In this study, we aimed to evaluate the anticancer effect of benzimidazole derivatives on triple-negative breast cancer (TNBC) and investigate its underlying mechanism action. Several types normal cells including MDA-MB-231, radiotherapy-resistant (RT-R) allograft mice were treated with six mebendazole (MBZ). Cells analyzed for viability, colony formation, scratch wound healing, Matrigel invasion, cell cycle, tubulin polymerization, protein expression by using Western blotting. mice, liver...

Radiation therapy is a highly effective treatment for patients with solid tumors. However, it can cause damage and inflammation in normal tissues. Here, we investigated the effects of alpha-lipoic acid (ALA) as radioprotection agent small intestine mouse model.Whole abdomen was evenly irradiated total dose 15 Gy. Mice were treated either ALA (100 mg/kg, intraperitoneal injection [i.p.]) or saline (equal volume, i.p.) prior to radiation 100 mg/kg/day 3 days. Body weight, food intake,...

Background We compared the treatment outcomes of stereotactic body radiotherapy (SBRT) and metastasectomy in patients with pulmonary metastases. Methods Twenty‐one received SBRT (total radiation doses 60 Gy 3 fractions or 48 4 fractions) 30 underwent metastasectomy, most (93.3%) wedge resection. The were followed for a median 13.7 months. tumor size group was larger than (median 2.5 vs. 1.25 cm; P = 0.015). Patients synchronous metastases more likely to be treated ( 0.006). Results There no...

Local radiotherapy (RT) is important to manage metastatic triple-negative breast cancer (TNBC). Although RT primarily reduces cells locally, this control can be enhanced by triggering the immune system via immunotherapy. and immunotherapy may lead an improved systemic effect, known as abscopal effect. Here, we analyzed antitumor effect of combination therapy using with anti-programmed cell death-1 (PD-1) antibody in primary tumors, poorly immunogenic mouse mammary carcinoma 4T1 model. Mice...

This study examined the dose response of an optically stimulated luminescence dosemeter (OSLD) to megavoltage photon and electron beams. A nanoDot™ was used measure OSLD. Photons 6–15 MV electrons 9–20 MeV were delivered by a Varian 21iX machine (Varian Medical System, Inc. Milpitas, CA, USA). The energy dependency <1 %. For 6-MV photons, linear until 200 cGy. superficial measurements revealed irradiation have angular dependency. has potential use as in vivo dosimetric tool that is...

The eighth tumor, node, metastasis (TNM) staging system (8-TNM) for non-small cell lung cancer (NSCLC) was newly released in 2015. This had limitation because most patients included the analysis were treated with surgery. Therefore, it might be difficult to reflect prognosis of curative concurrent chemoradiotherapy (CCRT). Purpose this study investigate clinical impact published 8-TNM compared current seventh TNM (7-TNM) locally advanced NSCLC CCRT. New applied 64 who CCRT from 2010 Changes...

The role of adjuvant radiotherapy (RT) and setting proper RT target volumes have not been clearly demonstrated for extrahepatic bile duct (EHBD) cancer, due to the rarity disease lack randomized trials. This study was conducted evaluate indication treatment volume in EHBD cancer patients by identifying prognostic factors loco-regional (LR) failure, analyze patterns LR failure.Ninety-three with who underwent resection without RT, at 2 medical centers, between 2001 2016, were analyzed...

Radiotherapy (RT) is one of main strategies cancer treatment. However, some cells are resistant to radiation-induced cell death, including apoptosis. Therefore, alternative approaches targeting different anti-tumor mechanisms such as senescence required. This study aimed investigate the synergistic effect alpha-lipoic acid (ALA) on death and in MDA-MB-231 human breast cells.The were divided into four groups depending treatment (control, ALA, RT, ALA+RT). Cells analyzed for morphology,...

To compare the dose distribution between carotid sparing intensity modulated radiotherapy (IMRT) and opposed lateral field technique (LAFT), to determine effects of IMRT in early glottic cancer patients who have risk factors for atherosclerosis.Ten were treated with IMRT. For each patient, conventional LAFT plan was developed comparison. plans compared terms planning target volume (PTV) coverage, conformity index, homogeneity doses organ at (PRV) arteries, spinal cord pharyngeal constrictor...

