A5046672787- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Cancer survivorship and care
- Esophageal Cancer Research and Treatment
- Angiogenesis and VEGF in Cancer
- Enhanced Recovery After Surgery
- Chemokine receptors and signaling
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphatic System and Diseases
- Neuroendocrine Tumor Research Advances
- Abdominal Surgery and Complications
- Minimally Invasive Surgical Techniques
- Cytokine Signaling Pathways and Interactions
- Suicide and Self-Harm Studies
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- RNA Interference and Gene Delivery
Samsung Medical Center
2008-2024
Sungkyunkwan University
2010-2024
National Cancer Center
2003-2013
Samsung (United States)
2011
Dongguk University
2008
National Cancer Research Institute
2007
National Cancer Center
2004
Seoul National University
1994
The purpose of this study was to evaluate the quality life (QOL) after laparoscopy-assisted distal gastrectomy (LADG) compared with open (ODG) in patients early gastric cancer.LADG has been beneficial terms pain, recovery, and morbidity when surgery equal oncologic outcome. There no clinical on QOL.From July 2003 November 2005, 164 newly diagnosed cT1N0M0 cT1N1M0 cancer were randomly assigned either LADG or ODG. All asked complete European Organization for Research Treatment Cancer QLQ-C30...
BackgroundTo identify predictive markers for responders in lapatinib-treated patients and to demonstrate molecular changes during lapatinib treatment via cell-free genomics.Patients methodsWe prospectively evaluated the efficacy of combining with capecitabine oxaliplatin as first line neoadjuvant therapy previously untreated, HER2-overexpressing advanced gastric cancer. A parallel biomarker study was conducted by simultaneously performing immunohistochemistry next-generation sequencing (NGS)...
4001 Background: Adjuvant chemotherapy and/or chemoradiotherapy have been the standard of care in GC for years, supported by randomized trials. We compared efficacy different regimens and patients with D2-resected, stage II/III, node-positive GC. Methods: From Feb 2013 through Nov 2018, we randomly assigned, a 1:1:1 ratio, pathologically-staged II or III, node-positive, D2-resected GC, to receive adjuvant S-1 (40-60 mg twice daily 4-weeks-on/2-weeks-off) one year, (2-weeks-on/1-week-off)...
Biomarkers are needed for noninvasive early detection of gastric cancer (GC). We investigated salivary extracellular RNA (exRNA) biomarkers as potential clinical evaluation tools GC.Unstimulated whole saliva samples were prospectively collected from 294 individuals (163 GC and 131 non-GC patients) who underwent endoscopic at the Samsung Medical Center in Korea. Salivary transcriptomes 63 31 patients profiled, mRNA biomarker candidates verified with reverse transcription quantitative...
Docetaxel (T) and capecitabine (X) are active agents against gastric cancer with synergistic antitumor effects. We conducted the current phase II study to assess response rate toxicity of combination TX regimen in patients metastatic cancer. Eligible were treated docetaxel (36 mg/m2 intravenously) on days 1 8 (1000 orally twice a day) 1–14 3-week schedule until progression occurred. From December 2001 May 2003, 55 median age 54 years (range, 22–73 years) enrolled; 47 had measurable lesions....
In Brief Objectives: There is increasing evidence that chemokines and chemokine receptors are causally involved in the metastasis of cancer. Little known about possible role gastric The aim this study was to investigate expression their prognostic patients with Methods: We screened CCR CXCR 12 cancer cell lines using semi-quantitative RT-PCR. CCR4, one most commonly expressed chemokines, confirmed Western blot flow cytometry analysis 8 lines. function CCR4 examined migration proliferation...
Abstract To gain insight into clinically relevant mechanisms of irinotecan resistance, we undertook oligonucleotide microarray analyses on paired malignant effusion samples obtained from eight gastric cancer patients treated with weekly irinotecan. Pretreatment and posttreatment (48 h) were for each patient, the change in expression profile was compared between clinical responders nonresponders. When differences genes examined using SAM (Significance Analysis Microarrays) software, five...
In several recent reports, docetaxel (75-85 mg/m2) combined with fluorouracil (5-FU) and cisplatin has shown considerable efficacy but significant toxicities, especially neutropenia, in patients advanced gastric cancer. The authors tested the safety of a lower dose (50 docetaxel, 5-FU cisplatin, metastatic cancer (MGC).Chemonaive MGC received mg/m2 on day 1), (80 (1200 days 1-3) every 21 days.Forty-seven median age 55 years (range, 30-73 years) 4 cycles 1-13+ cycles). Of 42...
We evaluated the learning curve and short-term surgical outcomes of robot-assisted distal gastrectomy (RADG) performed by a single surgeon experienced in open, but not laparoscopic, gastrectomy. aimed to verify feasibility performing RADG without extensive laparoscopic experience.Between July 2012 December 2016, 60 procedures were using da Vinci® Surgical System (Intuitive Surgical). Patient characteristics, length curve, parameters, postoperative analyzed compared before after had been...