A5027075905- Galectins and Cancer Biology
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Glycosylation and Glycoproteins Research
- Advanced Breast Cancer Therapies
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Toxin Mechanisms and Immunotoxins
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Breast Lesions and Carcinomas
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Lung Cancer Research Studies
- Cancer Risks and Factors
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
University of Chieti-Pescara
2012-2021
Ospedale SS. Annunziata
2016-2021
Kliniken Essen-Mitte
2021
University of L'Aquila
2006-2019
Presidio Ospedaliero
2017-2019
University of Trieste
2017-2019
Azienda Socio Sanitaria Territoriale Lariana
2019
Santissima Trinità
2018
Azienda Ospedaliera Sant'Andrea
2017
Ospedale Policlinico San Martino
2017
In the phase III IMpassion130 trial, combining atezolizumab with first-line nanoparticle albumin-bound-paclitaxel for advanced triple-negative breast cancer (aTNBC) showed a statistically significant progression-free survival (PFS) benefit in intention-to-treat (ITT) and programmed death-ligand 1 (PD-L1)-positive populations, clinically meaningful overall (OS) effect PD-L1-positive aTNBC. The KEYNOTE-355 trial adding pembrolizumab to chemotherapy aTNBC similar PFS effects. IMpassion131...
The aim of our study was to characterize a model human prostaglandin endoperoxide synthase-2 (PGHS-2) expression allowing the assessment pharmacological inhibition in vitro and ex vivo. Heparinized whole blood samples were incubated with lipopolysaccharide (LPS, 0.1-50 micrograms/ml) for 0 24 hr at 37 degrees C. contribution platelet PGHS-1 suppressed by either pretreating subjects aspirin (300 mg 48 before sampling) or adding (10 time 0. PGE2 measured radioimmunoassay. LPS induced...
<h3>Background</h3> Recent evidence suggested a potential correlation between overweight and the efficacy of immune checkpoint inhibitors (ICIs) in cancer patients. <h3>Patients methods</h3> We conducted retrospective study advanced patients consecutively treated with anti-PD-1/PD-L1 inhibitors, order to compare clinical outcomes according baseline BMI levels as primary analysis. Based on their BMI, were categorized into overweight/obese (≥ 25) non-overweight (< 25). A gender analysis was...
The immune system seems to play a fundamental role in breast cancer responsiveness chemotherapy. We investigated two peripheral indicators of immunity/inflammation, i.e. neutrophil lymphocyte ratio (NLR) and platelet (PLR), order reveal possible relationship with pathological complete response (pCR) patients early or locally advanced treated neoadjuvant chemotherapy (NACT).We retrospectively analyzed 373 consecutive affected by candidates NACT. blood cell count before starting NACT was...
Galectin-3 is a carbohydrate-binding protein endowed with affinity for beta-galactosides. It plays role in cell-cell and cell-matrix interactions. Furthermore, it has been hypothesized to be involved tumor progression metastasis. To address the of galectin-3 invasive metastatic processes, we stably overexpressed human breast carcinoma cell lines, evaluated influence elevated expression on several features, including cellular homotypic heterotypic interactions survival. No differences various...
Immunization of mice with conditioned media from human breast cancer cells yielded the monoclonal antibody SP-2, which recognized an antigen approximately 9&95 kDa.This protein, designated 90K, was found to be present in serum healthy individuals and at elevated levels subpopulations patients various types AIDS.Here we report primary structure SP-2 demonstrate its relationship a family proteins carry scavenger receptor cysteine-rich domain.Northern blot analysis normal tissues, tumors,...
// Francesco Passiglia 1, * , Giuseppe Bronte Viviana Bazan Clara Natoli 2 Sergio Rizzo 1 Antonio Galvano Angela Listì Cicero Christian Rolfo 3 Daniele Santini 4 Russo Section of Medical Oncology, Department Surgical, Oncological and Oral Sciences, University Palermo, Italy Medical, Biotechnological "G. D'Annunzio", Chieti, Phase I- Early Clinical Trials Unit, Oncology Multidisciplinary Center Antwerp (MOCA), Hospital, Edegem, Belgium Department, Campus Biomedico, Rome, These authors have...
Galectins are a family of proteins involved in several cell processes, including their survival and death. Galectin-3 has particular been described as an anti-apoptotic molecule entangled with number subcellular activities anoikis resistance. In this work we partially address the mechanisms underlying activity pointing at two key factors injury progression: alteration mitochondrial membrane potential formation reactive oxygen species. Overexpression galectin-3 appears fact to exert...
The present study investigated the efficacy and safety of nivolumab in pre-treated patients with advanced NSCLC harbouring KRAS mutations.Clinical data mutational status were analysed treated within Italian Expanded Access Program. Objective response rate, progression-free survival overall evaluated. Patients monitored for adverse events using National Cancer Institute Common Terminology Criteria Adverse Events.Among 530 evaluated mutations, 206 (39%) positive while 324 (61%) wild-type...
Abstract Background HER2-targeting agents have dramatically changed the therapeutic landscape of HER2+ advanced breast cancer (ABC). Within a short time frame, rapid introduction new therapeutics has led to approval pertuzumab combined with trastuzumab and taxane in first-line, emtansine (T-DM1) second-line. Thereby, evidence T-DM1 efficacy following trastuzumab/pertuzumab combination is limited, data from some retrospective reports suggesting lower activity. The purpose present study...
// Patrizia Vici 1 , Laura Pizzuti Andrea Michelotti 2 Isabella Sperduti 3 Clara Natoli 4 Lucia Mentuccia 5 Luigi Di Lauro Domenico Sergi Paolo Marchetti 6 Daniele Santini 7 Emanuela Magnolfi Iezzi Luca Moscetti 8 Agnese Fabbri 9 Alessandra Cassano 10 Antonino Grassadonia Claudia Omarini 11 Federico Piacentini Botticelli Ilaria Bertolini Angelo Fedele Scinto 12 Germano Zampa 13 Maria Mauri 14 Loretta D'Onofrio Valentina Sini Maddalena Barba Marcello Maugeri-Saccà Ernesto Rossi Elisabetta...