A5040489938- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Immunotherapy and Immune Responses
- Photochromic and Fluorescence Chemistry
- Photodynamic Therapy Research Studies
- TiO2 Photocatalysis and Solar Cells
- Advanced Photocatalysis Techniques
- Carbohydrate Chemistry and Synthesis
- Cancer Immunotherapy and Biomarkers
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Gas Sensing Nanomaterials and Sensors
Texas State University
2018-2020
Ankara University
2010
Marine alkaloid rigidins are cytotoxic compounds known to kill cancer cells at nanomolar concentrations by targeting the microtubule network. Here, a rigidin analogue containing thioether group was "caged" coordination of its photosensitive ruthenium complex. In dark, coordinated fragment prevented from inhibiting tubulin polymerization and reduced toxicity in 2D cell line monolayers, 3D lung tumor spheroids (A549), xenograft (A549) nude mice. Photochemical activation prodrug upon green...
Despite significant progress in the field of oncology, cancer remains one leading causes death. Chemotherapy is most common treatment options for patients but well known to result off-target toxicity. Theranostic nanomedicines that integrate diagnostic and therapeutic functions within an all-in-one platform can increase tumor selectivity more effective chemotherapy aid diagnosis monitoring responses.In this work, theranostic nanoparticles were synthesized with commonly used biocompatible...
Tin oxide nanoparticles about 4 nm in size were successfully synthesized using hydrothermal method. The photocatalytic activity of the particles was determined by decolorization malachite green (MG) and titanium yellow (TY) under UV light. 12 ppm MG TY used for solution with an initial volume 100 mL. amounts catalysts 10, 30 50 mg. effect catalyst loading on reaction kinetic parameters rate constants (k) determined. In order to reveal efficiency nano particles, further experiments conducted...
Our laboratories have been investigating synthetic analogues of marine alkaloid rigidins that possess promising anticancer activities. These analogues, based on the 7-deazahypoxanthine skeleton, are available in one- or two-step sequences and exert cytotoxicity by disrupting microtubule dynamics cancer cells. In present work we extended structure-activity relationship (SAR) data to N3- N9-substituted derivatives. Although N3 substitution results loss activity, compounds retain nanomolar...