A5102721084- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Digital Radiography and Breast Imaging
- Clinical practice guidelines implementation
- Economic and Financial Impacts of Cancer
- Public Health Policies and Education
- South Asian Studies and Diaspora
- South Asian Studies and Conflicts
- Primary Care and Health Outcomes
- Cancer Risks and Factors
- Child and Adolescent Health
- Advances in Oncology and Radiotherapy
- Metabolism and Genetic Disorders
- Politics and Conflicts in Afghanistan, Pakistan, and Middle East
- AI in cancer detection
- Ethics in Clinical Research
- Nursing Roles and Practices
- Nutrition, Genetics, and Disease
- Risk Perception and Management
- Radiology practices and education
- Global Health Workforce Issues
- Nursing Education, Practice, and Leadership
- Reformation and Early Modern Christianity
University of Illinois Chicago
2024
University Hospital Limerick
2018-2024
University of Limerick
2018-2022
Equal Hope
2011-2021
Foundation Medicine (United States)
2019
The Swiss Private Equity & Corporate Finance Association
2019
Royal College of Physicians of Ireland
2019
Ashland (United States)
2017-2018
Rush University Medical Center
2017
University of Cincinnati Medical Center
2014
Assess progress made to reduce racial disparity in breast cancer mortality Chicago compared nine other cities with largest African American populations and the US. The Non-Hispanic Black (NHB) White (NHW) female rates rate ratios (RR) (disparity) were between 1999 2005 2006 2013. Between two periods, NHB decreased by 13.9% (95% CI [−13.81, −13.92] 7.7% [−7.52, −7.83]) for NHW. A drop of 20% was observed, from 51% (RR: 1.51, 95% 41% 1.41, [1.30, 1.52]). Whereas Chicago's above that U.S.,...
A high-quality screening mammography program should find breast cancer when it exists and the lesion is small ensure that suspicious findings receive prompt follow-up. The Mammography Quality Standards Act (MQSA) guidelines related to tracking outcomes are insufficient for assessing quality of care. We used data from a improvement project determine whether facilities could show they met certain benchmarks beyond those required by MQSA.Participating provided aggregate on examinations...
Assess geographic variation in breast cancer racial mortality disparity by age cohorts US and ten cities with large African American populations.Non-Hispanic Black (NHB) Non-Hispanic White (NHW) female rates NHB:NHW rate ratio (RR) (disparity) were calculated four group categories: <40, 40-49, 50-64 65+ time period 1999-2013.In all 10 the US, most pronounced disparities, measured RR, seen among younger women. In RR ranges from 1.71 Houston to 5.37 Washington, DC. For 50-64, was less...
ABSTRACT To investigate the molecular mechanisms responsible for temporal and spatial control of cell movements during development, we have been studying migration a small group follicle cells, called border in Drosophila ovary. Timely initiation requires product slow cells (slbo) locus, which encodes homolog transcription factor C/EBP. Here report evidence that one target C/EBP is FGF receptor encoded by breathless (btl) locus. btl expression ovary was cell-specific, beginning just prior to...
Exercise is a critical component in the management of pediatric obesity. Currently, continuous aerobic exercise (AE) standard care for weight programs. The 2008 Physical Activity Guidelines Americans primarily promote activity children, and aerobic-based at steady intensity typically prescribed programs1. Several studies adults, however, show advantages high-intensity interval (HIIE) over A Eat improving fitness health both healthy obese people2–4. These benefits HIIE compared to AE have...
OBJECTIVE. One central question pertaining to mammography quality relates discerning the optimal recall rate maximize cancer detection while minimizing unnecessary downstream diagnostic imaging and breast biopsies. We examined trade-offs for higher rates in terms of biopsy recommendations a single large health care organization. MATERIALS AND METHODS. included 2D analog, digital, 3D digital (tomosynthesis) screening examinations among women 40-79 years old performed between January 1, 2005,...
Abstract Background: In a racially and ethnically diverse sample of recently diagnosed urban patients with breast cancer, we examined associations patient, tumor biology, mammography facility characteristics on the probability symptomatic discovery their cancer despite recent prior screening mammogram. Methods: Breast Cancer Care in Chicago study, self-reports at interview were used to define as having screen-detected or awareness mammogram (SADRS), past 1 2 years. Patients who did not...
