Cisplatin has multiple cellular targets and modes of action that lead to nephrotoxicity. This suggests novel therapies act at cisplatin target sites may be effective. We tested whether human adipose tissue-derived mesenchymal stem cells (Ad-MSCs) can affect protect against cisplatin-induced kidney damage. Rats were divided into four groups: control, infused with Ad-MSCs, injected cisplatin, followed by infusion Ad-MSCs. Animal survival renal function decreased histological damage was...

Objectives Fish bone impaction in the upper gastrointestinal tract is a common reason for patients to seek emergent care. The aim of this study was find clinical characteristics with fish tract. Methods conducted on 286 ingestion who complained dysphagia and irritation after eating fish. were treated according hospital protocol regarding removal bone. parameters analysis included age sex patients, location foreign body, method removal, type Results could be observed by physical examination...

Sox2 is a key transcription factor that maintains the proliferation of neuroglial stem cells and inhibits neuronal fate commitment. Moreover, it was recently found brain tumors contain resemble normal in many respects. This study undertaken to describe expression various tumors, determine whether universal feature or its limited specific lineage tumors. immunohistochemistry performed on 194 tumor tissues kinds. Fetal adult obtained by autopsy epilepsy patients with cortical dysplasia were...

Objectives: Little is known about the pathogenetic etiology of central pain in patients with traumatic brain injury (TBI). We investigated relation between spinothalamocortical tract (STT) and chronic mild TBI. Design: Retrospective survey. Participants: recruited 40 consecutive TBI 21 normal control subjects: 8 were excluded by inclusion criteria remaining 32 finally recruited. The classified according to 2 groups based on presence pain: group (22 patients) nonpain (10 patients). Methods:...

Cisplatin is a chemotherapeutic drug but induces acute kidney injury (AKI). Cisplatin-induced AKI depends on several signaling pathways leading to apoptosis in tubular epithelial cells. Glutamine substrate for the synthesis of glutathione, most abundant intracellular thiol and antioxidant, plays an important role protecting cells from induced by different stimuli. In present study, we investigated protective effect glutamine cisplatin-induced AKI. Rats were divided into control, glutamine,...

This study examined the functional significance of heme oxygenase-1 (HO-1) expression on renal injury induced by ureteral obstruction in rat kidney. Male Sprague-Dawley rats were divided into three groups, after which unilateral (UUO) was performed: untreated (group 1), treated with 30 mg/kg body wt hemin 2), and 50 microg/kg zinc (alpha) protoporphyrin eta (ZnPP) 3). After 7 14 d, histologic changes HO-1, Bcl-2, Bad, TGF-beta, cleaved caspase-3 examined. Tubular lumens dilated epithelial...

Abstract Circulating endothelial progenitor cells (EPCs) play an important role in physiological and pathological neovascularization may be involved attenuating ischemic diseases. This study aimed to characterize circulating EPCs moyamoya disease (MMD), one of the most common pediatric cerebrovascular Twenty‐eight children with MMD prior any surgical treatment 12 healthy volunteers were recruited. Peripheral blood mononuclear (PBMNCs) isolated cultured cell growth medium. Temporal change...

Tubular cell apoptosis is linked to the development of acute kidney injury (AKI), which a frequent complication traumatic rhabdomyolysis. The 14-3-3 protein, multifunctional regulatory binds variety apoptotic proteins and target c-Jun N-terminal kinase (JNK) in death signaling pathway. Therefore, we examined whether JNK phosphorylates downstream mitochondrial pathway mediates myoglobinuric determine these events are regulated by glutamine, known induce heat shock protein 70 (Hsp70), or...

Radiation therapy is a highly effective treatment for patients with solid tumors. However, it can cause damage and inflammation in normal tissues. Here, we investigated the effects of alpha-lipoic acid (ALA) as radioprotection agent small intestine mouse model.Whole abdomen was evenly irradiated total dose 15 Gy. Mice were treated either ALA (100 mg/kg, intraperitoneal injection [i.p.]) or saline (equal volume, i.p.) prior to radiation 100 mg/kg/day 3 days. Body weight, food intake,...

