A5101692395- Endometrial and Cervical Cancer Treatments
- Molecular Sensors and Ion Detection
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Colorectal and Anal Carcinomas
- Luminescence and Fluorescent Materials
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Uterine Myomas and Treatments
- Analytical Chemistry and Sensors
- Bone health and osteoporosis research
- Medical Imaging Techniques and Applications
- Supramolecular Chemistry and Complexes
- Management of metastatic bone disease
- Superconducting Materials and Applications
- Electrochemical Analysis and Applications
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gynecological conditions and treatments
- Intraperitoneal and Appendiceal Malignancies
- Glioma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
Soonchunhyang University
2024-2025
Catholic University of Daegu
2018-2024
Daegu Catholic University Medical Center
2024
Samsung Medical Center
2000-2023
Sungkyunkwan University
2004-2023
Korea Forest Service
2019
Kyushu University
2019
Kyungpook National University Hospital
2016-2018
International St. Mary's Hospital
2017
Catholic Kwandong University
2017
A novel coumarin-based fluorogenic probe bearing the 2-picolyl unit (1) was developed as a fluorescent chemosensor with high selectivity and suitable affinity in biological systems toward Cu2+ over other cations tested. The fluorescence on−off mechanism studied by femtosecond time-resolved (TRF) upconversion technique ab initio calculations. receptor can be applied to monitoring of ion aqueous solution pH span 4−10. To confirm suitability 1 for applications, we also employed it detection...
A novel tren-based tripodal chemosensor 1 bearing a rhodamine and two tosyl groups was synthesized its sensing behavior toward metal ions investigated by UV/vis fluorescence spectroscopies. Addition of Hg2+ ion to CH3CN solution gave visual color change as well significantly enhanced fluorescence, while other including Pb2+, Zn2+, Cu2+, Ca2+, Ba2+, Cd2+, Co2+, Mg2+, Ag+, Cs+, Li+, Na+ induced no or much smaller color/spectral changes, which constituted Hg2+-selective fluorescent (OFF-ON).
Abstract Purpose: This study aimed to develop an Arg-Gly-Asp (RGD) peptide-labeled chitosan nanoparticle (RGD-CH-NP) as a novel tumor targeted delivery system for short interfering RNA (siRNA). Experimental Design: RGD peptide conjugated with by thiolation reaction was confirmed proton-NMR (H-NMR). Binding of RGD-CH-NP ανβ3 integrin examined flow cytometry and fluorescence microscopy. Antitumor efficacy in orthotopic mouse models ovarian carcinoma. Results: We show that loaded siRNA...
A novel calix[4]arene-based chemosensor 1 based on Hg2+-induced fluorescence resonance energy transfer (FRET) was synthesized, and its sensing behavior toward metal ions investigated by UV/vis spectroscopies. Addition of Hg2+ to a CH3CN solution gave significantly enhanced at ∼575 nm via (FRET-ON) from the pyrenyl excimer ring-opened rhodamine moiety. In contrast, addition Al3+ induced distinct increase emission (∼475 nm), while no obvious FRET-ON phenomenon observed. Different binding...
The fluorescence of NABQ increases remarkably in the presence Zn(2+) and is quenched by Hg(2+). As shown confocal imaging, NABQ-Zn(2+) can penetrate cells, where bound exchanged for This results concomitant export Hg(2+) from showing that act as a carrier extracting agent living cells.
1,3-Alternate calix[4]arene-based fluorescent chemosensors bearing two-photon absorbing chromophores have been synthesized, and their sensing behaviors toward metal ions were investigated via absorption band shifts as well one- fluorescence changes. Free ligands absorb the light at 461 nm weakly emit 600 when excited by UV−vis radiation nm, but no is emitted excitation 780 nm. Addition of an Al3+ or Pb2+ ion to a solution ligand causes blue-shifted enhanced due declined resonance energy...
