A5052985063- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Cancer survivorship and care
- Cancer Treatment and Pharmacology
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Metastasis and carcinoma case studies
- Cancer Risks and Factors
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Sarcoma Diagnosis and Treatment
- Health and Wellbeing Research
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
Izmir Kâtip Çelebi University
2016-2025
Ministry of Health of the Russian Federation
2024
Weatherford College
2023
Izmir Atatürk Eğitim ve Araştırma Hastanesi
2014-2019
Center for Rheumatology
2019
Izmir University
2009-2018
Dokuz Eylül University
2004-2016
Izmir Bozyaka Eğitim ve Araştırma Hastanesi
2009-2016
Selçuk University
2016
Ministry of Health
2015
In the phase III IMpassion130 trial, combining atezolizumab with first-line nanoparticle albumin-bound-paclitaxel for advanced triple-negative breast cancer (aTNBC) showed a statistically significant progression-free survival (PFS) benefit in intention-to-treat (ITT) and programmed death-ligand 1 (PD-L1)-positive populations, clinically meaningful overall (OS) effect PD-L1-positive aTNBC. The KEYNOTE-355 trial adding pembrolizumab to chemotherapy aTNBC similar PFS effects. IMpassion131...
PURPOSE To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor–positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455 ). METHODS Post-/pre-/perimenopausal women, or men, age 18 years older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly...
Abstract Purpose : Burnout is associated with decreased job performance and commitment, predicts stress‐related health problems, low career satisfaction. The specific objectives in our study were to assess the levels of burnout investigate interrelationships between demographic characteristics health‐care professionals working cancer patients Turkey. Methods A questionnaire‐based was conducted 77 physicians 56 nurses an oncology clinic at university hospital. We used quantitative survey...
PURPOSE Fibroblast growth factor receptor 2 isoform IIIb (FGFR2b) protein overexpression is an emerging biomarker in gastric cancer and gastroesophageal junction (GC). We assessed FGFR2b prevalence nearly 3,800 tumor samples as part of the prescreening process for a global phase III study patients with newly diagnosed advanced or metastatic GC. METHODS As June 28, 2024, 3,782 from prescreened 37 countries FORTITUDE-101 trial (ClinicalTrials.gov identifier: NCT05052801) were centrally tested...
Objective The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score the Geriatric Nutrition Risk Index (GNRI) are used as prognostic factors in different types of cancers. In this study we analyzed value HALP GNRI calculated prior to first-line treatment patients diagnosed with de novo metastatic non-small cell lung cancer (mNSCLC). Materials methods De mNSCLC were retrospectively evaluated from January 2016 December 2019. Patients Driver’s mutation, severe comorbidities, active...
<b><i>Background:</i></b> Several studies evaluating the prognostic factors of gastrointestinal and pancreatic neuroendocrine tumors (GEP-NETs) have been published. The neutrophil-lymphocyte ratio (NLR) platelet-lymphocyte (PLR) accepted as for cancer patients. <b><i>Materials Methods:</i></b> This study included 132 patients diagnosed with GEP-NETs. Peripheral blood samples were collected before pretreatment period....
The aim of the current study are to determine depression levels adult oncology patients in cancer treatment phase and identify both cancer-related stigma factors affecting their levels.In this correlational study, 303 who had been treated at a medical outpatient clinic were surveyed using convenience sampling method. "questionnaire for measuring attitudes toward - patient version," sociodemographic characteristics questionnaire, beck inventory used. A multivariable linear regression model...
We aimed to investigate anxiety, depression and sexual satisfaction levels the effects of anxiety upon Turkish breast cancer patients their partners.Data were collected from one hundred partners, using three forms: covering information about socio-demographic characteristics patients, Hospital Anxiety Depression Scale (HADs) Golombok-Rust Inventory Sexual Satisfaction (GRISS).The frequencies, avoidance touch subscores statistically significantly high in patients. Among those with scores,...
To investigate the variables of quality life (QoL) among Turkish patients with colorectal cancer (CRC).In this prospective study we investigated QoL CRC patients. Two hundred and twenty two were included. The sociodemographic form European Organization for Research Treatment Cancer Quality Life Questionnaire (EORTC QLQ-C30) used.The group consisted 142 males (64%) 80 females (36%). mean patient age was 55.68±11.387 years. majority (36.9%) had local disease while advanced-stage locally...
Hepatocellular cancer (HCC) is one of the important health problems in Turkey. We aimed to determine clinical and demographic features HCC Turkish population evaluate prognostic survival features.Two hundred twenty-one patients with from five hospitals Turkey are included this study.In 44.4% 221 hepatitis B virus 21.3% C were found be responsible for etiology. It has been shown that developed on cirrhosis basis 74.2% patients. was presented single solitary nodule 69.2% Non-liver metastasis...
Objective Endothelial dysfunction is present in ankylosing spondylitis (AS). However, the etiology of events still unclear. The aim study was to investigate whether there are abnormalities nitric oxide (NO) metabolism and endothelin-1 (ET-1) AS patients. Methods Subjects without any classical cardiovascular (CV) risk factors were studied. Fasting glucose, serum lipids, high sensitive CRP (hsCRP), ESR, asymmetric dimethylarginine (ADMA) ET-1 Patients also evaluated with Bath Ankylosing...
Background: It is well known that tumor-infiltrating lymphocytes (TIL) and, to a lesser extent, peripheral hematologic parameters from patients with cancer have effect on prognosis. The aim of this study was evaluate the p
249 Background: Urotensin-II is a small somatostatin-like cyclic peptide characterized by its potent vasoconstrictor activity. (UT-II) and receptor (UTR) have been shown to play role in the formation of different epithelial cancers. To date, many studies reported prostate cancer that provide genetic contributions with diagnostic, prognostic therapeutic potential for carcinogenesis. However, urotensin-II carcinogenesis has not yet elucidated. There are several limitations using PSA as...
Amaç: Meme kanseri, kadınlar arasında en yaygın kanser türü olup, özellikle gelişmekte olan ülkelerde insidans ve mortalitesi artmaktadır. Tarama programları, hastalık belirtileri ortaya çıkmadan önce hastalığı tespit etmeyi amaçlar. Türkiye'de 40-69 yaş arası için iki yılda bir mamografi taraması önerilmektedir. Bu çalışmanın amacı, meme kanseri tanısı almış tedavileri tamamlanmış hastaların, tanı öncesinde aile hekimlerinden hizmeti alma durumlarını değerlendirmektir. Gereç Yöntemler:...
The cardiac toxicity of LV5FU2 (de Gramont) regimen which is a widely used chemotherapy in gastrointestinal system cancers not well defined. We aimed to evaluate the impact this on rhythm. Two Holter ECG recordings were obtained all patients with treated as first-line (one before and second during first 24 h chemotherapy). Records reviewed for heart rate, rhythm, atrial premature complexes (APC), ventricular (VPC), grades according Lown-Wolf grading ST segment changes. evaluated 27 patients....
Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Mediators such as macrophage migration inhibitory factor (MIF) interleukin-10 (IL-10) are thought to be involved in several conditions, including AS. Proinflammatory cytokines regulate production of oxidative stress markers, nitric oxide (NO) malondialdehyde (MDA). Although lipid peroxidation have been reported AS, association AS with commonly known markers remains uncertain. We...