts Institute of Technology
2016-2018
Harvard University Press
2018
Innovation Research Center
2016-2017
Harvard–MIT Division of Health Sciences and Technology
2016-2017
Seoul National University
2009-2017
University of Seoul
2014
The development of a multimaterial extrusion bioprinting platform is reported. This capable depositing multiple coded bioinks in continuous manner with fast and smooth switching among different reservoirs for rapid fabrication complex constructs, through digitally controlled from single printhead consisting bundled capillaries synergized programmed movement the motorized stage.
The development of a water oxidation catalyst has been demanding challenge in realizing splitting systems. asymmetric geometry and flexible ligation the biological Mn4CaO5 cluster are important properties for function photosystem II, these can be applied to design new inorganic catalysts. We identified crystal structure, Mn3(PO4)2·3H2O, that precipitates spontaneously aqueous solution at room temperature demonstrated its high catalytic performance under neutral conditions. bulky phosphate...
Blood vessels and nerve fibers are distributed throughout the entirety of skeletal tissue, play important roles during bone development fracture healing by supplying oxygen, nutrients, cells. However, despite successful mimetic materials that can replace damaged from a structural point view, most available biomaterials often do not induce sufficient formation blood nerves. In part, this is due to difficulty integrating regulating multiple tissue types within artificial materials, which...
Abstract The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and postoperative bacterial infections subsequent to the surgical removal of tumors have highlighted need for multifaceted scaffolds that afford tumor therapy, effective vascularized reconstruction. However, challenging trilemma has emerged in realm balance between achieving appropriate mechanical strength, ensuring biocompatibility, optimizing a degradation rate aligns with bone‐regenerative rate....
The synthesis of pure whitlockite (WH: Ca18Mg2(HPO4)2(PO4)12) has remained a challenge even though it is the second most abundant inorganic in living bone. Although few reports about precipitation WH heterogeneous phases have been published, to date, synthesizing without utilizing any effects buffer or various other ions remains difficult. Thus, related research fields encountered difficulties and not fully developed. Here, we developed large-scale method for nanoparticles ternary...
Chondroitin sulfate (CS) is the major component of glycosaminoglycan in connective tissue. In this study, we fabricated methacrylated PEGDA/CS-based hydrogels with varying CS concentration (0, 1, 5, and 10%) investigated them as biomineralizing three-dimensional scaffolds for charged ion binding depositions. Due to its negative charge from group, exhibited an osteogenically favorable microenvironment by ions such calcium phosphate. Particularly, distribution within negatively hydrogel was...
Biomimicking ceramics have been developed to induce efficient recovery of damaged hard tissues. Among them, calcium phosphate‐based bioceramics the most widely used because their similar composition with human tissue and excellent biocompatibilities. However, incomplete understanding entire inorganic phases in natural bone has limited recreation complete compositions. In this work, broad biomedical evaluation whitlockite (WH: Ca 18 Mg 2 (HPO 4 ) (PO 12 ), which is secondary phase bone,...
Abstract Orthopedic implants should have sufficient strength and promote bone tissue regeneration. However, most conventional are optimized for use either under high mechanical load or active osseointegration. To achieve the dual target of durability biocompatibility, polyether ether ketone (PEEK) filaments reinforced with internal titanium dioxide (TiO 2 ) nanoparticles via dopamine‐induced polymerization additively manufactured into an orthopedic implant through material extrusion (ME)....
The use of immune checkpoint inhibitors, which activate T cells, is a paradigm shift in the treatment non–small cell lung cancer. However, overall response remains low. To address this limitation, here we describe novel platform, termed antibody-conjugated drug-loaded nanotherapeutics (ADN), combines immunotherapy and molecularly targeted therapy. An ADN was designed with an anti-CD47 anti–programmed death ligand 1 (PDL1) antibody pair on surface nanoparticle inhibitor PI3K...
Hemostatic devices are critical for managing emergent severe bleeding. With the increased use of anticoagulant therapy, there is a need next-generation hemostats. We rationalized that hemostat with an architecture designed to increase contact blood, and engineered from material activates distinct undrugged coagulation pathway can address emerging need. Inspired by lung alveolar architecture, here, we describe engineering single-phase chitosan tortuous spherical microporous design enables...
Whitlockite (WH: Ca18Mg2(HPO4)2(PO4)12) is the second most abundant mineral in hard tissues, but its precipitation mechanism or role body system poorly understood. Here, using a newly discovered synthetic method for WH, we investigated kinetic of WH under physiologically similar conditions, excluding any effects toxic ions. Based on systematically classified stages process monitored transformation calcium phosphate phases from neutral pH to acidic with addition H3PO4. The study revealed that...
We developed an injectable osteogenic hydrogel that can deliver cells and endothelial growth factors.
We developed a NASH-on-a-chip where human primary hepatocytes (HCs), Kupffer cells (KCs), and hepatic stellate (HSCs) were cultured in the 3D hydrogel scaffold, while blood vessel mimetic endothelialized inlet channel was engineered using liver sinusoidal endothelial (LSECs), via which system exposed to metabolic inflammatory stressors. Exposing chips lipotoxic environment led gradual development of NASH phenotypic characteristics, including intracellular lipids accumulation, hepatocellular...
The so‐called Z‐scheme is a means of utilizing photo‐induced electrons from photosystem and has consistently motivated the design synthetic photocatalytic systems. Although progress been made in many pioneering studies on an inorganic‐based Z‐scheme, there have no reports hybrid for inorganic photosystem. Here, demonstrated by integrating platinized I (PSI) BiVO 4 hydrogen production. Up to now, PSI‐driven systems limited one‐step photoreduction reaction using sacrificial reductants. In this...
PEEK is a bioinert material that does not chemically bind to native bone tissue and thus formation of natural bone-like hydroxyapatite (HA) coating layer on has been an important challenge improve biocompatibility preserve mechanical property PEEK. Among various techniques, cold-spray method suitable form stable HA while maintaining their chemical properties, because it can be conducted in relatively low-temperature range. Therefore, this research, we used thick the topographically complex...
The noble synthesis method for hydroxyapatite (HAp) nanoparticles was exploited using a fairly simple reaction of Ca(OH)2 and H3PO4, which does not generate residual harmful anions consequently need an additional washing process. HAp were found to yield from dicalcium phosphate dehydrate (DCPD) as the only intermediate phase, monitored by in situ observation study X-ray diffraction (XRD), Fourier transform infrared (FT-IR), 1H 31P magic-angle spinning (MAS) NMR. Furthermore, we that phase...