A5033148873- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Microbial Metabolism and Applications
- Nanoplatforms for cancer theranostics
- melanin and skin pigmentation
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- Bioactive natural compounds
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Advanced Breast Cancer Therapies
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cardiac Structural Anomalies and Repair
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Hedgehog Signaling Pathway Studies
The University of Texas Health Science Center at Houston
2023-2025
The University of Texas Health Science Center at San Antonio
2023-2025
Children's Cancer Center
2025
Texas State University
2020-2023
Abstract Introduction: Medulloblastoma (MB) is the most common malignant brain tumor in children, responsible for 20% of all childhood tumor-related deaths. Standard treatment includes surgical resection followed by cranial spinal irradiation and chemotherapy. However, this approach causes severe toxicity, leading to long-term neurological neuropsychological disabilities, survival remains below 70%. Moreover, therapy-resistant cancer stem cells (CSCs) drive growth, relapse, progression....
Introduction: Medulloblastoma (MB) is pediatric brain cancer originate from the cerebellum, and accounts for large number of all childhood related deaths. MB grows vigorously, spreads to central nervous system (CNS) through cerebrospinal fluid, leading leptomeningeal metastases in 66% patients. are commonly treated with a combination surgery, radiation, chemotherapy drugs like vincristine. Unfortunately, at young age, radiation exposure treatment lead high toxicity which ultimately...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy, with 5-year survival rate of 12%. The dense extracellular matrix (ECM) and cancer-associated fibroblast (CAF)-driven microenvironment contribute to tumor progression resistance current therapies, necessitating the development novel treatments. This study introduces CIDD-8633, selective small-molecule inhibitor targeting Discoidin Domain Receptor (DDR) complex, which plays crucial role in ECM-mediated signaling...
Recent focus on cancer immunotherapies has led to significant interest in the development of therapeutic strategies that can lead immunogenic cell death (ICD), which cause activation an immune response against tumor cells and improve immunotherapy outcomes by enhancing immunogenicity microenvironment. In this work, a nanomedicine-mediated combination therapy is used deliver ICD inducers doxorubicin (Dox), chemotherapeutic agent, indocyanine green (ICG), photothermal agent. These agents are...
Abstract The Xiphophorus melanoma receptor kinase gene, xmrk , is a bona fide oncogene driving melanocyte tumorigenesis of fish. When ectopically expressed in medaka, it not only induces development several pigment cell tumor types different strains medaka but also within the same animal, suggesting its oncogenic activity has transcriptomic background effect. Although central pathways that utilizes to lead melanomagenesis are well documented, genes and genetic modulate effect alter course...
Abstract Introduction: Medulloblastoma (MB) is the most common malignant brain cancer in children. Although long-term survival has improved recent years, only a modest percentage of patients survive high-risk disease. The quality life for those who substantially reduced due to high toxicity associated with radiation and chemotherapy. Therefore, identification safe potent therapeutic approaches that can sensitize therapy response MB without inducing will lead more efficient treatment...
Abstract Introduction: Microtubule-associated proteins (MAPs) regulate microtubule dynamics, which is critical for controlling cell division, proliferation, migration, and intracellular transport. Due to their role in maintaining cellular integrity, microtubules have served as potent therapeutic targets cancer treatment. Here, we report “Matrin 3 (MATR3)” a novel MAP that interacts with β- tubulin γ-tubulin, constitutes organizing center (MTOC) essential proper spindle formation chromosomal...
Abstract Background: Medulloblastoma (MB) is the most common malignant brain cancer in children. Despite progress made treating MB, 5-year survival rate for high-risk tumors remains poor and risk of recurrence within 2 years treatment still high. Unfortunately, patients who do survive have reduced quality life because highly toxic side effects radiation chemotherapy. Those facts underline importance identifying new drivers MB understanding mechanism by which those may promote MB. Using...
Abstract Introduction: The development of novel targeted therapies is urgently required for improving the outcome triple negative breast cancer (TNBC) patients. Chemotherapy common treatment option TNBC. However, resistance and tumor relapse remain major obstacles hindering effectiveness chemotherapeutic agents in Therefore, identifying genes/factors that sensitize cells to could improve Here we report Signal peptide CUB domain EGF-like 3 (SCUBE3) genes as a therapeutic adjuvant can efficacy...
Abstract Introduction: Medulloblastoma (MB) is the most common malignant childhood brain tumor. It accounts for 20% of all cancer deaths. MB are very fast-growing tumors, which spreads to central nervous system through cerebrospinal fluid, leading leptomeningeal metastases that occurs up 66% in patients. Despite progress treating MB, 5-year survival rate high-risk remains poor with high recurrence. Moreover, quality life those kids who do survive substantially reduced due toxicity associated...
Abstract Background: Medulloblastoma (MB) is the most common malignant brain cancer in children. Despite progress made treating MB, 5-year survival rate for high-risk tumors remains poor and risk of recurrence within 2 years treatment still high. Almost all MB deaths are attributed to leptomeningeal dissemination (LMD) as spreads exclusively through cerebrospinal fluid (CSF) spinal intracranial leptomeninges. Unfortunately, patients who do survive have reduced quality life because highly...
Abstract The Xiphophorus melanoma receptor kinase gene, xmrk , is a bona fide oncogene driving melanocyte tumorigenesis of fish. When ectopically expressed in medaka, it not only induces development several pigment cell tumor types different strains but also within the same animal, suggesting its oncogenic activity has transcriptomic background effect. Although central pathways that utilizes to lead melanomagenesis are well documented, genes and genetic modulate effect, alter course disease...