A5065670237- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Biopolymer Synthesis and Applications
- Antimicrobial Peptides and Activities
- Advanced Drug Delivery Systems
- DNA and Nucleic Acid Chemistry
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Trypanosoma species research and implications
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- CAR-T cell therapy research
- Click Chemistry and Applications
- Computational Drug Discovery Methods
- Nerve injury and regeneration
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Animal Genetics and Reproduction
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microbial Natural Products and Biosynthesis
- Synthesis of Tetrazole Derivatives
- Research on Leishmaniasis Studies
Seoul National University
2012-2025
Jain University
2024-2025
Government of the Republic of Korea
2015-2019
Seoul National University Dental Hospital
2013-2019
National Cancer Center
2018
Government Medical College
2015
Weatherford College
2009
In this era of competition quality has been given prime magnitude; failure to meet such allied goals produces massive shift company in share market. context pharmaceutical industry is utmost regulated as it governed by authoritative regulatory bodies. “Quality could be planned and most deficit arises the way process developed”, thought well known expert Joseph Moses Juran gives foundation concept design (QbD). USFDA launched a pilot programme 2005 permit participating firms prospect submit...
This review covers the current aspects of leishmaniasis including marketed drugs, new antileishmanial agents, and possible drug targets agents.
Despite the immense potential of non-viral delivery system in gene therapy its application has been impaired greatly by various impediments having contrasting traits. Therefore it is an absolute necessity to develop some vectors which are endowed with special characteristics act differently intracellular as well extracellular compartments surmount these inter-conflicting hurdles. Such smart polymers should serve specific purposes adjusting their structural or functional traits under...
Polyethylenimine (PEI) vectors are widely used in gene delivery because of their high transfection efficiency owing to a unique proton sponge effect. An increase molecular weight increases efficiency, but simultaneously results increased toxicity. Therefore, the design and synthesis new degradable carriers having efficiencies reduced cytotoxicity necessary.In present study poly(ester amines) (PEAs) based on glycerol dimethacrylate (GDM) low branched polyethylenimine (LMW-PEI) were...
Polyethylenimine (PEI) is a well-known cationic polymer which has high transfection efficiency due to its buffering effect. However, nondegradability, cytotoxicity, aggregation, and short-circulation time in vivo still need be overcome for successful gene delivery. Degradable, hyperbranched poly(ester amine)s (PEAs) based on poloxamer diacrylate low molecular weight branched PEI, were successfully synthesized evaluated as nonviral carrier. The PEAs obtained significant yields through Michael...
Degradable and hyperbranched poly (ester amine)s (PEAs) were successfully synthesized by Michael addition reaction between hydrophilic glycerol triacrylate (GTA) low-molecular-weight polyethylenimine (LMW-PEI) evaluated as nonviral gene carriers. PEAs effectively condensed DNA with particle sizes below 200 nm suitable surface charges (15-45 mV), for intracellular delivery. degraded in a controlled fashion showing half-lives of more than 12 days essentially nontoxic three different cell...