A5032561728- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nanoparticles: synthesis and applications
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Air Quality and Health Impacts
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Healthcare and Environmental Waste Management
- Cancer Genomics and Diagnostics
- Cancer therapeutics and mechanisms
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Lymphoma Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Catalytic Processes in Materials Science
- Hepatocellular Carcinoma Treatment and Prognosis
- Viral-associated cancers and disorders
- Cancer Treatment and Pharmacology
- Aerosol Filtration and Electrostatic Precipitation
- Heavy Metal Exposure and Toxicity
Sungkyunkwan University
2016-2025
Samsung (South Korea)
2016-2025
The University of Texas Southwestern Medical Center
2025
Yonsei University
2001-2024
Boramae Medical Center
2024
AstraZeneca (United States)
2024
AstraZeneca (United Kingdom)
2024
Samsung Changwon Hospital
2013-2023
Samsung Medical Center
2012-2023
Cedars-Sinai Medical Center
2023
The subchronic inhalation toxicity of silver nanoparticles was studied in Sprague-Dawley rats. Eight-week-old rats, weighing approximately 253.2 g (males) and 162.6 (females), were divided into four groups (10 rats each group): fresh-air control, low dose (0.6 × 106 particle/cm3, 49 μg/m3), middle (1.4 133 high (3.0 515 μg/m3). animals exposed to (average diameter 18–19 nm) for 6 h/day, 5 days/week, 13 weeks a whole-body chamber. In addition mortality clinical observations, body weight, food...
The antibacterial effect of silver nanoparticles has resulted in their extensive application health, electronic, and home products. Thus, the exposed population continues to increase as applications expand. Although previous studies on dust, fumes, compounds have revealed some insights, little is yet known about toxicity nano-sized particles, where size surface area are recognized important determinants for toxicity. inhalation particular concern ensure health workers consumers. However,...
The antimicrobial activity of silver nanoparticles has resulted in their widespread use many consumer products. However, despite the continuing increase population exposed to nanoparticles, effects prolonged exposure have not been thoroughly determined. Accordingly, this study attempted investigate inflammatory responses and pulmonary function changes rats during 90 days inhalation nanoparticles. were (18 nm diameter) at concentrations 0.7 x 10(6) particles/cm(3) (low dose), 1.4 particles...
With the increased production and widespread use of multiwalled carbon nanotubes (MWCNTs), human environmental exposure to MWCNTs is inevitably increasing. Therefore, this study monitored possible MWCNT release in a nanotube research laboratory. To estimate potential researchers evaluate improvement workplace environment after implementation protective control measures, personal area monitoring were conducted an facility where handled unrefined materials. The number, composition, aspect...
Adjuvant chemotherapy and chemoradiotherapy are some of the standards care for gastric cancer (GC). The chemoRadioTherapy In Stomach Tumors (ARTIST) 2 trial compares two adjuvant regimens in patients with D2-resected, stage II or III, node-positive GC.The ARTIST compared, a 1:1:1 ratio, three regimens: oral S-1 (40-60 mg twice daily 4 weeks on/2 off) 1 year, (2 on/1 week plus oxaliplatin 130 mg/m2 every 3 (SOX) 6 months, SOX 45 Gy (SOXRT). Randomization was stratified according to surgery...
In the phase III CASPIAN study, first-line durvalumab in combination with etoposide plus either cisplatin or carboplatin (EP) significantly improved overall survival (OS) versus EP alone extensive-stage small-cell lung cancer (ES-SCLC). Durvalumab tremelimumab numerically OS EP, but did not reach statistical significance. Here we report updated censored patients after median follow-up of >3 years.805 treatment-naïve ES-SCLC were randomized 1 : to EP. The two primary endpoints for and EP.As...
Abstract The VIKTORY (targeted agent eValuation In gastric cancer basket KORea) trial was designed to classify patients with metastatic based on clinical sequencing and focused eight different biomarker groups (RAS aberration, TP53 mutation, PIK3CA mutation/amplification, MET amplification, overexpression, all negative, TSC2 deficient, or RICTOR amplification) assign one of the 10 associated trials in second-line (2L) treatment. Capivasertib (AKT inhibitor), savolitinib (MET selumetinib (MEK...
Abstract Background Gold nanoparticles are widely used in consumer products, including cosmetics, food packaging, beverages, toothpaste, automobiles, and lubricants. With this increase products containing gold nanoparticles, the potential for worker exposure to will also increase. Only a few studies have produced data on vivo toxicology of meaning that absorption, distribution, metabolism, excretion (ADME) remain unclear. Results The toxicity was studied Sprague Dawley rats by inhalation....
