A5100721061- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Alzheimer's disease research and treatments
- Eicosanoids and Hypertension Pharmacology
- Genetics, Aging, and Longevity in Model Organisms
- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- Vibrio bacteria research studies
- Metabolism, Diabetes, and Cancer
- Pluripotent Stem Cells Research
- Endoplasmic Reticulum Stress and Disease
- Advanced Glycation End Products research
- Wound Healing and Treatments
- Pancreatic function and diabetes
- Genomics and Phylogenetic Studies
- Sirtuins and Resveratrol in Medicine
- Spaceflight effects on biology
- Cellular transport and secretion
- Advanced biosensing and bioanalysis techniques
- Air Quality and Health Impacts
- Nanoparticle-Based Drug Delivery
- Circadian rhythm and melatonin
Korea Advanced Institute of Science and Technology
2002-2025
National Institute of Biological Resources
2024
Institute of Molecular and Cell Biology
2023
Seoul National University
2004-2021
New Generation University College
2019-2020
National University College
2019-2020
Soonchunhyang University
2020
Korea University
2009-2011
Cells in motion: Multifunctional nanoparticles, with a unique combination of magnetic and fluorescent properties, coupled biocompatibility are prepared. The uptake the nanoparticles by cells is investigated, an external “magnetic motor effect” on containing observed (see scheme). Supporting information for this article available WWW under http://www.angewandte.org or from author. Please note: publisher not responsible content functionality any supporting supplied authors. Any queries (other...
Abstract Stress-induced glucocorticoids disturb mitochondrial bioenergetics and dynamics; however, instead of being removed via mitophagy, the damaged mitochondria accumulate. Therefore, we investigate role in mitophagy inhibition subsequent synaptic defects hippocampal neurons, SH-SY5Y cells, ICR mice. First, observe that decrease both density vesicle recycling due to suppressed mitophagy. Screening data reveal downregulate BNIP3-like (BNIP3L)/NIX, resulting reduced respiration function...
Organic dye-incorporated smart silica-coated core–shell magnetic nanoparticles (MNP@SiO2) having dual-functionality (-PEG/NH2, see Figure) were easily fabricated, and the amine moieties on NP surface modified with maleimide functionality for specific covalent immobilization of biopolymers bioactive small molecules. The sequence-independent antibodies (Ab) is highlighted; Ab-modified MNP@SiO2 particles exhibit recognition floating tumor cells or target membrane adherent breast cancer cells.
Recent evidence shows that amniotic fluid (AF) contains multiple cell types derived from the developing fetus, and may represent a novel source of stem cells for therapy. In this study, we examined paracrine factors released by human fluid–derived mesenchymal (AF-MSCs) their ability to accelerate wound-healing process stimulating proliferation migration dermal fibroblasts. AF-MSCs expressed typical MSC marker proteins CD13, CD29, CD44 differentiated into adipocytes, osteoblasts, chondrocytes...
Hyperglycemia is a representative hallmark and risk factor for diabetes mellitus (DM) closely linked to DM-associated neuronal cell death. Previous investigators reported on genome-wide association study showed relationships between DM melatonin receptor (MT), highlighting the role of MT signaling by assessing in DM. However, pathogenesis unclear. Therefore, we investigated mitophagy regulators high glucose-induced death effect against cells. In our results, glucose significantly increased...
Abstract The role of metabolites produced from stem cell metabolism has been emerged as signaling molecules to regulate behaviors such migration. mitochondrial morphology is closely associated with the metabolic balance and function. However, physiological succinate on human mesenchymal (hMSC) migration by regulating remains unclear. Here, we investigate effect hMSC via regulation dynamics its related pathway. Succinate (50 μM) significantly accelerates increases phosphorylation pan-PKC,...
Abstract Background Neurodegeneration is a representative phenotype of patients with chronic alcoholism. Ethanol-induced calcium overload causes NOD-like receptor protein 3 (NLRP3) inflammasome formation and an imbalance in mitochondrial dynamics, closely associated the pathogenesis neurodegeneration. However, how regulates this process neuronal cells poorly understood. Therefore, present study investigated detailed mechanism calcium-regulated dynamics NLRP3 by ethanol. Methods In study, we...
