A5032372555- Cervical Cancer and HPV Research
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Cancer survivorship and care
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Congenital Heart Disease Studies
- Lung Cancer Research Studies
- Estrogen and related hormone effects
- Lung Cancer Diagnosis and Treatment
- Global Public Health Policies and Epidemiology
- Transplantation: Methods and Outcomes
- Glioma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Cancer-related cognitive impairment studies
- Chronic Disease Management Strategies
- Interpreting and Communication in Healthcare
- Global Cancer Incidence and Screening
- Global Maternal and Child Health
- Gallbladder and Bile Duct Disorders
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Chemotherapy-induced cardiotoxicity and mitigation
- Health Promotion and Cardiovascular Prevention
The University of Texas Health Science Center at San Antonio
2025
The University of Texas Health Science Center at Houston
2025
Rosalind Franklin University of Medicine and Science
2023-2024
Ross University School of Medicine
2023-2024
Mount Sinai Hospital
2018-2024
The Ohio State University
2023-2024
The Ohio State University Wexner Medical Center
2023-2024
University of Oklahoma Health Sciences Center
2024
University of Aruba
2024
King Edward Medical University
2021-2023
Nordic countries’ data offer a unique possibility to evaluate the long-term benefit of cervical cancer screening in context increasing risk human papillomavirus infection. Ad hoc-refined age-period-cohort models were applied last 50-year incidence from Denmark, Finland, Norway and Sweden project expected cases no-screening scenario. In absence screening, projected rates for 2006–2010 countries would have been between 3 5 times higher than observed rates. Over 60 000 or 41 49% may prevented...
PURPOSE To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor–positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455 ). METHODS Post-/pre-/perimenopausal women, or men, age 18 years older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly...
The United Arab Emirates is committed to integrating technology into higher education. In this study the researchers aim explore perspectives of university students on online assessments. An understanding students' views can help identify obstacles and promotors in embracing assessments at undergraduate level. social constructivist epistemology has been used qualitative understand preferences, apprehensions acceptance Semi-structured focus group discussions were carried out after recruiting...
<h2>Summary</h2><h3>Background</h3> Closure of an abdominal stoma, a common elective operation, is associated with frequent complications; one the commonest and impactful incisional hernia formation. We aimed to investigate whether biological mesh (collagen tissue matrix) can safely reduce incidence hernias at stoma closure site. <h3>Methods</h3> In this randomised controlled trial (ROCSS) done in 37 hospitals across three European countries (35 UK, Denmark, Netherlands), patients aged 18...
Owing to COVID-19 the Ministry of Education in United Arab Emirates mandated educational institutions shift remote learning. In this study perspectives on learning, both students and faculty, from Science major, a public university Dubai have been explored. A qualitative research was conducted through focus group discussions using semi-structured interview guide. All were recorded transcribed verbatim. Thematic content analysis carried out following coding analyzing NVivo 12. Recurrent,...
Background Bispecific T-cell engagers (BTEs) are novel agents used to treat hematological malignancies. Early trials were underpowered define cardiovascular adverse events (CVAE) and no large-scale studies systematically examined the CVAEs associated with BTEs. Methods Leveraging US Food Drug Administration’s Adverse Event Reporting System-(FAERS), we identified relative frequency of after initiation five BTE products approved by Administration between 2014 2023 for treatment Adjusted...
<h3>Importance</h3> Patients with breast cancer remain at risk of relapse after adjuvant therapy. Celecoxib has shown antitumor effects in preclinical models human cancer, but clinical evidence is lacking. <h3>Objective</h3> To evaluate the role celecoxib as an addition to conventional therapy for women ERBB2 (formerly HER2)–negative primary cancer. <h3>Design, Setting, and Participants</h3> The Randomized European Trial (REACT) was a phase 3, randomized, double-blind study conducted 160...
Cervical cancer (CC) is the seventh leading cause of death among women in United Arab Emirates (UAE), with most deaths attributed to late detection this cancer. The UAE lacks a national CC screening programme. Thus, cervical only performed opportunistically during women's visits health facilities. rates are as low 16.9 %, and little known about perspectives nation's educated Muslim regarding screening. Consequently, aim study explore towards Dubai promote strategies for increasing its...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy, with 5-year survival rate of 12%. The dense extracellular matrix (ECM) and cancer-associated fibroblast (CAF)-driven microenvironment contribute to tumor progression resistance current therapies, necessitating the development novel treatments. This study introduces CIDD-8633, selective small-molecule inhibitor targeting Discoidin Domain Receptor (DDR) complex, which plays crucial role in ECM-mediated signaling...
Abstract Background The treatment landscape for advanced non-small cell lung cancer (aNSCLC) has evolved rapidly since immuno-oncology (IO) therapies were introduced. This study used recent data to assess real-world patterns and clinical outcomes in aNSCLC the United Kingdom. Methods Electronic prescribing records of treatment-naive patients starting first-line (1 L) between June 2016 March 2018 (follow-up until December 2018) Kingdom assessed retrospectively. Patient characteristics...
