The development of technology enables the reduction material size in science. use particle from micro to nanoscale not only provides benefits diverse scientific fields but also poses potential risks humans and environment. For successful application nanomaterials bioscience, it is essential understand biological fate toxicity nanoparticles. aim this study was evaluate distribution as well magnetic nanoparticles enable their applications life science, such drug development, protein detection,...

Cells in motion: Multifunctional nanoparticles, with a unique combination of magnetic and fluorescent properties, coupled biocompatibility are prepared. The uptake the nanoparticles by cells is investigated, an external “magnetic motor effect” on containing observed (see scheme). Supporting information for this article available WWW under http://www.angewandte.org or from author. Please note: publisher not responsible content functionality any supporting supplied authors. Any queries (other...

Organic dye-incorporated smart silica-coated core–shell magnetic nanoparticles (MNP@SiO2) having dual-functionality (-PEG/NH2, see Figure) were easily fabricated, and the amine moieties on NP surface modified with maleimide functionality for specific covalent immobilization of biopolymers bioactive small molecules. The sequence-independent antibodies (Ab) is highlighted; Ab-modified MNP@SiO2 particles exhibit recognition floating tumor cells or target membrane adherent breast cancer cells.

The surface of magnetic ferrite nanoparticles (CoFe2O4) was coated with a Rh-based cationic complex, [Rh(cod)(η6-benzoic acid)]BF4, to make them homogeneously dispersable and thermodynamically stable without an excess amount capping molecules in normal organic solvents. Since themselves have strong properties could be considered as nanometer-sized solid support for the surface-anchored catalyst, nanoparticle-supported Rh catalyst showed very effective catalytic activity toward...

Catching bugs: A highly sensitive and fast detection system was developed for infectious agents. In this approach, bacteria were incubated with magnetic nanoparticles (MNPs), concentrated inside a microfluidic chamber, detected miniaturized NMR chip. The method showed unprecedented sensitivity, detecting 20 in 1 mL sample of sputum within 30 min.

Reducing the particle size of materials is an efficient and reliable tool for improving bioavailability a gene or drug delivery system. In fact, nanotechnology helps in overcoming limitations can change outlook world regarding science. However, potential harmful effect nanomaterial on workers manufacturing nanoparticles expected workplace lack information body distribution inhaled may pose serious problem. this study, we addressed question by studying mice using approximately 50-nm...

There is a growing need for fast, highly sensitive and quantitative technologies to detect profile unaltered cells in biological samples. Technologies current clinical use are often time consuming, expensive, or require considerable sample sizes. Here, we report diagnostic magnetic resonance (DMR) sensor that combines miniaturized NMR probe with targeted nanoparticles detection molecular profiling of cancer cells. The measures the transverse relaxation rate water molecules samples which...

Sensitive and quantitative measurements of clinically relevant protein biomarkers, pathogens cells in biological samples would be invaluable for disease diagnosis, monitoring malignancy, evaluating therapy efficacy.Biosensing strategies using magnetic nanoparticles (MNPs) have recently received considerable attention, since they offer unique advantages over traditional detection methods.Specifically, because negligible background, MNPs can used to obtain highly sensitive minimally processed...

In our earlier work, we developed a 2-kg NMR system, which was 60 X lighter, 40× smaller, yet 60× more spin-mass sensitive than 120-kg state-of-the-art commercial benchtop system. Here report on two new nuclear magnetic resonance (NMR) systems that represent further orders-of-magnitude size reduction and lab-on-a-chip capability. The first weighs 0.1 kg can be held in the palm of hand, is smallest system ever built, 1200× 150× It enabled by combining physics with CMOS RF transceiver. second...

The potent core: A new approach to preparing highly magnetic nanoparticles consisting of a ferromagnetic core (Fe) and an artificial ferrite shell was developed. monometallic contributes high overall magnetization. superparamagnetic protects the against oxidation further increases magnetization while minimizing particle aggregation.

