A5062603464- Hydrogen's biological and therapeutic effects
- Immune Response and Inflammation
- Dietary Effects on Health
- Dermatology and Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Inflammatory Biomarkers in Disease Prognosis
- Nanoparticles: synthesis and applications
- Cancer, Lipids, and Metabolism
- NF-κB Signaling Pathways
- FOXO transcription factor regulation
- Inflammation biomarkers and pathways
- Allergic Rhinitis and Sensitization
- Circadian rhythm and melatonin
- Medical and Biological Ozone Research
- Exercise and Physiological Responses
- Chemokine receptors and signaling
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Therapeutic Uses of Natural Elements
- Sepsis Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Neonatal and Maternal Infections
Yonsei University
2015-2024
Kobe Asahi Hospital
2024
Hallym University
2023
Konkuk University
2011-2015
Yong In University
2011-2012
Konkuk University Medical Center
2012
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2006
Institute of Physiology and Basic Medicine
2006
Abstract: Nanoparticles (NPs) are used commercially in health and fitness fields, but information about the toxicity mechanisms underlying toxic effects of NPs is still very limited. The aim this study to investigate effect(s) 100 nm negatively (ZnO AE100[-] ) or positively AE100[+] charged zinc oxide (ZnO) administered by gavage Sprague Dawley rats, establish a no observed adverse effect level, identify target organ(s). After verification primary particle size, morphology, hydrodynamic zeta...
Abstract: While zinc oxide (ZnO) nanoparticles (NPs) have been recognized to promising applications in biomedicine, their immunotoxicity has inconsistent and even contradictory. To address this issue, we investigated whether ZnO NPs with different size (20 or 100 nm) electrostatic charge (positive negative) would cause vitro vivo, explored underlying molecular mechanism. Using Raw 264.7 cell line, examined the mechanism of as viability. We found that a viability assay, could induce...
Immunotoxicity of titanium dioxide nanoparticles via simultaneous induction apoptosis and multiple toll-like receptors signaling through ROS-dependent SAPK/JNK p38 MAPK activation Madhusmita Dhupal,1,2 Jae-Min Oh,3 Dipti Ranjan Tripathy,4 Soo-Ki Kim,2 Sang Baek Koh,5 Kyu-Sang Park6 1Department Global Medical Science, Wonju College Medicine, Yonsei University, Wonju, Republic Korea; 2Department Microbiology, 3Department Chemistry Chemistry, Science Technology, 4Department Neurology, Gauhati...
Abstract Paraquat (PQ) promotes cell senescence in brain tissue, which contributes to Parkinson's disease. Furthermore, PQ induces heart failure and oxidative damage, but it remains unknown whether how cardiac aging. Here, we demonstrate that phenotypes associated with of cardiomyocyte lines results aging‐associated including remodeling dysfunction vivo. Moreover, inhibits the activation Forkhead box O3 (FoxO3), an important longevity factor, both vitro We found PQ‐induced phenotypes,...
This study was performed to evaluate antifatigue effect of hydrogen water (HW) drinking in chronic forced exercise mice model.Twelve-week-old C57BL6 female were divided into nonstressed normal control (NC) group and stressed group: (purified water/PW-treated HW-treated group). Stressed groups supplied with PW HW, respectively, ad libitum swim for the stress induction every day 4 consecutive weeks. Gross effects HW assessed by swimming endurance capacity (once weekly wk), metabolic...
Abstract Patients with brain metastases (BM) can benefit from radiotherapy (RT), although the long-term benefits of RT remain unclear. We searched a Korean national health insurance claims database and identified 135,740 patients newly diagnosed BM during 2002–2017. Propensity score matching (PSM) was used to evaluate survival according modality, which included whole-brain (WBRT) and/or stereotactic radiosurgery (SRS). The 84,986 eligible were followed for median interval 6.6 months, 37,046...
Oxidative stress, characterized by an imbalance between the levels of reactive oxygen species (ROS) and antioxidants, plays a critical role in cancer progression. However, prognostic significance antioxidant markers colorectal (CRC) remains unclear. This study aimed to evaluate expression tumor tissues investigate their association with clinicopathological features, survival, systemic inflammation. We retrospectively analyzed 70 patients CRC who underwent curative surgical resection. The...
As fullerene‐based compound applications have been rapidly increasing in the health industry, need of biomedical research is urgently demand. While shungite regarded as a natural source fullerene, it remains poorly documented. Here, we explored vivo effects against ultraviolet B‐ (UVB‐) induced skin damage by investigating physiological parameters, immune‐redox profiling, and oxidative stress molecular signaling. Toward this, mice were UVB‐irradiated with 0.75 mW/cm 2 for two consecutive...
Atopic dermatitis (AD) is a chronic relapsing allergic inflammatory skin disease that currently affects millions of children and adults worldwide. Drugs used to treat these diseases include anti-histamines, corticosteroids calcineurin inhibitors but drugs have their limitations such as adverse effects with long-term usage. Thus, researcher's interest in several alternative complementary therapies are continually growing balneotherapy one approaches. Therefore, we investigate the bathing...
The tumor microenvironment of colorectal cancer (CRC) is heterogenous; thus, it likely that multiple immune-related and inflammatory markers are simultaneously expressed in the tumor. aim this study was to identify freshly frozen CRC tissues investigate whether they related clinicopathological features prognosis CRC. Seventy patients with who underwent curative surgical resection between December 2014 January 2017 were included study. Tissue samples obtained from non-tumor areas patients'...
Summary Toll‐like receptors (TLRs) are pattern recognition (PRRs) that recognize conserved pathogen‐associated molecular patterns (PAMPs) synthesized by micro‐organisms. Despite the essential requirement for TLRs in prokaryotic infection, and regulation of TLR gene expression Trichomonas vaginalis mucocutaneous barrier still unknown. Our hypothesis is T. ‐infected epithelial cells major effector skin barrier. These function as a central regulator expression, thus accelerating process...
The macrophage-derived chemokine (MDC/CCL22) is a prototypic Th2-type intimately involved in Th2-skewed allergic diseases, such as atopic dermatitis and asthma. statins (3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitors) have been demonstrated to relieve inflammation. However, the immunological effects mechanisms of against remain unknown, at least vitro. This study aimed define how different affect MDC expression HaCaT cells, human keratinocyte cell line.To measure on we used...
Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying allergic inflammation. AD triggered by oxidative stress and immune imbalance. In the present study, we investigated effect of drinking hydrogen water (HW) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic in NC/Nga mice found that HW ameliorated DNCB-induced AD-like clinical symptoms. line with this, level reactive oxygen species group was significantly inhibited compared purified (PW) group....
Acidic electrolyzed water is an innovative sanitizer having a wide-spectrum of applications in food industry, and healthcare industry but little known on its effect mechanism wound healing. The study was conducted to identify the slightly acidic (SAEW) cutaneous wounds hairless mice. SAEW (pH: 5–6.5, oxidation reduction potential: 800 mV, chlorine concentration: 25 ppm) prepared through electrolysis applied mice three times day for seven days. Wound size, immune response oxidative stress...
Strong acidic electrolyzed water (StAEW) is known to inactivate microorganisms but not fully explored in the medical field. This study aimed at exploring StAEW as a potential wound care agent and its mechanism. (pH: 2.65, ORP: 1159 mV, ACC: 32.1 ppm) was sprayed three times day cutaneous wounds of hairless mice for seven days. Wound morphological histological features immune-redox markers were compared with saline- (Sal-) alcohol- (Alc-) treated groups. Results showed that group...