The ability to deliver the planned dose and intensity of chemotherapy (the amount drug administered/unit time) is important for tumour control survival. In clinical practice, neutropenic events are main limiting factors towards achieving this aim. We assessed impact [defined as either hospital admission due febrile neutropenia (FN), delay ≥7 days or reduction ≥15% neutropenia] on (DI) in a random sample 50 patients with various solid tumours. Fifty who received systemic tumours were part...
Cardiovascular disease was the leading cause of death among women in United Arab Emirates (UAE) 2010. Heart attacks usually happen older thus symptoms heart may be masked by chronic diseases, which could explain delay seeking health care and higher mortality following an ischaemic episode women. This study seeks to a) highlight awareness diseases Emirati b) understand women's behaviour UAE. A cross sectional, descriptive conducted using a survey instrument adapted from American Association...
Cervical cancer has a high mortality rate worldwide; in Pakistan it kills more than 7000 women every year. Prevention is possible through vaccination against human papilloma virus, the causative agent of cervical cancer, or by screening for premalignant lesions routine Pap smear tests. We have studied knowledge and practices regarding its risk factors, prevention role virus testing, among young Karachi.Information was gathered using modified version Cancer Awareness Measure Toolkit 2.1 from...
Immune checkpoint inhibition (ICI)-based approaches have transformed the treatment landscape of numerous solid tumors. Glioblastoma (GBM) is an aggressive and almost universally fatal disease which in need novel options, combinations immune inhibitors, including dual agent therapy, are starting to be explored refractory GBM. Growing adoption ICI-based tumors has been met with improved understanding immune-related adverse events (IRAEs), primary hematologic events. Although management...
The CDK4/6 inhibitors significantly increase progression-free survival (PFS) in ER+/HER2- advanced breast cancer patients. In clinical trials, overall (OS) improvement has been demonstrated for ribociclib and abemaciclib but not palbociclib. We undertook a real-world evaluation of PFS OS 227 post-menopausal patients who received first-line inhibitors. There is no significant difference median (27.5 months vs. 25.7 months, p = 0.3) or (49.5 50.2 0.67) either palbociclib ribociclib,...
Abstract Contemporary anticancer therapies frequently have different efficacy and side effects in men women. Yet, whether women are well‐represented pivotal trials supporting contemporary drugs is unknown. Leveraging the Drugs@FDA database, clinicaltrials.gov , MEDLINE, publicly available FDA‐drug‐reviews, we identified all (phase II III) non‐sex specific FDA‐approval of (1998–2018). Observed‐enrollment‐rates were compared to expected‐population‐rates derived from concurrent...
Abstract Background Cancer is the third leading cause of death in United Arab Emirates (UAE); brain cancer ranks 10th among cancers, with 2.9% primary cancers originating from nervous system. The epidemiology has not been explored. unique population dynamics UAE make it a fertile ground for analyzing cancer. In this study, we aim to look at frequency patterns and distribution malignant tumors UAE. Methods A cross sectional study was carried out using data obtained Tawam Hospital Registry...
Burns affect millions every year and a model to mimic the pathophysiology of such injuries in detail is required better understand regeneration. The current gold standard for studying burn wounds are animal models, which under criticism due ethical considerations limited predictiveness. Here, we present three-dimensional model, based on an open-source monitor wound healing epidermal level. Skin equivalents were burned, using preheated metal cylinder. process was monitored regarding...
Abstract The thick smog that blanketed India's capital, New Delhi, in early November 2017 saw air quality index values peak above 1000 – a figure excess of three times the threshold value for ‘hazardous’ conditions. A public health emergency was declared. Delhi's result an existing ambient urban air‐pollution problem, significantly worsened by smoke blowing from numerous agricultural fires burning across neighbouring Punjab and Haryana states. Post‐summer monsoon regional air‐flow patterns,...
Abstract Background Day‐case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis day‐case rates, defined as day their operation, may be improved by better assessment using standard preoperative variables. Methods Data were extracted from a prospectively collected data set 166 UK Irish hospitals (CholeS). Cholecystectomies performed elective procedures divided into main (75%)...
Community-engaged research (CEnR) is a potent tool for addressing health inequities and fostering equitable relationships among communities, researchers, institutions. CEnR involves collaboration throughout the process, demonstrating improvements in study recruitment retention, intervention efficacy, program sustainability, capacity building partners, enhanced cultural relevance. Despite increasing demand CEnR, institutional policies, particularly human participation protection training...
Abstract Purpose Sleep quality commonly deteriorates in people receiving chemotherapy for breast cancer (BC). We aimed to determine feasibility and acceptability of telehealth-delivered cognitive behaviour therapy insomnia (CBT-I) with early BC (neo)adjuvant chemotherapy. Methods Multi-centre, single arm, phase 2 trial. People stage I-III received 4 sessions telehealth CBT-I over 8 weeks, during Participants completed Pittsburgh Quality Index (PSQI) other Patient Reported Outcome Measures...