A5029832903- Olfactory and Sensory Function Studies
- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Nasal Surgery and Airway Studies
- Obstructive Sleep Apnea Research
- Asthma and respiratory diseases
- Advanced Chemical Sensor Technologies
- Advanced Glycation End Products research
- Tracheal and airway disorders
- Allergic Rhinitis and Sensitization
- Oral and Maxillofacial Pathology
- Vascular Anomalies and Treatments
- Neuroscience of respiration and sleep
- Reconstructive Facial Surgery Techniques
- Biochemical Analysis and Sensing Techniques
- Facial Rejuvenation and Surgery Techniques
- Essential Oils and Antimicrobial Activity
- Bone Tumor Diagnosis and Treatments
- Air Quality and Health Impacts
- Infectious Diseases and Tuberculosis
- Meningioma and schwannoma management
- Infectious Diseases and Mycology
- Immune Response and Inflammation
- Microplastics and Plastic Pollution
- Migraine and Headache Studies
Chung-Ang University
2016-2025
Incheon National University
2025
Chung-Ang University Hospital
2019-2024
Biomedical Research Institute
2024
Hospital for Sick Children
2023
Duke University
2020-2021
Marcus (United States)
2020-2021
Seoul National University Bundang Hospital
2020
Yonsei University
2008-2017
May Institute
2016
Febrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and may trigger development febrile In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) cytokines, occurs in children with or epilepsy, we analyzed cytokine profiles patients epilepsy. Forty-one seizure who visited emergency department Seoul National University Boramae Hospital from June 2008 May 2009 were included this...
Abstract Lipopolysaccharide (LPS) triggers deleterious systemic inflammatory responses when released into the circulation. LPS‐binding protein (LBP) in serum plays an important role modifying LPS toxicity by facilitating its interaction with signaling receptors, which are expressed on surface of LPS‐responsive cells. We have previously demonstrated that high mobility group box 1 (HMGB1) can bind to and transfer LPS, consequently increasing LPS‐induced TNF‐α production human peripheral blood...
KEY POINTS Human nasal cavity samples were collected, and presence of microplastics evaluated. Microplastics present, major types polyethylene, polyester, acrylic polymer, polypropylene. Further research is needed regarding its clinical impact on human cavity.
The Korean Society of Otorhinolaryngology-Head and Neck Surgery Rhinologic appointed a guideline development group (GDG) to establish clinical practice guideline, the GDG developed for nasal irrigation adult patients with chronic rhinosinusitis (CRS). focuses on knowledge gaps, variations, concerns associated irrigation. Nasal has been recommended as first-line treatment CRS in various guidelines, its effectiveness demonstrated through number studies robust evidence. However, no guidelines...
We developed a novel injectable type I collagen/hyaluronic acid/fibrinogen (COL/HA/FG) composite gel that encapsulated synovium-derived mesenchymal stem cells (SDSCs) for the repair of damaged articular cartilage. first analyzed suitability as three-dimensional cell carrier in vitro. In an vivo rabbit model, COL/HA/FG displayed potential to regenerate and osteochondral defects knee. Culture SDSCs chondrogenic medium resulted high viability expressions II collagen, aggrecan, sox 9 mRNA....
Abstract High-mobility group box 1 protein (HMGB1), which mainly exists in the nucleus, has recently been shown to function as a sentinel molecule for viral nucleic acid sensing and an autophagy regulator cytoplasm. In this study, we studied chaperone-like activity of HMGB1 found that inhibited chemically induced aggregation insulin lysozyme, well heat-induced citrate synthase. also restored suppression cytoplasmic luciferase reporter hamster lung fibroblast O23 cells with expression HMGB1....
ABSTRACT Abnormalities in the human microbiota are associated with etiology of allergic diseases. Although disease site-specific may be pathophysiology, role nasal is unclear. We sought to characterize site rhinitis, inferior turbinate, subjects rhinitis ( n = 20) and healthy controls 12) examine relationship mucosal occurrence, sensitized allergen number, allergen-specific total IgE levels. Microbial dysbiosis correlated significantly levels representing combined responses but not number...
Histamine is an important mediator of allergic reactions, and mucus hypersecretion a major symptom. However, the direct effect histamine on secretion from airway mucosal epithelia has not been clearly demonstrated. TMEM16A Ca2+-activated chloride channel, it closely related to fluid in epithelia. We investigated whether directly induces epithelial cells or submucosal glands (SMG) mechanisms related, therewith, diseases. In pig tissues nose trachea, was potent secretagogue that induced strong...
Objectives The aim of this study was to identify correlations between sleep apnea severity and tongue volume or posterior airway space measured via three-dimensional reconstruction volumetric computerized tomography (CT) images in patients with obstructive (OSA) for use predicting OSA surgical treatment. We also assessed associations Mallampati score. Methods Snoring/OSA male (n = 64) who underwent polysomnography, cephalometry, CT scans were enrolled retrospective study. diagnosed when the...
Microplastics have been detected in various human organs, and studies on their impact health are ongoing. However, few researched microplastics the cervicovaginal area. In this study, we aimed to assess presence lavage fluid. This prospective study was conducted at a single tertiary medical center, enrolling 10 participants aged 27–49 years. Human fluid samples were collected from patients by skilled obstetrician. Raman spectroscopy used analyze characterize microplastic particles samples....
Objective High mobility group box 1 (HMGB1) protein is a chromatin that functions as proinflammatory cytokine when secreted in response to inflammatory stimuli. The purpose of this study was determine the relationship between HMGB1 level nasal secretions and severity inflammation chronic rhinosinusitis. Study Design This cross‐sectional study. Methods Nasal were obtained by irrigation affected sinonasal cavities with normal saline. Total 63 lavage fluid samples collected from 38 patients...
Abstract High-mobility group box 1 (HMGB1) functions as a transcription-enhancing nuclear protein well crucial cytokine that regulates inflammation. This study demonstrated secretion of HMGB1 due to ultraviolet (UV) radiation inducing ocular surface inflammation-mediated reactive oxygen species (ROS) production. After treating conjunctival epithelial cells with UV radiation, was translocated from the nucleus cytoplasm and then eventually extracellular space. played role in UV-induced...
Purpose:The nasal mucosa is the first site to encounter pathogens, and it forms continuous barriers various stimuli.This barrier function very important in innate defense mechanism.Additionally, inflammation of sinus known be a hypoxic condition.Here, we studied effect hypoxia on normal human epithelial (NHNE) cells.Materials Methods:The expression levels junction complex proteins were assessed hypoxia-stimulated NHNE cells mucosal tissues.We performed real-time polymerase chain reaction...