A5068982543- Nanoparticles: synthesis and applications
- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- Estrogen and related hormone effects
- Heavy Metal Exposure and Toxicity
- Nanoparticle-Based Drug Delivery
- Nuclear reactor physics and engineering
- Air Quality and Health Impacts
- Healthcare and Environmental Waste Management
- Inhalation and Respiratory Drug Delivery
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Glutathione Transferases and Polymorphisms
- Animal testing and alternatives
- Berberine and alkaloids research
- Drug-Induced Hepatotoxicity and Protection
- Nuclear Engineering Thermal-Hydraulics
- Cancer, Stress, Anesthesia, and Immune Response
- Building Energy and Comfort Optimization
- Pharmacogenetics and Drug Metabolism
- Graphene and Nanomaterials Applications
- Allelopathy and phytotoxic interactions
- AI in cancer detection
- Cancer Cells and Metastasis
Inha University
2020-2024
Hoseo University
2010-2024
Rural Development Administration
2014
National Academy of Agricultural Science
2014
Gachon University
2014
Korea Institute of Nuclear Safety
2012
Ministry of Food and Drug Safety
1997-2010
National Institute of Food and Drug Safety Evaluation
1994-2010
United States Food and Drug Administration
2009
Korea Institute of Toxicology
2003-2008
The antibacterial effect of silver nanoparticles has resulted in their extensive application health, electronic, and home products. However, while the population exposed to continues increase with ever new applications, remain a controversial research area as regards toxicity biological systems. In particular, oral is particular concern ensure public consumer health. Accordingly, this study tested (60 nm) over period 28 days Sprague-Dawley rats following Organization for Economic Cooperation...
The subchronic inhalation toxicity of silver nanoparticles was studied in Sprague-Dawley rats. Eight-week-old rats, weighing approximately 253.2 g (males) and 162.6 (females), were divided into four groups (10 rats each group): fresh-air control, low dose (0.6 × 106 particle/cm3, 49 μg/m3), middle (1.4 133 high (3.0 515 μg/m3). animals exposed to (average diameter 18–19 nm) for 6 h/day, 5 days/week, 13 weeks a whole-body chamber. In addition mortality clinical observations, body weight, food...
The antibacterial effect of silver nanoparticles has resulted in their extensive application health, electronic, and home products. Thus, the exposed population continues to increase as applications expand. Although previous studies on dust, fumes, compounds have revealed some insights, little is yet known about toxicity nano-sized particles, where size surface area are recognized important determinants for toxicity. inhalation particular concern ensure health workers consumers. However,...
The antimicrobial activity of silver nanoparticles has resulted in their widespread use many consumer products. However, despite the continuing increase population exposed to nanoparticles, effects prolonged exposure have not been thoroughly determined. Accordingly, this study attempted investigate inflammatory responses and pulmonary function changes rats during 90 days inhalation nanoparticles. were (18 nm diameter) at concentrations 0.7 x 10(6) particles/cm(3) (low dose), 1.4 particles...
Abstract Background Gold nanoparticles are widely used in consumer products, including cosmetics, food packaging, beverages, toothpaste, automobiles, and lubricants. With this increase products containing gold nanoparticles, the potential for worker exposure to will also increase. Only a few studies have produced data on vivo toxicology of meaning that absorption, distribution, metabolism, excretion (ADME) remain unclear. Results The toxicity was studied Sprague Dawley rats by inhalation....
Abstract: Nanoparticles (NPs) are used commercially in health and fitness fields, but information about the toxicity mechanisms underlying toxic effects of NPs is still very limited. The aim this study to investigate effect(s) 100 nm negatively (ZnO AE100[-] ) or positively AE100[+] charged zinc oxide (ZnO) administered by gavage Sprague Dawley rats, establish a no observed adverse effect level, identify target organ(s). After verification primary particle size, morphology, hydrodynamic zeta...
Kyung Hee Jung, Sang Eun Kim, Han Gyeol Go, Yun Ji Lee, Min Seok Park, Soyeon Ko, Beom Han, Young-Chan Yoon, Ye Jin Cho, Pureunchowon Sang-Ho Kipyo Kim and Soon-Sun Hong. Biomolecules & Therapeutics -0001;0:. https://doi.org/10.4062/biomolther.2023.062
Pancreatic ductal adenocarcinoma (PDAC) exhibits a pronounced extracellular matrix (ECM)-rich response, which is produced by an excessive amount of transforming growth factor β (TGF-β), resulting in tumor progression and metastasis. In addition, TGF-β signaling contributes to rapidly acquired resistance incomplete response gemcitabine. Recently, selective inhibitors the pathway have shown promise PDAC treatment, particularly as option for augmenting responses chemotherapy. Here, we...
Abstract: This study was undertaken to investigate the potential toxicity and establish no observed adverse effect level (NOAEL) target organ(s) of negatively charged colloidal silica particles different sizes, ie, SiO 2 EN,20(-) (20 nm) or EN,100(-) (100 nm), administered by gavage in Sprague-Dawley rats. After verification physicochemical properties be tested, a preliminary dose range-finding 90-day repeated were conducted according Organisation for Economic Cooperation Development test...
The biphasic modifying effects of indole‐3‐carbinol (I3C), a naturally occurring constituent edible cruciferous vegetables, on the development glutathione S‐transferase placental form (GST‐P)‐positive liver cell foci were investigated by using medium‐term bioassay system and newborn rat hepatocarcinogenesis system. In Experiment 1, total 65 male Sprague‐Dawley (SD) rats divided into 5 groups. Animals given single intraperitoneal (i.p.) injection 200 mg/kg diethylnitrosamine (DEN) dissolved...
Noise or artifacts in an image, such as shadow artifacts, deteriorate the performance of state-of-the-art models for segmentation image. In this study, a novel saliency-based region detection and image (SRIS) model is proposed to overcome problem existence noise intensity inhomogeneity. Herein, adaptive level-set evolution protocol based on internal external functions designed eliminate initialization sensitivity, thereby making SRIS robust contour initialization. energy function, weight...
The inhibitory influence of ferulic acid (FA), a rice germ component, and its geranylated derivative 3-(4'-geranyloxy-3-methoxyphenyl)-2-propenoate (EGMP) on the post-initiation stage azoxymethane (AOM)-induced colon carcinogenesis was studied in male F344 rats given two s.c. injections AOM (15 mg / kg body weight) during week 1. Diets containing EGMP or FA at doses 0.1 0.2% were then fed for 3 weeks from 2 to 5, when animals sacrificed. numbers aberrant crypt foci (ACF) crypts (AC) per rat...