Magnetic relaxation switching (MRSw) assays that employ target-induced aggregation (or disaggregation) of magnetic nanoparticles (MNPs) can be used to detect a wide range biomolecules. The precise working mechanisms, however, remain poorly understood, often leading confounding interpretation. We herein present systematic and comprehensive characterization MRSw sensing. By using different types MNPs with varying physical properties, we analyzed the nature transverse modes for detection. study...

Nanomaterials are used in diverse fields including food, cosmetic, and medical industries. Titanium dioxide nanoparticles (TiO2-NP) widely used, but their effects on biological systems mechanism of toxicity have not been elucidated fully. Here, we report the toxicological TiO2-NP cell organelles. Human bronchial epithelial cells (16HBE14o-) were exposed to 50 100 μg/mL for 24 48 h. Our results showed that induced endoplasmic reticulum (ER) stress disrupted mitochondria-associated membranes...

Protein-based Cas9 in vivo gene editing therapeutics have practical limitations owing to their instability and low efficacy. To overcome these obstacles improve stability, we designed a nanocarrier primarily consisting of lecithin that can efficiently target liver disease encapsulate complexes with single-stranded guide RNA (sgRNA) ribonucleoprotein (Cas9-RNP) through polymer fusion self-assembly. In this study, optimized an sgRNA sequence specifically for dipeptidyl peptidase-4 (DPP-4)...

Rapid and accurate measurements of protein biomarkers, pathogens cells in biological samples could provide useful information for early disease diagnosis, treatment monitoring, design personalized medicine. In general, have only negligible magnetic susceptibility. Thus, using nanoparticles biosensing not enhances sensitivity but also effectively reduces sample preparation needs. This review focuses on the use vitro detection biomolecules based resonance effects. platform, termed diagnostic...

Highly potent magnetic nanomaterials are developed by encasing multiple cores inside a thin silica shell, in much the same way as pomegranate fruit contains many seeds within skin. This construct not only produces materials that biocompatible but also ones reach theoretically maximum transverse relaxivity. Detailed facts of importance to specialist readers published "Supporting Information". Such documents peer-reviewed, copy-edited or typeset. They made available submitted authors. Please...

Objective: To synthesize mesoporous silica-core-shell magnetic nanoparticles (MNPs) encapsulated by liposomes (Lipo [MNP@m-SiO2]) in order to enhance their stability, allow them be used any buffer solution, and produce trastuzumabconjugated (Lipo[MNP@m-SiO2]-Her2Ab) utilized vitro for the targeting of breast cancer. Materials Methods:The physiochemical characteristics Lipo[MNP@m-SiO2] were assessed terms size, morphological features, safety.The multimodal imaging properties organic dye...

Background/Objectives: C24 ceramide plays a crucial role in skin regeneration and wound healing; however, its hydrophobic nature limits application therapeutic formulations. This study aims to enhance the bioavailability efficacy of by developing ceramide-based lipid nanoparticles (C24-LNP) evaluate their impact on healing. Methods: C24-LNP was synthesized characterized for aqueous stability bioavailability. In vitro experiments were conducted assess effects keratinocyte proliferation...

Zellen in Bewegung: Multifunktionelle, biokompatible Nanopartikel mit einer einzigartigen Kombination von magnetischen und Fluoreszenzeigenschaften wurden hergestellt. Anschließend wurde ihre Aufnahme durch untersucht ein externer "Magnetmotoreffekt" auf die Nanopartikel-haltigen nachgewiesen (siehe Schema). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery,...

Monocytes are circulating macrophage and dendritic cell precursors that populate healthy diseased tissue. In humans, monocytes consist of at least two subsets whose proportions in the blood fluctuate response to coronary artery disease, sepsis, viral infection. Animal studies have shown specific shifts monocyte subset repertoire either exacerbate or attenuate suggesting a role for as biomarkers therapeutic targets. Assays therefore needed can selectively rapidly enumerate their subsets. This...