Seven CNT (carbon nanotube) handling workplaces were investigated for exposure assessment. Personal sampling, area and real-time monitoring using an SMPS (scanning mobility particle sizer), dust monitor, aethalometer performed to characterize the mass exposure, size distribution, number exposure. No workplace was found exceed current ACGIH (American Conference of Governmental Industrial Hygienists) TLVs (threshold limit values) OELs (occupational levels) set by Korean Ministry Labor carbon...
Objectives: The antimicrobial activity of silver nanoparticles has resulted in their widespread use many consumer products. Yet, despite advantages, it is also important to determine whether may represent a hazard the environment and human health. Methods: Thus, evaluate genotoxic potential nanoparticles, vivo genotoxicity testing (OECD 474, micronuclei test) was conducted after exposing male female Sprague-Dawley rats by inhalation for 90 days according OECD test guideline 413 (Subchronic...
With the increased production and widespread use of nanomaterials, human environmental exposure to nanomaterials is inevitably increasing. Therefore, this study monitored possible nanoparticles at workplaces that manufacture nano-TiO2 nano-silver. To estimate potential workers, personal sampling, area monitoring, real-time monitoring using a scanning mobility particle sizer (SMPS) dust monitor were conducted where workers handle nanomaterials. The gravimetric concentrations TiO2 ranged from...
The genetic landscape of medullary thyroid cancer (MTC) is not yet fully understood, although some oncogenic mutations have been identified. To explore profiles MTCs, formalin-fixed, paraffin-embedded tumor tissues from MTC patients were assayed on the Ion AmpliSeq Cancer Panel v2. Eighty-four sporadic samples and 36 paired normal successfully sequenced. We discovered 101 hotspot in 18 genes 84 tissue samples. most common mutation was ret proto-oncogene, which occurred 47 cases followed by...
In the CASPIAN trial, first-line durvalumab plus platinum-etoposide (EP) significantly improved overall survival (OS) versus EP alone in extensive-stage small cell lung cancer (ES-SCLC). We report exploratory analyses of outcomes by programmed death ligand-1 (PD-L1) expression and tissue tumor mutational burden (tTMB).
In a previous study, the lung function, as indicated by tidal volume, minute and peak inspiration flow, decreased during 90 days of exposure to silver nanoparticles was accompanied inflammatory lesions in morphology. Therefore, this study investigated recovery from such function changes rats following cessation 12 weeks nanoparticle exposure. Male female were exposed (14–15 nm diameter) at concentrations 0.66 × 106 particles/cm3 (49 μg/m3, low dose), 1.41 (117 middle 3.24 (381 high dose) for...
The acute inhalation toxicity of silver nanoparticles was studied in Sprague-Dawley rats. Seven-week-old rats, weighing approximately 218 g (males) and 153 (females), were divided into four groups (five rats each group): fresh-air control, low-dose (0.94 × 10 6 particle/cm 3 , 76 µg/m ), middle-dose (1.64 particle/ cm 135 high-dose (3.08 750 ). animals then exposed to (average diameter 18-20 nm) for 4 hours a whole-body chamber. experiment conducted following Organization Economic...
4001 Background: Adjuvant chemotherapy and/or chemoradiotherapy have been the standard of care in GC for years, supported by randomized trials. We compared efficacy different regimens and patients with D2-resected, stage II/III, node-positive GC. Methods: From Feb 2013 through Nov 2018, we randomly assigned, a 1:1:1 ratio, pathologically-staged II or III, node-positive, D2-resected GC, to receive adjuvant S-1 (40-60 mg twice daily 4-weeks-on/2-weeks-off) one year, (2-weeks-on/1-week-off)...
The role of chemotherapy in adenoid cystic carcinoma (ACC) is controversial because ACC usually stable without and the lack randomized trials. Here, we conducted first trial to evaluate efficacy axitinib as compared with observation ACC.In this multicenter, prospective phase II trial, enrolled patients recurrent or metastatic whose cancer had progressed within past 9 months. Patients were randomly assigned either (5 mg twice daily) at a 1:1 ratio. Crossover from was permitted after...
In the phase 3 study involving use of durvalumab with or without tremelimumab in combination platinum-based chemotherapy untreated extensive-stage SCLC (CASPIAN study), first-line plus platinum-etoposide (EP) significantly improved overall survival (OS) versus EP alone (p = 0.0047). We report exploratory subgroup analyses treatment patterns and outcomes according to presence baseline brain central nervous system metastases.Patients (WHO performance status 0 1), including those asymptomatic...