To identify the factors that predict progression of radiological radiation pneumonitis (RP) to symptomatic RP, and evaluate usefulness neutrophil-lymphocyte ratio (NLR) as a marker RP severity prognosis in stage III non-small cell lung cancer (NSCLC) patients treated with definitive concurrent chemoradiotherapy (CCRT).We retrospectively reviewed 61 between January 2010 December 2015. Patients' demographic characteristics, clinical data, laboratory findings treatment parameters were analyzed...

Abstract Aim Stereotactic‐body radiotherapy (SBRT) is a treatment option for portal vein tumor thrombosis (PVTT) in patients with hepatocellular carcinoma (HCC). Here, we report on our experience of treating PVTT using SBRT concomitant underlying chronic liver disease. Methods This study included 24 patients. The initial prescription dose was 45 Gy three fractions 17 (70.8%) patients, but it modified the remaining seven (29.2%) ranging from 39 to 42 3‐4 fractions. After SBRT, transarterial...

The definition and criteria of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients vary among studies. Therefore, the reported rates RIHT differ studies, this causes confusion. In study, we evaluated using several laboratory clinical parameters, analyzed which criterion is more correlated with RT survival. Forty-five HCC treated stereotactic body radiotherapy were included for analysis. All had unresectable Child-Pugh (CP) class A or B baseline liver function....

Background A significant proportion of lung cancer patients suffer from malignant airway obstruction (MAO). Palliative external beam radiotherapy (EBRT) is often used to control the symptoms caused by MAO. In this study, we report effect palliative EBRT on with MAO and analyze factors that influence it. Methods This study included 75 in who underwent EBRT, between 2009 2018 were analyzed retrospectively. Change dyspnea, tumor response, overall survival (OS) recorded. Univariate multivariate...

Purpose: To examine the dosimetric effect of intrafraction movements occurred during image‐guided frameless brain radiosurgery and to derive optimal margin recipe compensate movement. Methods: The patients’ radiosurgeries were measured using skull‐tracking method incorporated in CyberKnife system. changes with computed six different dynamic‐arc treatment plans based on dose‐grid analysis method. authors extensively searched proper relationship between dose variations geometric errors. for...

We evaluated the effect of early chemoradiotherapy on treatment patients with limited stage small cell lung cancer (LS-SCLC).Between January 2006 and December 2011, thirty-one histologically proven LS-SCLC who were treated two cycles chemotherapy followed by concurrent consolidation retrospectively analyzed. The regimen was composed etoposide cisplatin. Thoracic radiotherapy consisted 50 to 60 Gy (median, 54 Gy) given in 5 6.5 weeks.The follow-up period ranged from 53 months 22 months)....

Breast cancer is the most commonly diagnosed worldwide and ranks first in terms of both prevalence cancer-related mortality women. In this study, we aimed to evaluate anticancer effect mebendazole (MBZ) radiotherapy (RT) concomitant use triple-negative breast (TNBC) cells elucidate underlying mechanisms action. mouse models several types cells, including TNBC-derived RT-resistant (RT-R) MDA-MB-231 were treated with MBZ and/or RT. mice, changes body weight, renal liver toxicity, tumor volume,...

Background:To analyze clinical outcome of CyberKnife (CK) tumor-tracking stereotactic body radiotherapy (SBRT) for prostate cancer (Pca) according to the magnitude intrafractional motion.Methods: Medical records and daily treatment logs 71 patients who received CK tumortracking SBRT were retrospectively analyzed.Statistical relationships between motion various results, including local recurrence (LR), biochemical failure (BF), treatment-related toxicity, investigated in order evaluate...

// Jin Ho Song 1, 4 , Ki Mun Kang Hoon-Sik Choi 1 Hojin Jeong In Bong Ha Jong Deog Lee 2 Cheol Kim Yi Yeong Yu Ji Cho Seung Jun Sung Hwan 3 In-Seok Jang Bae Kwon Department of Radiation Oncology, Gyeongsang National University School Medicine and Hospital, Jinju, Republic Korea Internal Medicine, Thoracic Cardiovascular Surgery, Institute Health Sciences, University, Correspondence to: Jeong, e-mail: blue129j@gnu.ac.kr Keywords: stereotactic body radiotherapy, lung cancer, calculation...

We have investigated the combined effect of tissue heterogeneity and its variation associated with geometric error in stereotactic body radiotherapy (SBRT) for lung cancer. The treatment plans eight cancer patients were calculated using effective path length (EPL) correction Monte Carlo (MC) algorithms, both having same beam configuration each patient. These two kinds individual then subsequently recalculated adding systematic random errors. In ordinary no offset, EPL calculations, compared...