The objective of this study was to determine the effect a home-based exercise program on fatigue, anxiety, quality life (QoL), and immune function thyroid cancer patients taking hormone replacement after thyroidectomy.This quasi-experimental with non-equivalent control group included 43 outpatients thyroidectomy (22 in experimental 21 group). After education about program, subjects underwent 12 weeks aerobic, resistance, flexibility exercise. A comparative analysis conducted between two...

The use of colistin in the treatment multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated effects aged black garlic extract (ABGE) on colistin-induced kidney injury rats. Rats were assigned four groups. Normal saline was intraperitoneally and intragastrically injected for control group. ABGE Ten mg/kg 6 consecutive days One percent done 30 min prior injection sacrificed next day after last injection. Colistin increased serum levels blood...

Acute kidney injury (AKI) is the most common condition in hospitalized patients. As ischemia/reperfusion-induced AKI (IR-AKI) as a major contributor to end-stage disease, an effective therapeutic intervention for IR-AKI imperative. Erythropoietin (EPO) potent stimulator of erythroid progenitor cells and significantly upregulated during hypoxia. Here, we investigated renoprotective effects EPO mouse model. Mice were assigned sham, only, IR only groups, group was treated with prior injury....

Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired renal failure, with an incidence 11%. However, disease mechanism remains unclear, and no effective treatment available. Paricalcitol has been reported to be in animal models injury. We hypothesized that paricalcitol could play a renoprotective role against CI-AKI. Rats were divided into control, paricalcitol, contrast, paricalcitol-plus-contrast groups. used previously published protocol produce...

Exposure of the thyroid to radiation during radiotherapy head and neck is often unavoidable. The present study aimed investigate protective effect α-lipoic acid (ALA) on radiation-induced injury in rats. Rats were randomly assigned four groups: healthy controls (CTL), irradiated (RT), received ALA before irradiation (ALA + RT), only (ALA, 100 mg/kg, i.p.). was treated at 24 h 30 minutes prior irradiation. area including gland evenly with 2 Gy per minute (total dose 18 Gy) using a photon 6-MV...

Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small lung (NSCLC). Although both SCCs ACs have been characterized histologically clinically, precise mechanisms underlying their migration invasion not yet known. Here, we address involvement in NSCLC p21-associated kinase1 (Pak1)/LIM (LIMK1)/cofilin pathway, which recently has reported to play a critical role tumor invasion. The Pak1/LIMK1/cofilin pathway was evaluated tumors from SCC (n=35) AC...

// Jin Hyun Kim 1, 2 , Kyung Mi 3 Myeong Hee Jung 1 Hwa 2, 4 Ki Mun Kang 5 Bae Kwon Jeong Pyeong Je Park Seung Hoon Woo Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, Gyeongnam, Republic of Korea Institute Health Science, Department Otolaryngology, Internal Medicine, Radiation Oncology, School Medicine and Correspondence to: Woo, email: lesaby@hanmail.net Keywords: alpha lipoic acid, salivary gland, radiation, Nox-2, complication Received: December 27, 2015...

Radiotherapy (RT) is one of main strategies cancer treatment. However, some cells are resistant to radiation-induced cell death, including apoptosis. Therefore, alternative approaches targeting different anti-tumor mechanisms such as senescence required. This study aimed investigate the synergistic effect alpha-lipoic acid (ALA) on death and in MDA-MB-231 human breast cells.The were divided into four groups depending treatment (control, ALA, RT, ALA+RT). Cells analyzed for morphology,...

Background. Macrophages play diverse roles in tissue injury. We evaluated their role cyclosporine (CsA)-induced renal injury by depletion with liposomal clodronate (CL). Methods. Male Sprague Dawley rats were treated CsA or without CL treatment for 28 days. assessed responses from the pathology and measuring functions levels of a proinflammatory cytokine (osteopontin), profibrotic (βig-h3), innate immune response markers (toll-like receptor 2 MHC class II molecules), apoptotic cell death...

Objectives/Hypothesis Several genes have been reported to be upregulated in human nasal polyps previous genetic analyses. Among these genes, periostin is known overexpressed obtained from aspirin‐sensitive patients. Using periostin‐null mice, we investigated the role of a murine model eosinophilic rhinosinusitis with polyps. Study Design Animal study. Methods Eosinophilic was induced both and wild‐type mice according previously established protocols. In brief, ovalbumin (OVA) used for...