A5100780593- Electrohydrodynamics and Fluid Dynamics
- Thin-Film Transistor Technologies
- Particle Dynamics in Fluid Flows
- Aerosol Filtration and Electrostatic Precipitation
- Asphalt Pavement Performance Evaluation
- Surface Roughness and Optical Measurements
- Infrastructure Maintenance and Monitoring
- Semiconductor Lasers and Optical Devices
- Mass Spectrometry Techniques and Applications
- Catalytic Processes in Materials Science
- Cyclone Separators and Fluid Dynamics
- Organic Light-Emitting Diodes Research
- Color Science and Applications
- Silicon Nanostructures and Photoluminescence
- Advanced Optical Imaging Technologies
- Bone Tissue Engineering Materials
- Engineering Applied Research
- Silicon and Solar Cell Technologies
- nanoparticles nucleation surface interactions
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Industrial Gas Emission Control
- Coagulation and Flocculation Studies
- Air Quality and Health Impacts
Georgetown University
2006-2024
Samsung (South Korea)
2001-2024
Allogene Therapeutics (United States)
2017-2024
Georgetown University Medical Center
2006-2024
George Washington University
2023
Sungkyunkwan University
2018-2022
University of Akron
2022
Biomedical Research Institute
2021
Pusan National University Hospital
2021
National Institute of Fisheries Science
2021
The antibacterial effect of silver nanoparticles has resulted in their extensive application health, electronic, and home products. Thus, the exposed population continues to increase as applications expand. Although previous studies on dust, fumes, compounds have revealed some insights, little is yet known about toxicity nano-sized particles, where size surface area are recognized important determinants for toxicity. inhalation particular concern ensure health workers consumers. However,...
Abstract We have established a method for systematic integration of multiple microarray datasets. The was applied to two different sets cancer profiling studies. change gene expression in expressed as ’ effect size’, standardized index measuring the magnitude treatment or covariate effect. sizes were combined obtain estimate overall mean. statistical significance determined by permutation test extended It shown that data promotes discovery small but consistent changes with increased...
For the realization of high-efficiency flexible optoelectronic devices, transparent electrodes should be fabricated through a low-temperature process and have crucial feature low surface roughness. In this paper, we demonstrated two-step spray-coating method for producing large-scale, smooth silver nanowire (AgNW)–poly3,4-ethylenedioxythiophene:polystyrenesulfonate (PEDOT:PSS) composite electrodes. Without high-temperature annealing process, conductivity film was improved via lamination...
Abstract The world's largest (15‐inch) XGA active matrix liquid crystal display (AMLCD) panel made with IGZO TFTs (W/L=29.5/4 μm) was fabricated and evaluated the field effective mobility of 4.2±0.4 cm 2 /V‐s, V th −1.3±1.4V sub‐threshold swing (SS) 0.96±0.10 V/dec. for a manufacturing‐oriented process, main factors affecting threshold voltage (V ) thin film transistors (TFT) are investigated. On glass surface, thicker regions have negative shift. A dry etching process molybdenum source...
In Brief Objective: The objective of this study is to investigate if bone marrow–derived cells (BMCs) regenerate vascular tissues and improve patency in tissue-engineered small-diameter (internal diameter = 3 mm) grafts. Summary Background Data: BMCs have demonstrated the ability differentiate into endothelial-like smooth muscle–like may offer an alternative cell source for tissue engineering. Thus, we grafts with decellularized arteries. Methods: Canine were differentiated vitro muscle...
RNA interference (RNAi)–mediated knockdown of gene expression offers a novel treatment strategy for human immunodeficiency virus (HIV) infection. However, the major hurdle clinical use is practical small interfering (siRNA) delivery to multiple immune cell types important in viral pathogenesis. We have developed immunoliposome method targeting lymphocyte function–associated antigen-1 (LFA-1) integrin expressed on all leukocytes and evaluated it systemic siRNA humanized mouse model. show that...
Inflammation mediated by tumor necrosis factor-alpha (TNF-alpha) and the associated neuronal apoptosis characterizes a number of neurologic disorders. Macrophages microglial cells are believed to be major source TNF-alpha in central nervous system (CNS). Here, we show that suppression targeted delivery small interfering RNA (siRNA) macrophage/microglial dramatically reduces lipopolysaccharide (LPS)-induced neuroinflammation vivo. Because macrophage/microglia express nicotinic acetylcholine...
Temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) has been linked to upregulation of O(6)-methylguanine-DNA methyltransferase (MGMT). Wild-type (wt) p53 was previously shown down-modulate MGMT. However, therapy for GBM is limited by lack efficient delivery across the blood brain barrier (BBB). We have developed a systemic nanodelivery platform (scL) tumor-specific targeting (primary and metastatic), which currently multiple clinical trials. This self-assembling nanocomplex...
This paper describes a method of estimating irregularities in railway tracks using acceleration data measured from high-speed trains. Track are the main causes vibration trains and thus should be carefully monitored to maintain stability ride quality A mixed filtering approach is proposed for stable displacement estimation waveband classification acceleration. Accelerometers mounted on axle box bogie train measure lateral vertical directions. The estimated results compared with those...
Abstract— Amorphous‐oxide thin‐film‐transistor (TFT) arrays have been developed as TFT backplanes for large‐sized active‐matrix organic light‐emitting‐diode (AMOLED) displays. An amorphous‐IGZO (indium gallium zinc oxide) bottom‐gate with an etch‐stop layer (ESL) delivered excel lent electrical performance a field‐effect mobility of 21 cm 2 /V‐sec, on/off ratio >10 8 , and subthreshold slope (SS) 0.29 V/dec. Also, new pixel circuit AMOLED displays based on amorphous‐oxide semiconductor...
Intrinsic therapeutic resistance especially in cancer stem cells (CSCs) together with extensive tumor cell infiltration and restricted permeation of the blood-brain barrier (BBB) by drugs may all contribute to treatment failure patients glioblastoma multiforme (GBM). Accumulating evidence suggests that long non-coding RNA (lncRNA), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a role GBM. Using our tumor-targeted nanocomplex, we have modulated expression MALAT1...
Abstract Biodegradable polymer/ceramic scaffolds can overcome the limitations of conventional ceramic bone substitutes. However, methods scaffold fabrication often use organic solvents, which might be harmful to cells or tissues. Moreover, fabricated with have limited exposure on surface since polymer solution envelopes particles during process. In this study, we developed a novel method for efficient onto surface, would enhance osteoconductivity and wettability scaffold. Poly( D , L...
Although biodegradable polymer/ceramic composite scaffolds can overcome the limitations of conventional ceramic bone substitutes, osteogenic potential these needs to be further enhanced for efficient tissue engineering. In this study, bonelike apatite was efficiently coated onto scaffold surface by using instead polymer and an accelerated biomimetic process enhance scaffold. The creation bonelike, apatite-coated achieved incubating in simulated body fluid (SBF). growth on porous...