A diverse set of contractile protein genes and alternatively spliced isoforms is expressed during the process cardiac maturation. large variety functional sarcomeric units may occur at various stages development, in different regions heart pathologic states. In this review, developmental program individual gene families discussed with an emphasis on effects maturational changes, particularly human myocardium.
ABSTRACT The purpose of this study was to determine the degree agreement between nursing home staff and families in assessing needs cognitively impaired residents. A convenience sample 36 family members residents with cognitive impairment nurses assigned those patients recruited from three homes. Nurse Resident Perceptions Questionnaire, adapted Lindgren Linton (1991), used assess functioning activities daily living, physiologic, psychosocial areas. Significant differences were found for...
Abstract Helicobacter pylori infection results in peptic ulceration and chronic gastritis through mechanisms which are not fully elucidated. Live H. activate the pro‐inflammatory transcription factor NF‐κB gastric epithelial cells. Patients may have ulcer disease absence of infection; therefore other factors contribute to inflammatory process. Maximal acid output patients with duodenal is significantly increased indicating a role for pathogenesis mucosal ulceration. The effect low pH on...
Many children with chronic genetic diseases are followed by specialty clinics that provide information as part of the care. Health services restrictions in Republic Ireland (ROI) can make wait for an appointment a counsellor long. We examined whether was being adequately understood when presented medical, but non-genetics staff to long term patients, using our national metabolic service example. The aim inform health professionals about need or role specialist setting. A questionnaire used...
Abstract Few researchers have used social cognitive theory and environment-based constructs to predict physical activity (PA) fitness in underserved middle-school children. Hence, we evaluated variables perceptions of the school environment PA middle children (N = 506, ages 10-14 years). Using multiple regression analyses accounted for 12% variance 13-21% fitness. The best predictors were barrier self-efficacy, classmate support, gender; whereas, only gender predicted results affirmed...
Community-engaged research (CEnR) is a potent tool for addressing health inequities and fostering equitable relationships among communities, researchers, institutions. CEnR involves collaboration throughout the process, demonstrating improvements in study recruitment retention, intervention efficacy, program sustainability, capacity building partners, enhanced cultural relevance. Despite increasing demand CEnR, institutional policies, particularly human participation protection training...
This randomized double blind AB/BA cross‐over trial evaluates the effect of oral modafinil versus placebo on spasticity, function, and quality life in children with cerebral palsy (CP). Outcomes were measured at start end both 8‐week treatment periods (modafinil placebo). The order was randomly assigned. There a 4‐week wash‐out period between treatments. Primary outcomes include Modified Ashworth Score (MAS), Caregiver Priorities Child Health Index Life Disabilities (CPCHILD),...
Hypertension is a key risk factor for stroke, cardiovascular disease and dementia. Although the link between weight, sodium hypertension established in younger people, little known about their inter-relationship people beyond 80 years of age. Associations blood pressure, anthropometric indices were investigated 495 apparently healthy, community-living participants (age 90, SD 4.8; range 80–106), from cross-sectional Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST) study. In...
Introduction As the COVID-19 pandemic placed a spotlight on health inequities in United States, this study aimed to determine local programmatic needs of community organizations (CO) delivering interventions across Chicago. Methods In summer 2021, Chicagoland CEAL Program interviewed 34 COs that were providing education, testing, and/or vaccinations communities experiencing poor outcomes. The interviews analyzed thematically and organized around logistical challenges funding/resource needs....
Cross-linking of LFA-1 induces an active locomotory phenotype in T cells. In this study we demonstrate that cross-linking using a monoclonal antibody results the secretion MIP-1α and MIP-1β. Similar were seen with anti-CD44 but not anti-transferrin receptor or anti-MHC class 1. We examined ability activated lymphocytes to migrate onto substrate consisting large protein G-Sepharose beads coated anti-LFA-1 anti-CD44. system signal is provided by cells at point contact beads. Cells migrated...
Bradyrhizobium japonicum, a symbiotic nitrogen-fixing bacterium, has complex respiratory electron-transport chain, capable of functioning throughout wide range oxygen tensions. It does so by synthesizing number terminal oxidases, each appropriate for different environmental conditions. Several genes encoding oxidases from B. japonicum have been cloned, but it is unknown what roles these individual play. In this paper, we describe the cloning and sequencing coxX gene large catalytic subunit...