There is no definitive guideline for the significance and cut-off value of squamous-cell carcinoma antigen (SCC-Ag) in cervical cancer. Thus, we analyzed optimal SCC-Ag predicting tumor recurrence patient survival uterine cervix.From January 2010 to October 2016, enrolled 304 cancer patients with staging International Federation Gynecology Obstetrics (FIGO) Ib-IVa treated chemoradiotherapy (CRT) followed by intra-cavitary radiotherapy (ICR). The level was calculated using receiver operating...
Background We compared the treatment outcomes of stereotactic body radiotherapy (SBRT) and metastasectomy in patients with pulmonary metastases. Methods Twenty‐one received SBRT (total radiation doses 60 Gy 3 fractions or 48 4 fractions) 30 underwent metastasectomy, most (93.3%) wedge resection. The were followed for a median 13.7 months. tumor size group was larger than (median 2.5 vs. 1.25 cm; P = 0.015). Patients synchronous metastases more likely to be treated ( 0.006). Results There no...
This study aimed to evaluate the prognostic value of fluorine-18 fluorodeoxyglucose (FDG) uptake bone marrow (BM) on positron emission tomography (PET)/computed in patients with uterine cervical cancer.One hundred forty-five cancer who underwent staging FDG PET/computed and subsequent surgical resection or chemoradiotherapy were retrospectively enrolled study. Mean BM (BM standardized [SUV]) BM-to-liver ratio (BLR) measured. Relationships SUV BLR hematologic inflammatory markers evaluated....
Abstract Background Secondary cytoreductive surgery (SCS) is possible in selected patients with recurrent epithelial ovarian cancer (EOC). The goal of SCS complete resection, although chemotherapy always followed. Delayed intervals between primary debulking and adjuvant was reported to be associated poorer survivals, however, the role disease still unknown. Materials methods This retrospective cohort study reviewed data from electronic medical records women EOC treated at Samsung Medical...
The aim of the study was to evaluate pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) as prognostic factors for predicting clinical outcomes after definitive concurrent chemoradiotherapy (CCRT) cervical cancer. cases were divided into two groups based on values NLR PLR: High NLR-PLR (high value in both PLR) Low (low either or PLR). relationships between survival investigated. Of 148 patients enrolled study, 30 died during median follow-up 75 months. Based...
Lymph node metastasis (LNM) is the most significant prognostic factor in cervical cancer that was recently incorporated into International Federation of Gynecology and Obstetrics (FIGO) staging system. This study performed to evaluate whether significance LNM differs according disease status.
To elucidate the changes in bone turnover during pregnancy and puerperium, we measured serially levels of serum osteocalcin urine deoxypyridinoline (Dpy) as markers formation resorption, respectively, 22 healthy women with normal pregnancy. Nineteen non-pregnant served control. The Dpy increased significantly at 16 weeks remained elevated thereafter. osteocalcin, however, were decreased later 6 postpartum. Bone ratio (Dpy/osteocalcin) continued to rise pregnancy, but returned control after...
Osteoporosis is characterized by an abnormal loss of bone mineral content, which leads to a tendency non-traumatic fractures or structural deformations bone. Thus, density has been considered as most reliable parameter assess osteoporotic fracture risk. In past decades, the way, texture measures have studied estimate other aspect quality. Some studies performed on CT MR images quality using trabecular structure analysis. Other plain x-ray ultrasound structure. However, are focused individual...
To investigate the expressions of Fas and ligand (FasL) in human placenta, we studied FasL placenta with RT-PCR, immunoblotting immunostaining. We observed amplified products transcripts, band (52 kDa) multiple bands (42-52 placenta. localized mainly on fetal vessels syncytiotrophoblasts respectively. The differential distribution may reflect intrinsic them by trophoblasts during differentiation. increased expression promote apoptosis pathologic condition such as preeclampsia.
Background: This study aimed to assess the in-field lymph node (LN) failure rate according LN size and investigate effect of on survival outcome patients with locally advanced cervical carcinoma treated concurrent chemoradiotherapy (CCRT).Methods: A total 310 CCRT were enrolled in retrospective study.LN status was evaluated by magnetic resonance imaging.All received conventional external beam irradiation high-dose brachytherapy, cisplatin-based chemotherapy.In-field analyzed.Results: The...