The gut-brain axis is currently being studied as a therapeutic strategy for neurological diseases, especially Alzheimer's disease (AD). Obesity results in the gut microbiota dysbiosis, which includes butyrate-producing bacteria are reduced. Although sodium butyrate (NaB) has emerged potential substance AD, there lack of detailed into what signaling pathways affect amyloidogenesis AD induced by obesity. Thus, we investigated regulatory role NaB on neuronal cells under high cholesterol. In our...
Making transparent aromatic polymers with high Tg and low thermal expansion behavior, like glass, is challenging. We report soluble poly(amide-imide)s (PAIs) dimensional stability synthesized from the new monomer, trifluoromethylated trimellitic anhydride. Insertion of trifluoromethyl (CF3) groups into polymer chains enhanced solubility optical properties without sacrificing stability. Model reactions were utilized to study how CF3 group in anhydride affects polymerization reaction diamine...
Accurate estimation of the exposure-response relationship between ambient urban particulate matters (PM) and public health is important for regulatory perspective (PM). Ambient PM contains various transition metals organic compounds. PM10 (aerodynamic diameter less than 10 micro m) known to induce diverse diseases such as chronic cough, bronchitis, chest illness, etc. However, recent evaluation PM2.5 2.5 against outcomes has suggested that fine particles may be more closely associated with...
Abstract VvhA, a virulent factor of Vibrio (V. ) vulnificus , induces acute cell death in destructive manner. Autophagy plays an important role death, but the functional VvhA autophagy-related has not been elucidated yet. We found that rVvhA significantly increased LC3 puncta formation and autophagic flux promoting human intestinal epithelial Caco-2 cells. The induced by was independent lysosomal permeabilizaton caspase activation. rapid phosphorylation c-Src membrane lipid raft, which...
Abstract Qualitative and quantitative analyses of reactive oxygen species (ROS) generated on the surfaces nanomaterials are important for understanding their toxicity toxic mechanisms, which in turn beneficial manufacturing more biocompatible many industrial fields. Electron spin resonance (ESR) is a useful tool detecting ROS formation. However, using this technique without first considering physicochemical properties proper conditions trapping agent (such as incubation time) may lead to...
Hypoxia-inducible factor 1 (HIF1) is a master transcription that induces the of genes involved in metabolism and behavior stem cells. HIF1-mediated adaptation to hypoxia required maintain pluripotency survival cells under hypoxic conditions. HIF1 activity well known be tightly controlled by alpha subunit (HIF1α). Understanding regulatory mechanisms control will provide novel insights into cell biology hypoxia. Recent research has unraveled mechanistic details HIF1α regulating processes,...
Hypoxia inducible factor 1α (HIF1α) is a master regulator leading to metabolic adaptation, an essential physiological process maintain the survival of stem cells under hypoxia. However, it poorly understood how HIF1α translocates into nucleus in Here, we investigated role motor adaptor protein Bicaudal D homolog 1 (BICD1) dynein-mediated nuclear translocation and effect BICD1 regulation on hypoxia adaptation its therapeutic potential human umbilical cord blood-derived mesenchymal (UCB-MSCs)....
Abstract Glucocorticoid, a major risk factor of Alzheimer’s disease (AD), is widely known to promote microtubule dysfunction recognized as the early pathological feature that culminates in memory deficits. However, exact glucocorticoid receptor (GR)-mediated mechanism how triggers destabilization and following intracellular transport deficits remains elusive. Therefore, we investigated effect on instability cognitive impairment using male ICR mice human neuroblastoma SH-SY5Y cells. The group...
We report the complete genome sequence of
A Gram-stain-negative, aerobic, oxidase-positive, weakly catalase-positive, motile by means of a single polar flagellum, rod-shaped bacterium designated as strain S2-9 T was isolated from sediment sampled in Wiyang pond, Republic Korea. Growth this observed at 10–40 °C (optimum, 35 °C) and pH 5.5–9.5 7.0–8.0) the presence 0–0.5 % NaCl Reasoner's 2A broth. The major fatty acids (>10 %) were C 16 : 0 summed feature 3 (comprising mixture 1 ω 7 c and/or 6 ). Ubiquinone-8 detected respiratory...